Stroke survivors: could this seated exercise boost your fitness and brain health?
NCT ID NCT05936008
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how different types of exercise (interval vs. continuous) and intensity levels (moderate vs. high) affect aerobic fitness and blood vessel health in people who have had a stroke. 59 participants used a seated stepper that moves both arms and legs. The goal was to find the best exercise prescription to improve fitness and brain blood flow after a stroke.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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59 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Both sexes between the age of 20-85 years at time of consent * Chronic ischemic or hemorrhagic stroke 6 months to 15 years at consent. People with stroke and newly diagnosed cardiovascular complications had \>50% prevalence of recurrent stroke at 5 years. Index stroke or recurrent stroke on same side as index stroke will be allowed. * Ability to walk over ground with assistive devices and no continuous physical assistance from another person to perform tests for gait speed and six-minute walk test * Exercise continuously for minimum of 30 watts for 3 minutes on the recumbent stepper to demonstrate ability to perform the exercise test. * No aerobic exercise contraindications or other safety/physical concerns during the submaximal exercise test. * Able to communicate with investigators, follow 2-step command \& correctly answer consent comprehension questions * Currently participating in less than 150 minutes of physical activity/week assessed by the Rapid Assessment of Physical Activity * Stable blood pressure \& statin medication doses for 30 days prior to enrollment due to effects on vascular health/hemodynamics Exclusion Criteria: * Hospitalization for cardiac or pulmonary disease within past 3 months * Implanted pacemaker or defibrillator limiting exercise performance * Reported pain that limits or interferes with activities of daily living and physical activity/exercise * Severe LE spasticity (Ashworth \>2) due to inability to exercise * Recent history (\<3 months) of illicit drug or alcohol abuse or diagnosis of significant mental illness * Major post-stroke depression (Patient Health Questionnaire, PHQ-9 ≥ 1084) * Currently participating in physical therapy targeting lower extremity function or another interventional study that may influence study outcomes * Other significant neurologic, orthopedic or peripheral vascular conditions that would limit exercise participation * Oxygen-dependent chronic obstructive pulmonary disease * Diagnosis of other neurological disease (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease) * Self report pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Moving patterns may help stroke survivors read faster
- Vibrating wearables put stroke walking to the test
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- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next