Brain blood flow differs between sexes – new study explores why
NCT ID NCT04265053
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 35 times
Summary
This completed early-phase study looked at how sex and stress influence blood flow in the brain. Researchers gave 42 healthy young adults indomethacin (an anti-inflammatory drug) or a placebo to test whether a specific mechanism (COX signaling) explains differences between men and women. The goal is to gather knowledge that could lead to better, sex-specific treatments for brain blood vessel diseases.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Wisconsin, Madison
Madison, Wisconsin, 53706, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Indomethacin
What this could lead to
If successful, this could point toward sex-specific therapies for cerebrovascular diseases like stroke.
What could go wrong
This is a very early, small study in healthy young adults, so findings may not apply to older or sick populations. The drug used (indomethacin) is not being tested as a treatment here.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.