Cerebrovascular disorder

Newborns who suffer a stroke or oxygen loss around birth can develop cerebral palsy and other lifelong disabilities, and no treatment can repair the damage. Researchers at UMC Utrecht are testing whether a single dose of bone marrow-derived mesenchymal stromal cells, sprayed into…

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

Researchers are comparing a drug-coated balloon procedure plus intensive medical care against intensive medical care alone in people with severely narrowed brain arteries that have caused stroke or mini-stroke symptoms. The trial enrolls 570 adults aged 18 to 80. Everyone receive…

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

Researchers are testing whether adding a PCSK9 inhibitor to standard statin therapy can stabilize vulnerable plaques in the carotid artery, the main blood vessel to the brain. The trial enrolls 120 adults with carotid narrowing and high-risk plaque features. Participants receive …

Researchers compare two approaches for adults with small unruptured brain aneurysms found by chance: regular imaging surveillance without initial treatment, or immediate endovascular or surgical repair. The trial enrolls 600 adults aged 35 to 75 with aneurysms measuring 2 to 7.9 …

Researchers are testing whether adding tirofiban to standard antiplatelet therapy improves recovery for people whose ruptured brain aneurysm is repaired with a stent. The trial enrolls adults with acute subarachnoid hemorrhage who receive stent-assisted coiling within 72 hours of…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

Researchers are testing an experimental treatment called AB126, made from neural exosomes, in adults who have had a moderate to severe acute ischemic stroke and who showed limited improvement after a procedure to clear the blocked blood vessel. The trial aims to find out whether …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

This study tests whether combining non-invasive light therapy on the head, electrical stimulation cycling for the arms, and cognitive tasks can improve thinking and arm movement in adults who have had a stroke. Participants attend 10 sessions over 2 weeks, and researchers measure…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This trial tests whether a procedure to reopen a blocked carotid artery in the neck can improve cognitive function in people who have had a stroke or mini-stroke and now have thinking or memory problems. Participants are randomly assigned to receive standard medical care alone, o…

This trial tests whether a granule form of the Chinese herbal formula Huayu Jiedu (FTFY-919) works as well as the traditional decoction for people with acute hypertensive intracerebral hemorrhage, a type of stroke caused by bleeding in the brain. About 300 adults who have had a b…

This trial tests whether treadmill training with a robotic cable that gently pulls walkers side-to-side can improve balance and daily walking in adults who had a stroke. Participants complete 20 high-intensity treadmill sessions, either with the robotic pulling forces or without …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This pilot study tests whether stroke survivors can follow a self-managed exercise program at home to maintain their health. Participants first complete an 18-session guided program with respiratory, strengthening, and cardiovascular exercises, plus weekly virtual coaching sessio…

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This study tests a brain-computer interface called BrainGate2 in people with expressive aphasia, a condition where stroke damage makes it hard to speak. Researchers place small sensors in the brain areas that control speech, then record brain activity while participants try to sp…

This study tests a new non-invasive brain stimulation method that targets deep brain structures through the scalp, without surgery, to improve arm and hand function in people who had a stroke at least 12 weeks ago. Participants receive either active stimulation or a sham version,…

This trial tests whether a procedure to remove blood clots from the brain, called endovascular treatment, can improve recovery in people who have had a severe stroke with a very large area of brain damage. Participants receive either the clot-removal procedure plus standard medic…

This trial tests whether a rapid combination of minimally invasive surgery, intensive blood pressure lowering, and a clot-stabilizing drug can improve recovery after a bleeding stroke. Adults with a moderate to large bleed in the brain are randomly assigned to receive this early …

This trial tests whether a home-based electrical stimulation device can help people recovering from stroke improve their walking. Participants will use the device on leg muscles for 30 minutes, five times a week, for 12 weeks, with remote support via a smartphone app. The study c…

This study looks at whether a clot-busting drug called prourokinase can improve recovery in people who have an acute ischemic stroke, when given within 4.5 hours of symptoms starting. About 3,000 adults will receive the drug intravenously and be followed for 90 days to see how we…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This trial tests whether adding a traditional Chinese medicine, Angong Niuhuang Pill, to standard stroke care can improve outcomes for adults who have just had a stroke. The study uses an adaptive platform design, allowing multiple treatments to be tested simultaneously and effic…

This trial tests whether a brain-computer interface called Lifescapes can help stroke survivors with severe hand paralysis improve arm and hand function. The system reads brain signals during imagined movements and pairs them with electrical stimulation and robotic assistance to …

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This pilot trial tests whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve arm movement in people who had a stroke at least nine months ago. Participants receive either real or sham stimulation three times a we…

This trial tests whether a drug called recombinant human prourokinase (rhPro-UK) can improve recovery in people who have had a stroke caused by a blocked medium-sized blood vessel in the brain, when given 4.5 to 24 hours after symptoms begin. Participants are selected using brain…

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This study tests whether huperzine A, an injected drug, can help prevent or reduce memory and thinking problems that often follow surgery for a bleeding brain aneurysm. Adults aged 18-70 who had an aneurysm bleed and underwent endovascular or surgical treatment will receive eithe…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests whether adding lumbrokinase, an enzyme derived from earthworms, to standard aspirin treatment can improve recovery in people who have had a moderate-to-severe ischemic stroke. Participants receive either lumbrokinase capsules or a placebo, along with aspirin, for…

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This study tests whether giving the seizure medicine levetiracetam right after a brain bleed (intracerebral hemorrhage) can prevent seizures and improve long-term recovery. About 580 adults will receive either the drug or a placebo for up to 7 days, and their level of disability …

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stro…

This trial compares three different embolic materials—particles, liquid embolics, and coils—used during a procedure called middle meningeal artery embolization to treat chronic subdural hematoma, a type of bleeding on the brain's surface. The study will enroll 30 adults undergoin…

This study tests whether motor cortex stimulation – a device that sends mild electrical pulses to the brain's movement area – can reduce chronic pain after a stroke that affects the thalamus. Participants who do not get relief from standard pain treatments will have electrodes te…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This phase II trial is testing whether an experimental drug called LT3001 can help people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will include about 300 participants who receive either a high or low dose of …

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This trial is testing whether an experimental drug called HRS-4029 can improve outcomes for people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will compare the drug against a placebo in about 340 participants wh…

This study tests a device that uses sound waves (lithotripsy) to break up calcium buildup in the carotid arteries—the main arteries in the neck—before placing a stent to keep them open. The goal is to see if this approach reduces complications like stroke, heart attack, or death …

This study tests whether a supervised group exercise program, called EINTER, can improve muscle strength and walking ability in adults recovering from stroke. The program combines cycling and strength training, tailored to each person, and runs for up to four weeks. Researchers w…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial investigates whether a specific type of breathing exercise — functional inspiratory muscle training — can improve walking patterns in people who had a stroke more than six months ago. Sixty participants will be randomly assigned to either this new training or conventio…

This trial tests whether adding either high-repetition task-oriented training or high-intensity gait training to standard neurodevelopmental therapy helps people with chronic stroke walk farther and move more easily. Forty-five participants who had a stroke at least six months ag…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This trial tests whether giving high-concentration oxygen during a clot-removal procedure can improve recovery for people having a major stroke who arrive at the hospital 6 to 24 hours after symptoms began. Participants are randomly assigned to receive either the oxygen therapy o…

This study compares two innovative therapies—immersive virtual reality and proprioceptive neuromuscular facilitation (PNF)—against standard physical therapy for improving quality of life in people who had a stroke at least six months ago. Participants will complete 12 sessions ov…

This study looks at whether a minimally invasive surgical procedure can help people with a spontaneous deep brain hemorrhage (bleeding in the basal ganglia) recover better than standard medical treatment alone. Researchers will follow 300 adults for 180 days, measuring survival, …

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study will follow 5,000 adults with carotid artery disease who receive a treatment called TCAR using the ENROUTE system. The goal is to see how safe and effective the device is in real-world settings, especially for groups not well-studied before. Researchers will track majo…

This pilot study tests whether a program called GRIP—which combines a soft robotic glove with a virtual reality system—can help adults recovering from a recent stroke improve hand and arm function. About 20 participants in inpatient rehabilitation will be randomly assigned to rec…

This study tests whether a single injection of Recaticimab, a cholesterol-lowering drug, can help people recover better after a stroke caused by narrowed brain arteries. About 1,200 participants will receive either the drug or a placebo, plus standard care. The main goal is to se…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study investigates whether a standardized microsurgical procedure can safely and effectively remove large spontaneous brain hemorrhages (bleeds) located near the brain's surface. The procedure uses a microscope and computer guidance to evacuate the clot, with the goal of lea…

This trial tests whether a wearable hand robot, used at home with remote therapist support, is a feasible way to deliver intensive hand therapy to people who had a stroke at least six months ago. Participants will either use the robot for 12 weeks or receive the same amount of st…

This study tests whether a set of simple treatments—daily blood pressure checks, dietitian visits, hearing and vision tests, and mood screening—can help preserve thinking and memory after a stroke. About 50 adults who recently had a mild stroke will either receive this care bundl…

This trial compares a procedure to reopen blocked brain arteries (using balloons and stents) against standard medical therapy in people with chronic blockages. The goal is to see if the procedure reduces the risk of stroke or death within a year. Participants have had symptoms fr…

This trial tests whether ciprofol, a newer anesthetic, can keep blood pressure more stable than the standard drug propofol in people having general anesthesia for endovascular thrombectomy after an ischemic stroke. Stable blood pressure during the procedure may improve outcomes. …

This trial investigates whether giving two drugs—remifentanil and dexmedetomidine—soon after a spontaneous brain hemorrhage can safely lower blood pressure and improve recovery. The study includes adults with a brain bleed who have high blood pressure and are treated within six h…

This study develops and tests a standardized oral care protocol for stroke patients who have a breathing tube (orotracheal intubation). The goal is to see if this special mouth care plan can lower the risk of ventilator-associated pneumonia compared to usual care. The trial inclu…

This trial investigates whether adding Getong Tongluo Capsule, a traditional Chinese herbal medicine, to standard stroke care improves recovery in people who recently had an ischemic stroke. Researchers will also explore if the capsule works by affecting gut bacteria and brain co…

This trial tests whether giving a clot-busting drug directly into the brain arteries after mechanical clot removal can improve recovery in people having a severe stroke. About 1,500 adults with acute ischemic stroke who undergo endovascular thrombectomy will be randomly assigned …

This study tests whether combining spinal cord stimulation with brain-computer interface training can improve arm function in people who had a stroke more than six months ago. Participants will either receive both treatments or the brain-computer training alone. The goal is to se…

This trial tests whether a sublingual (under-the-tongue) tablet of edaravone dexborneol, given within 6 hours of stroke onset during transfer between hospitals, can improve functional recovery in people with acute ischemic stroke. About 1,040 participants will receive either the …

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This study tests whether combining a gentle electrical brain stimulation (called FNS) with sling-based exercises can help people who have paralysis on one side after a stroke. The trial will enroll 54 adults aged 18-70 who had a stroke within the last 6 months. Participants will …

This trial tests whether using a balloon guide catheter along with a filter can better protect the brain during carotid artery stenting. People with narrowed neck arteries (carotid stenosis) who need stenting are randomly assigned to get either the balloon-plus-filter combo or a …

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This trial tests whether giving blood pressure medication inside a mobile stroke unit—a special ambulance with a CT scanner—can improve outcomes for people having a brain bleed. About 706 adults with high blood pressure and a recent stroke will be randomly assigned to either the …

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study tests whether a stellate ganglion block (a nerve block injection) can improve neurological outcomes in people who have had a bleeding stroke from a ruptured aneurysm. The procedure is done before surgery to reduce brain artery spasms and improve blood flow. Researchers…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This study tests whether adding 20 minutes of moderate-to-high intensity aerobic exercise before constraint-induced movement therapy helps stroke survivors walk better. Fifty adults who had a stroke at least 6 months ago will take part in a 4-week intensive program, followed by a…

This study tests whether people who have had a minor stroke or a high-risk mini-stroke can safely stop one of their two blood thinners earlier than usual. About 3,800 participants will have their blood tested to see how they respond to the drug clopidogrel. Those who are sensitiv…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study tests whether giving aspirin early after repairing a ruptured brain aneurysm helps patients recover better. About 388 adults who had a bleeding aneurysm will receive either aspirin or a placebo for 10–14 days. The goal is to see if aspirin reduces brain complications a…

This pilot study tests whether an active smartwatch that gives real-time feedback, combined with regular nurse coaching, can help people who had a minor stroke or TIA walk more each day. Fifty participants will be randomly assigned to either an active smartwatch or a passive one …

This early-stage trial tests whether stem cells from human umbilical cords are safe and might help people recover from a severe stroke. About 35 adults who had a stroke within the last 48 hours will receive either the stem cells or a placebo. The study will check for side effects…

This study tests a drug called pro-urokinase in people who have had a stroke in the back part of the brain (posterior circulation) and can be treated within 4.5 to 24 hours after symptoms start. About 586 participants will receive either the drug or a placebo, along with standard…

This study tests whether the clot-busting drug tenecteplase is safe and effective for people having a stroke who took a blood thinner (DOAC) within the last 48 hours. About 660 adults will receive either tenecteplase or a placebo within 4.5 hours of stroke symptoms. The goal is t…

This study looks at whether doing a balloon angioplasty or placing a stent right after removing a blood clot from the brain can help people who have a stroke caused by a hardened artery. About 420 adults will be in the study. The goal is to see if this extra step improves recover…

This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) can reduce brain swelling and improve recovery in people who have had a bleeding stroke. About 200 adults with a specific type of brain bleed will receive either standard care or the drug plus standar…

This study tests a new device, the SOFIA Flow 88 Aspiration Catheter, to treat acute ischemic stroke caused by a large blocked artery. About 200 adults with moderate to severe stroke will be enrolled. The goal is to safely restore blood flow to the brain using only this catheter,…

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at 2,000 people who had a stroke to see which blood-thinning medicine works best to stop another stroke. The drugs being compared are indobufen, aspirin, cilostazol, and clopidogrel, used alone or in pairs. Researchers will track strokes and bleeding problems for…

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This study tests whether a personalized weaning strategy can help adults with chronic heart, brain, or lung conditions leave ventilators earlier. The strategy tailors care based on the main reason a patient struggles to breathe on their own, such as heart or muscle problems. Rese…

This study tests two traditional Chinese medicines, Dengzhan Xixin and Dengzhan Shengmai, in 358 adults who recently had an ischemic stroke. The goal is to see if these treatments improve recovery and reduce disability at 3 months. Researchers will also study how the medicines wo…

This study tests whether adding alirocumab (a cholesterol-lowering injection) to standard statin therapy can reduce bleeding inside fatty plaques in the carotid artery. About 280 people with a recent mini-stroke or stroke due to a 50-69% blocked neck artery will receive either al…

This study tests a new device called the iNstroke 5F catheter to remove blood clots in people having an acute ischemic stroke. The goal is to see if it can safely restore blood flow to the brain within 24 hours of symptoms starting. About 45 adults with moderate to severe strokes…

This pilot study will test whether a virtual reality (VR) rehab program done at home can help people recover movement and thinking skills after a stroke or with Parkinson's disease. Sixty participants will either use a VR headset for daily exercises or receive standard rehab. The…

This study tests a traditional Chinese medicine mixture (red ginseng, notoginseng, and rhubarb) to help people recover from a hypertensive brain bleed without surgery. About 902 participants will receive either the herbal mix or a placebo for 28 days, alongside standard care. The…

This study looks at whether giving a low-dose aspirin just 2 hours after clot-busting treatment for stroke is better than waiting the standard 24 hours. About 210 adults aged 18-65 who had a stroke will be randomly assigned to get aspirin early or at the usual time. The goal is t…

This study tests whether using a balloon guide catheter during carotid artery stenting can prevent small particles from traveling to the brain and causing strokes. About 126 people with narrowed neck arteries will be randomly assigned to receive the balloon protection or standard…

This study tests whether a smartphone-supported care program can improve health outcomes for stroke patients who have trouble swallowing. The program includes diet monitoring, doctor communication, and education. Researchers will compare 600 patients who receive this enhanced sup…

This trial tests a new stent called SILANCE for people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes severe headaches, ringing in the ears, and vision problems. The stent is placed in a narrowed vein in the brain to impro…

This early-phase study tests whether a drug called Tenecteplase (TNK) is safe to inject directly into a brain bleed (intracerebral hemorrhage). Five adults aged 18-80 with large bleeds will receive a single dose during standard surgery. The goal is to see if TNK can dissolve the …

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study tests whether a virtual reality (VR) home exercise program can help stroke survivors improve arm and hand function. Forty-eight adults who had a stroke at least 3 months ago will either use a VR headset to practice daily activities at home or receive standard therapy. …

This study tests whether cooling the brain with cold saline during clot-removal surgery helps people recover from severe strokes. About 322 adults with large strokes will be randomly assigned to get standard care or standard care plus local brain cooling. The main goal is to see …

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This study tests whether removing blood clots from brain veins (endovascular thrombectomy) plus standard blood thinners works better than blood thinners alone for people with severe cerebral venous sinus thrombosis (CVST). The trial will include 440 adults at high risk of poor ou…

This study tests whether managing blood pressure based on the brain's collateral circulation (backup blood flow) after stroke treatment leads to better recovery. About 544 adults who had a stroke due to a large artery blockage and received endovascular therapy will be enrolled. P…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people with acute ischemic stroke when given 4.5 to 9 hours after symptoms start. It uses a special MRI pattern (DWI-FLAIR mismatch) to identify patients who might still benefit. About 564 adults …

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a stroke and also developed heart muscle injury. RIC involves using a blood pressure cuff on the arm to briefly restrict blood flow, which may trigger the body's ow…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study looks at stroke patients who have small clots remaining in smaller brain arteries after the main clot has been removed. Half will get an extra procedure to remove those leftover clots, while the other half will receive standard care without extra intervention. The goal…

This study tests whether a drug called edaravone dexborneol can help people who have a stroke while also having active cancer. The drug is given by IV twice a day for 10-14 days. Researchers will check if it improves recovery and is safe. About 144 adults aged 18-80 will take par…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This study tests a smartphone app called StrokeApp designed to support people after a stroke or mini-stroke. The app provides educational content, medication reminders, and tools to track health. Researchers will compare quality of life and other health measures between 500 patie…

This study tests whether canagliflozin, a diabetes drug, can reduce dangerous brain swelling and bleeding in people who have had a severe stroke and are receiving clot-removal therapy. About 150 adults will be randomly assigned to take the drug for 14 days or receive standard car…

This phase 2 study will test how the drug sildenafil (Revatio) is processed in the bodies of 24 full-term newborns who experienced oxygen deprivation at birth and are already receiving standard cooling therapy. The goal is to measure drug levels and prepare for a larger trial tha…

This study tests whether adding a drug called human urinary kallidinogenase to standard clot-busting therapy can improve recovery after a stroke. About 220 adults who have had a moderate stroke will be randomly assigned to receive the combination or standard care alone. The main …

This study tests a new approach for people with a serious type of brain bleed (lobar intracerebral hemorrhage). It combines a highly precise, computer-guided surgery to drain the blood with a clot-busting drug called tenecteplase. The goal is to see if this treatment helps more p…

This study tests a drug called tirofiban (Aggrastat) in 82 people who have had bleeding from a brain aneurysm. The drug is given through a vein to prevent blood clots that can cause delayed brain damage. The main goal is to find the safest dose, while also checking if it reduces …

This study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start wil…

This study will test a special coil called the Penumbra PC400 in 100 adults aged 18 to 80 who have a medium or large brain aneurysm (5 mm or bigger). The coil is placed inside the aneurysm to block blood flow and prevent rupture or rebleeding. Researchers will track how well the …

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery can help stroke patients who still have blocked blood flow after a standard clot removal procedure. About 344 adults with a major stroke will be randomly assigned to receive eit…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This study tests whether the drug anakinra can limit brain damage in people who have had a severe stroke and have already undergone a procedure to remove a blood clot. About 159 adults aged 18-80 will receive either standard care or anakinra at different doses. The main goal is t…

This study tests whether adding two common medicines—colchicine (an anti-inflammatory) and low-dose rivaroxaban (a blood thinner)—to standard care can prevent future heart attacks, strokes, or death in people who recently had a stroke. About 4,500 adults who had a stroke within t…

This study tests whether taking a daily low-dose aspirin can reduce the risk of major heart problems and strokes in people who have survived a brain bleed (intracerebral hemorrhage). About 5,676 adults will be randomly assigned to receive either aspirin or a placebo for up to thr…

This study tests a new device called the iNstroke catheter, designed to remove blood clots from the brain in people having an acute ischemic stroke. About 160 participants will undergo a procedure where the catheter is used to suction out the clot. The main goal is to see how oft…

This Phase 2 trial tests whether giving human albumin directly into the artery supplying the brain, right after a clot is removed, can improve recovery in people with severe stroke. About 306 participants will be randomly assigned to receive either standard clot removal alone or …

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This pilot study tests whether a rehabilitation program using virtual reality, treadmills, and other technology can help people recover mobility after a stroke. 62 participants will receive the tech-based program, and their progress will be compared to similar patients who had us…

This study tests whether adding the drug eptifibatide after standard clot-dissolving treatment can help people with acute ischemic stroke recover better. It includes 786 adults who arrive at the hospital 4.5 to 24 hours after stroke symptoms start. The goal is to see if this comb…

This study tests whether giving a clot-busting drug directly into the brain artery, plus possibly removing the clot with a device, helps people with medium-sized stroke clots. About 614 participants who cannot receive standard IV clot-busters will be randomly assigned to either t…

This study looks at how well certain drugs protect the brain after a mild to moderate stroke. Researchers will follow 600 adults who had a stroke within the last 48 hours and received edaravone or dexrazoxane. The goal is to see if these drugs help patients recover better and are…

This study tests whether adding the blood thinner tirofiban after standard stroke treatment helps people recover better from a severe type of stroke caused by a blocked large artery in the brain. About 564 adults in China will receive either tirofiban or usual care after their in…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests a new biodegradable device that closes a common heart hole (PFO) in people who have already had a stroke or mini-stroke. The device is placed through a tube in the leg and dissolves over time, leaving no permanent implant. The trial will check if it safely and ef…

This study tests a traditional Chinese medicine called Bovis Calculus Stativus (cultivated bezoar) in 220 adults who had a stroke and are now unconscious or barely responsive. Participants receive either the medicine or a placebo for 5 days, and are followed for 90 days. The goal…

This study tests whether tranexamic acid (TXA), a drug that helps stop bleeding, can improve recovery in 2000 severely injured children with brain or torso injuries. The goal is to see if TXA reduces bleeding and improves quality of life and thinking skills. The trial is for chil…

This study tests whether the drug cilostazol can prevent delayed brain injury in people who have had a bleeding stroke from a burst aneurysm. About 316 adults will receive either cilostazol or a placebo for 14 days. The goal is to see if the drug reduces the risk of delayed brain…

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stro…

This study tests whether combining minimally invasive surgery with a drug called deferoxamine helps people recover better after a brain hemorrhage. The surgery removes the blood clot, while the drug may protect brain cells. About 240 adults with moderate to severe bleeding will b…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This study tests a device called a flow diverter to treat brain aneurysms that are not balloon-shaped. The goal is to block blood flow into the aneurysm, helping it heal and preventing rupture. About 168 adults aged 18 to 80 will be enrolled, and the main outcome is complete bloc…

This study tests whether a Chinese herbal pill (Naoxuekang Dropping Pills) can lower the chance of having another stroke, heart attack, or blood clot in people who recently had a brain bleed from high blood pressure. About 1,950 adults will take either the pill or a placebo for 9…

This study tests a new surgical technique called Expansion-floating Craniotomy (EC) for people with life-threatening brain swelling after a massive stroke. The standard surgery removes a piece of skull to relieve pressure, but requires a second surgery months later to replace the…

This study tests whether adding the steroid methylprednisolone to standard clot-removal treatment helps people recover from severe stroke. About 912 adults aged 18–85 with a large clot in the front part of the brain will receive either the steroid or a placebo for three days. The…

This study tests whether adding a PCSK9 inhibitor (a cholesterol-lowering drug) to standard care helps people recover better after a stroke caused by a blocked artery. About 478 adults who had a stroke and received a procedure to reopen the blocked vessel will be randomly assigne…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard nimodipine treatment helps people recover better after a brain aneurysm rupture. Researchers will enroll 630 adults in France within 96 hours of the bleed and follow them for 6 months. The go…

This study tests whether the clot-busting drug tenecteplase can improve recovery in people who have a major stroke caused by a large blocked artery, but who cannot have a procedure to remove the clot. The trial includes 794 adults who arrive at the hospital 4.5 to 24 hours after …

This study tests a traditional Chinese herbal medicine called Xinglou Chengqi Granule for people who recently had a stroke. Researchers want to find the best dose and see if it helps improve recovery. Sixty adults aged 18-70 with moderate stroke symptoms will receive either a hig…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests whether raising or lowering blood pressure after aneurysm repair improves outcomes in people with a brain bleed. 750 adults who had surgery within 72 hours will be randomly assigned to different blood pressure targets. Their recovery will be tracked for 6 months …

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Carotid endarterectomy removes plaque from the neck artery, and surgeons clamp the artery briefly during the operation. In awake patients, doctors check hand strength and speech to decide if a shunt is needed. This study tests whether a forehead sensor that measures brain oxygen …

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study tests whether a high-powered 7T MRI can measure sodium levels in the brain tissue around a bleeding stroke, and whether a drop in sodium predicts worse swelling and disability. Researchers will also use an AI algorithm to create similar sodium maps from standard 3T MRI…

This study is testing a new device called PropArm-PosiMoF (PropArm) that aims to measure proprioception—your sense of where your arm is and how much force it uses—in the upper limbs. Researchers will first check how reliable and accurate the device is in healthy young adults, the…

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

This study tests a new type of ultrasound that can see through the skull to find tiny metal pieces left after brain aneurysm surgery. About 78 adults who had aneurysm clipping will get this ultrasound within 3 hours after surgery, along with a standard CT scan. The goal is to see…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study looks at whether a blood test can detect brain bleeding in older adults (75+) who fall repeatedly. Instead of always using a CT scan, which can be hard to get quickly, researchers will measure two proteins in the blood. The goal is to see if this test is accurate enoug…

This study tests a portable device that uses near-infrared light to find brain bleeds in people with traumatic brain injury. The goal is to see if it works as well as a CT scan, especially in places like battlefields or rural areas where CT machines aren't available. About 80 adu…

This study tests a rapid blood test (GFAP) that paramedics can use in ambulances to quickly identify if a stroke patient has a brain bleed. The test aims to help doctors decide the best treatment faster. About 465 adults with stroke symptoms will be enrolled within 3 hours of sym…

This study tests a new 3D ultrasound imaging method to map blood vessels in the heart and brain of people with atherosclerosis who are scheduled for carotid surgery. The goal is to see if this non-invasive, radiation-free technique can detect blockages and incomplete vessel netwo…

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

Researchers are testing a community-led prevention program called Qungasvik-Healthy Hearts in three rural Alaska Native communities. The program adapts traditional Yup'ik practices such as hunting, gathering, and fishing to see whether they can reduce risk factors for heart and c…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treat…

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This trial tests whether high-intensity cholesterol-lowering therapy prevents strokes and heart problems better than moderate therapy in adults with narrowing of brain arteries but no symptoms yet. Participants are randomly assigned to one of two treatment strengths and followed …

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether anticoagulant medications (like rivaroxaban or apixaban) are better than aspirin at preventing a second stroke in people who have had an ischemic stroke of unclear cause. Participants are adults who had a stroke within the past two weeks and show signs th…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study compares two ways of feeding patients with severe ischemic stroke who have trouble swallowing. The goal is to see if feeding through a tube placed past the stomach (post-pyloric) reduces the chance of developing pneumonia compared to standard stomach feeding. About 174…

This study tests whether a tablet called edaravone dexborneol can prevent epilepsy in people who have had a stroke and are at high risk. About 160 adults will receive either the tablet or a placebo for three months, starting within 48 hours of their stroke. Researchers will track…

This early study tests the safety of a 7-day intravenous drip of propranolol (a drug usually used for heart conditions) to prevent pneumonia in 30 adults who have had a severe brain bleed. The goal is to find the best dose and see if it reduces lung infections. Participants must …

This study tests whether kangaroo care (skin-to-skin contact with a parent) can reduce the risk of severe brain bleeding in extremely preterm newborns. About 314 babies born at 28 weeks or earlier will be randomly placed in a side-lying kangaroo position, a prone kangaroo positio…

This study tests whether adding a very low dose (15 mg) of the blood thinner edoxaban to standard aspirin or clopidogrel can prevent repeat strokes in people aged 75 and older who have already had an ischemic stroke. About 1,200 participants will be randomly assigned to receive e…

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

Researchers test whether optokinetic stimulation without a reading task improves reading speed in adults with hemianopic alexia after stroke. Participants receive 4 weeks of stimulation without a reading task and 4 weeks with a reading task, in random order. The study compares re…

Stroke survivors often walk more slowly and struggle to produce the movements needed for efficient walking. This study tests whether small wearable devices that vibrate during walking can help people with chronic stroke change specific walking movements linked to speed, propulsio…

Researchers are testing whether adding diaphragmatic breathing training to standard physiotherapy helps people with chronic stroke improve trunk control and postural stability. Forty adults who had a stroke at least six months earlier will be randomly assigned to either breathing…

Researchers are testing whether a rehabilitation program that combines mental tasks with balance exercises helps stroke survivors who have hemispatial neglect, a condition where the brain ignores one side of the body or space. Participants are randomly assigned to receive either …

Researchers test whether infusing lidocaine into the middle meningeal artery reduces headache severity in adults who have had a bleeding brain aneurysm. Participants receive either lidocaine or a saline placebo during their endovascular aneurysm repair. The trial measures headach…

This study looks at whether adding a non-invasive brain stimulation technique called rTMS to standard physical therapy can help people with chronic stroke-related weakness improve their movement, balance, and quality of life. Twenty adults who had a stroke at least six months ago…

After a stroke, many people need rehabilitation to regain movement, balance, and independence, but repetitive exercises can be hard to keep up. This small Swedish study tests a mixed-reality system called RehAtt XR, which uses special glasses to project digital holograms into the…

This study is testing whether a computer-based brain training program called RehaCom Online is acceptable and feasible for young stroke survivors (aged 18-65) who are working toward returning to work. Participants will use the program for at least 30 minutes, twice a week, for fi…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial is testing whether a bilingual (English and Urdu) mobile app can help stroke survivors improve movement in their affected arm and hand. The app guides users through structured exercises over eight weeks, starting with gentle range-of-motion activities and progressing t…

This trial tests whether a six-week personalized behavioral sleep program, called ISleepFAST, can improve sleep and daily functioning in adults who have had a stroke and still struggle with sleep or circadian problems. Forty participants will be randomly assigned to either the sl…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

Stroke survivors often face unmet needs long after the initial event, especially younger adults who must balance rehabilitation with work and family. This trial tests a 12-month digital education and peer support program, co-designed with patients and delivered through LINE commu…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial tests whether different types of pressure garments can improve touch sensation in the hand after a stroke. Adults aged 21 to 60 with hand stiffness will wear one of three garment designs for at least 12 hours daily over four weeks. Researchers will measure how the pres…

This study tests whether doing simple mental arithmetic before walking can improve gait speed and balance in people who have had a stroke. Seventeen participants will either solve math problems or watch a blank screen before walking. The goal is to see if this 'cognitive priming'…

This trial investigates whether adding radial shock wave therapy to standard botulinum toxin injections can further reduce ankle muscle stiffness and improve walking in people who have had a stroke. Participants receive either shock wave therapy plus physical therapy or physical …

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether special attention exercises can improve focus and quality of life in people who have had a stroke. 46 participants will do either attention training or standard rehab for 4 weeks. Researchers will measure changes in attention and daily functioning.

This study investigates whether sleeping on a gently rocking bed can improve sleep quality and memory in people undergoing neurorehabilitation after conditions like stroke, traumatic brain injury, or inflammatory diseases of the central nervous system. Participants will sleep on …

This study tests a special acupuncture technique called 'Nine Pharyngeal Acupoints' to help stroke patients who have trouble swallowing. The goal is to see if it improves their ability to eat and drink safely. Researchers will use muscle activity tests and video X-rays to measure…

This study tests a new type of physical therapy called NICE rehabilitation for people who have had a stroke and have weakness on one side. The therapy uses a computer to show patients how to activate specific muscles, helping them regain arm movement. Researchers will measure cha…

This study tests whether a quick, gentle push on the lower back (called lumbar spinal manipulation) can improve balance and lower fall risk in people who have had a chronic stroke. Fifty-two participants will receive both the real manipulation and a placebo version at different t…

This study tests whether eptinezumab, a drug used for migraines, can reduce the number of headache days in adults with idiopathic intracranial hypertension (IIH), a condition where high fluid pressure around the brain causes severe headaches. About 96 women aged 18-55 with chroni…

This study tests whether a non-invasive technique called transcranial focused ultrasound can help stroke survivors recover movement and thinking skills. Researchers will use brain scans and EEG to guide stimulation to specific areas. 60 adults who had a first stroke within the la…

This study looks at whether combining Frenkel exercises (repetitive movements to retrain the brain) with electrical muscle stimulation can improve balance, coordination, and body awareness in people who have had a stroke. About 38 adults aged 50-65 who can walk independently will…

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study tests if a non-invasive device that stimulates the vagus nerve can improve blood flow in the brain and thinking skills in people who had a stroke 6-12 months ago. Forty participants aged 50-60 with mild cognitive issues will receive the stimulation. Researchers will me…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This early study tests a robotic leg brace with smart software that senses how a person walks and adjusts its help in real time. Researchers want to see if this adaptive system improves walking speed and balance in stroke survivors compared to a standard brace. About 20 people, i…

This study looks at whether a gait training program delivered partly at home using a sensor and exercises is feasible and acceptable for people who have had a stroke. Twelve participants in Saudi Arabia will first train in a clinic, then continue at home for four weeks. The goal …

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This trial tests whether adding a structured home exercise program to regular clinic-based physical therapy helps people aged 40-50 with sub-acute stroke walk better and do daily activities. 72 participants will either get clinic rehab alone or clinic rehab plus home exercises li…

This study tests whether a virtual reality (VR) mindfulness program can help reduce anxiety in people who have had a stroke. About 48 adults who had a stroke more than 6 months ago and still feel anxious will use a VR headset for 9 sessions over 3 weeks. The goal is to see if thi…

This pilot study tests a new rehab program for people recovering from a stroke. The program combines walking exercises with mental tasks, like counting backwards or stepping over obstacles. Researchers want to see if it's safe, doable, and helps improve walking in real-world situ…

This pilot study tests whether individually tailored, non-invasive brain stimulation (high-definition tDCS) can improve arm function in 16 chronic stroke survivors when combined with rehabilitation therapy. Participants will receive either real or sham stimulation alongside modif…

This study looks at whether clenching your jaw can immediately improve walking and movement in people who had a stroke at least six months ago. Thirty participants will either clench their teeth on cotton rolls or keep their jaw relaxed, then take walking and balance tests. The g…

This study tests whether a gentle electrical current applied to the brain (tDCS) combined with hand exercises can improve hand function in people who had a stroke. Fifty-six participants will receive either real or sham tDCS for 20 sessions over four weeks. Researchers will use M…

This study tests a type of physical therapy called PNF (proprioceptive neuromuscular facilitation) for people who have had a stroke. The therapy uses specific leg exercises to improve balance, walking, and daily function. Sixty adults aged 40-80 who can walk with or without help …

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This study tests whether adding the drug dexmedetomidine during carotid artery surgery helps keep blood pressure more stable. About 44 adults having this surgery will be randomly assigned to receive either standard anesthesia alone or standard anesthesia plus dexmedetomidine. The…

This study tests whether a trained volunteer visiting a stroke survivor at home for 8 weeks can improve their ability to cope after hospital discharge. About 840 people who had a stroke and are returning home will either get this extra support or just their usual care. Researcher…

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether a personalized robotic telerehabilitation program can help people recover arm movement after a stroke. Seventy participants will use a wearable robotic device with virtual reality exercises at home for 4 weeks, supervised remotely. The goal is to see if t…

This study tests whether adding brain-computer interface (BCI) training to standard early rehabilitation helps people recover arm and leg movement after an acute ischemic stroke. Sixty adults aged 18 to 80 with one-sided limb weakness will receive either standard rehab alone or s…

This study tests a new robot-based therapy designed to improve arm movement and sensation in people who had a stroke more than six months ago. The therapy focuses on helping the brain better process sensory information from the arm. The trial will include 109 participants and com…

This study tests whether combining two types of non-invasive brain stimulation (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for one week. Researchers w…

This study compares standard hand-arm training with a version that also includes thinking tasks, like memory or attention exercises, for people recovering from a stroke. Twenty adults aged 40-70 with mild to moderate arm weakness will take part. The goal is to see if combining ph…

This study tests whether corrective exercises paired with rhythmic auditory stimulation (like music or beats) can improve balance, walking, and quality of life in people who have had a stroke. Thirty-two adults aged 40-60 with subacute ischemic stroke will participate. They will …

This study tests whether a gentle, non-invasive electrical brain stimulation (tACS) can improve working memory in people who have memory problems after a stroke. 24 participants will receive either real or fake stimulation for 40 minutes a day for 5 days, alongside cognitive ther…

This study tests a new, non-invasive brain stimulation technique called kTMP to help improve arm and hand function in people who have had a stroke. One hundred adults with chronic stroke-related arm weakness will receive either active or sham stimulation over 18 weeks. The goal i…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests whether a robotic arm exoskeleton, combined with standard physical therapy, can improve arm function in people who had a stroke at least six months ago. Sixty participants will do 15 sessions of robotic training plus 20 minutes of standard rehab. Researchers will…

This study will test a new type of rehabilitation robot that uses brain signals and mirror therapy to help stroke patients with arm weakness. The robot is non-invasive and designed to encourage the brain to re-learn movement. Researchers will enroll 40 adults aged 30 to 80 who ha…

This study looks at whether gentle foot massage (reflexology) can improve comfort and vital signs in newborns with brain injury from oxygen loss, who are receiving cooling treatment. About 84 stable newborns will either get standard care or standard care plus foot reflexology. Re…

This study explores whether a non-invasive brain stimulation technique called tDCS can be practically used during routine speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). Researchers will enroll 30 stroke survivors…

This study tests if a treatment called extracorporeal shock wave therapy (ESWT) can reduce leg muscle stiffness and improve walking in people who have had a stroke. About 85 adults who had a stroke at least 3 months ago will get either real ESWT or a fake (sham) version, plus sta…

This trial tests whether an intensive, personalized speech therapy program (ICAP) helps people with post-stroke aphasia communicate better and feel better. 334 adults who had a stroke at least 3 months ago will be randomly assigned to either ICAP (100 hours over 4 weeks) or stand…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests whether adding functional electrical stimulation (FES) to task-oriented training helps stroke survivors with arm spasticity regain more movement than training alone. All participants receive Botox for spasticity first. The trial will enroll 40 adults who have had…

This study tests whether a non-invasive treatment called focal vibration therapy can reduce shoulder pain in people who have had a stroke. Sixty chronic stroke survivors with shoulder pain will receive either real vibration or a sham procedure, plus standard rehab. The goal is to…

This study tests whether a device that sends specific electromagnetic fields can help people who had a stroke more than 6 months ago improve arm function. 25 adults aged 18-80 with moderate arm weakness will use the device in clinic and at home for 3 months. The main goal is to s…

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests whether a feeding tube placed in the upper esophagus (oro-esophageal) helps stroke patients with swallowing difficulties recover faster than the standard nasogastric tube (through the nose). The trial will include 422 adults who recently had a first ischemic stro…

This study tests whether combining two therapies—blood flow restriction training (using a cuff to partially restrict blood flow during exercise) and brain stimulation (rTMS)—can improve arm and hand function in people who have weakness on one side after a stroke. 69 adults will b…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This early-phase study tests whether a combination of two drugs (chlorpromazine and promethazine) can safely put stroke patients into a hibernation-like state to protect the brain. The trial will enroll 57 adults with acute ischemic stroke who are eligible for clot-removal therap…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard TENS therapy provides extra relief for shoulder pain after a stroke. Forty adults with hemiplegic shoulder pain will receive either TENS alone or TENS plus NMES, alongside their usual rehab. T…

This study looks at how common vision loss is after a stroke and tests a new rehab method. 300 stroke patients will either get standard rehab or standard rehab plus audio-visual stimulation training using a special device. The goal is to see if this extra training helps improve t…

This study tests a special light therapy (850 nm) on 66 adults who had a stroke within the past year and now have trouble speaking or understanding language (aphasia). The goal is to see if shining this light on the head can improve brain activity and language skills. Participant…

This study tests whether special training of the soleus muscle (a calf muscle) can improve walking and muscle activity in people who have had a stroke. Researchers will measure walking speed, balance, and muscle signals in 40 adults aged 45 to 60. The goal is to see if this targe…

This study tests whether using a brain-mapping system (neuronavigation) to guide magnetic stimulation (rTMS) helps stroke patients with arm weakness recover better than standard positioning. Thirty adults who had a stroke 2 weeks to 6 months ago will receive 10 sessions over 2 we…

This study compares 3D-printed dynamic splints to traditional ones for improving arm function in people who have had a stroke. One hundred adults with chronic stroke and mild to moderate arm weakness will receive 20 sessions of task-oriented therapy over four weeks, using either …

This study tests a home-based virtual reality system (MUVITY) to help people who had a stroke 3-12 months ago improve their movement and quality of life. 322 participants will either use the VR system with remote therapist guidance or receive standard exercise instructions. The g…

This study tests a personalized self-rehabilitation program designed to help people with chronic stroke improve their ability to perform daily living activities. Researchers will enroll 158 participants who had a stroke more than 6 months ago. The program involves following a tai…

This study tests whether an artificial intelligence system can help therapists set better rehab exercises for a robotic arm trainer used by stroke patients. One hundred adults who had a stroke within the last six months will receive either AI-guided or therapist-guided robotic th…

This study tests whether shining a low-level laser on the wrist can reduce muscle tightness and improve hand function in 40 stroke survivors aged 45 to 60. Participants will receive either laser therapy plus standard physical therapy or just physical therapy. The goal is to see i…

This study will test whether using smart technologies like brain-computer interfaces and robotic hand therapy can improve recovery in people who recently had a stroke. 200 participants will be split into four groups: three using different high-tech devices and one receiving stand…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study looks at older adults over 65 who are hospitalized after a stroke in a specialized geriatric neurovascular unit in France. Researchers will collect detailed health data, including age, other medical conditions, stroke type, and complications, to describe this populatio…

Severe brain injuries can leave people in a coma or with limited awareness, and doctors struggle to predict who will recover. This study tests whether brain activity during sleep, measured with EEG, can forecast how quickly a patient wakes and how well they recover over a year. R…

This study investigates whether digital health literacy—the ability to find and use health information online—is linked to social participation in adults with hemiplegia after a stroke. Researchers will assess 250 participants using questionnaires to measure digital health litera…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This study looks at whether an AI-based tool that helps doctors shape a microcatheter can improve the safety and success of coil embolization, a procedure to treat brain aneurysms. Researchers will follow about 1,400 adults who are scheduled for this procedure, comparing cases wh…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This study is testing whether a simple, non-invasive brain wave recording (EEG) taken within days of a stroke can help predict how well a person will recover. Researchers will record the brain activity of 400 stroke patients and track their recovery over three to six months. The …

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This study tests whether four popular AI chatbots — ChatGPT, DeepSeek, Gemini, and Claude — can correctly classify surgical risk using anonymous patient vignettes. Researchers compare the AI's risk scores to those given by a panel of senior anesthesiologists. If successful, AI co…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study will use ultrasound to measure the thickness and movement of breathing muscles between the ribs in 65 stroke patients. Researchers will compare the affected and unaffected sides and see how these measurements relate to breathing strength, movement, balance, and quality…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will measure certain proteins in the blood of people who have had a brain hemorrhage (bleeding in the brain) and compare them to healthy volunteers. The goal is to see if these proteins are linked to inflammation after the bleed. No drugs or treatments are being tested…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This study will look at how balance, arm movement, and body awareness are related in 53 people who had a stroke at least 6 months ago. Participants will complete tests like standing on a special platform, reaching tasks, and questionnaires. The goal is to understand these connect…

This study will compare how young adults, older adults, and stroke survivors sense small electrical pulses on their skin. Researchers will measure the smallest changes in pulse frequency, strength, and timing that people can detect. The goal is to gather basic information to impr…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This pilot study will test if training hospital staff in low-resource settings helps them follow a standard stroke care plan. The study plans to enroll 300 adults with acute stroke in hospitals with limited resources. Researchers will measure how well staff stick to the care plan…

This study tests a simple screening tool to help doctors find muscle stiffness (spasticity) sooner after a stroke. Researchers will track how quickly spasticity is detected and whether the tool helps doctors make faster treatment decisions. About 80 adults who recently had a stro…

This study looks at whether using a 3D-printed copy of a patient's brain aneurysm can help doctors plan treatment and avoid problems. About 40 adults with unruptured aneurysms will have their aneurysm printed from scans, then doctors will practice the procedure on the model befor…

This study will track 1000 adults who had a brain bleed from a burst aneurysm. The goal is to learn how often delayed brain injury happens and how doctors currently diagnose and treat it. By comparing different hospital approaches, researchers hope to find better ways to prevent …

This study tests whether a one-week educational campaign called SURA'A can improve how adults recognize stroke symptoms and their intention to seek emergency help. Researchers will enroll 350 adults at primary health centers in Diwaniyah. Participants will receive targeted consul…

This study tests two strategies for removing an external ventricular drain (a tube that drains fluid from the brain) in 170 adults who had a brain bleed. One method clamps the drain shut as soon as it's safe, while the other gradually raises the drain over time. The goal is to se…

This study looks at whether a substance in the blood called BDNF is linked to strokes caused by heart conditions like atrial fibrillation. Researchers will measure BDNF levels in 150 people who recently had a stroke and compare it with heart and brain scans. The goal is to better…

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study explores why stroke survivors often feel extreme muscle fatigue. Researchers will use a gentle, non-invasive brain stimulation technique called tACS to temporarily change brain activity in 120 stroke survivors. Participants will do leg exercises until tired while their…

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This study looks at whether a treadmill that moves each leg at a different speed can help people who had a stroke walk more evenly and faster. About 30 people who had a stroke within the last 9 months will take part. A physiotherapist will guide them through walking exercises on …

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue.…

This study looks at whether people who had a stroke more than six months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and nerve tests to understand who might benefit. Participants will receive electrical muscle stimulation and …

This study looks at whether being at a moderate altitude (like 4,000 meters) can hurt your ability to remember to do things later, called prospective memory. Fifty healthy adults will take memory tests while breathing low-oxygen air or normal air in a chamber. Researchers also wa…

This study looks at 117 people who had a brain bleed (intracerebral hemorrhage) to understand how inflammation and damage to the brain's protective barrier affect recovery. Participants will get special brain scans and blood tests about 10 days after the bleed. The goal is to lin…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at 300 adults with a brain bleed from a ruptured aneurysm. It tests a non-invasive headband to monitor brain blood flow and two nerve treatments (a neck injection and ear stimulation) to see if they improve brain function. The goal is to find better ways to preve…

This study tests whether a gentle magnetic pulse called cTBS can improve attention in people who, after a stroke, ignore one side of their surroundings. Sixty adults with right-brain stroke and left-sided neglect will receive real or fake stimulation to the cerebellum or brain's …

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study tests a digital platform called GetReady that helps doctors and patients track brain aneurysm follow-up data, including symptoms and quality of life. About 200 people with brain aneurysms will use the platform during routine care. The goal is to see if it improves heal…

This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complicatio…

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study will look at medical records of 170 patients aged 70 and older who were in the ICU for a bleeding stroke called aneurysmal subarachnoid hemorrhage. Researchers want to find out which factors are linked to poor recovery or death six months later. The goal is to help doc…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those …

This study tests whether a smartphone app using AI can help personalize rehabilitation for adults who have had a stroke. Thirty participants will use the app daily for six weeks and keep a diary of their exercises. Researchers want to see if people can use the app and if it adapt…

This study looks at whether certain blood test results can help predict how severe a stroke is and how well a person might recover. Researchers will check three different ratios in the blood of 60 adults with acute ischemic stroke. The goal is to see if these simple, routine test…

This study will test whether an artificial intelligence (AI) tool can better predict stroke risk in 1,000 people aged 65-95 with atrial fibrillation, compared to current methods. The AI analyzes health records and heart data to identify high-risk individuals early. The goal is to…

This study watches brain oxygen levels and anesthesia depth in 75 adults during a procedure to fix a brain aneurysm. The goal is to see how these measurements relate to each other and to vital signs like blood pressure. No extra treatments are given—just careful observation to he…

This study will follow 400 people who come to the emergency room with sudden vertigo or dizziness that might be caused by a mini-stroke in the back of the brain. Researchers will track their symptoms, treatments, and outcomes over a year to learn how to better diagnose and manage…

This study tests whether an AI-powered app called HeartBot II can improve women's awareness of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys about their knowledge and confidence in recogn…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This study looks at blood clots removed from 500 stroke patients to understand their composition and how they relate to blood markers, treatment success, and patient recovery. The goal is to learn more about stroke causes and find new ways to dissolve clots. Participants are adul…

This study looks at a protein called GARP in artery plaques from 200 patients having surgery to clear blocked arteries. The goal is to understand how GARP, which is found on platelets and immune cells, might be involved in the inflammation that causes heart attacks and strokes. N…

This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory respon…

This study looks at how the body's immune and inflammatory systems change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammation markers. The goal is to se…

This study looks at how the sense of touch and vibration influence hand movement recovery after a stroke. Researchers will test 90 people with recent stroke and some healthy volunteers using hand dexterity tasks with vibrating rings and brain MRI scans. The goal is to see if addi…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study observes 100 patients having elective brain surgery to clip an aneurysm. Some take daily low-dose aspirin, others do not. Researchers track bleeding during surgery and on CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or …

This study will observe 400 adults who have a stroke within 28 days of a heart procedure, such as a stent or valve replacement. The goal is to learn more about these strokes, including how severe they are and how well current treatments work. No new drugs or devices are being tes…

This study tests whether using less contrast dye during brain scans for unruptured aneurysms can still produce clear images. About 244 adults will be randomly assigned to receive either the standard dye amount or a reduced amount. The goal is to find a safer, more comfortable way…

This study will look at 2000 adults in the Middle East who have had a stroke to understand how common risk factors like high blood pressure, diabetes, high cholesterol, and smoking are in this group. Researchers want to compare these patterns with what is known from Western count…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study looks at 150 adults having emergency clot removal for a stroke. Researchers will measure substances in the blood that show blood vessel damage and inflammation. The goal is to learn how these changes relate to recovery, not to test a new treatment.

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they stick with cholesterol-lowering treatments like statins and diet changes. Researchers want to learn how many patients reach their LDL cholesterol goals and whether better control reduc…

This study uses robots and eye-tracking to measure how vision and body awareness (proprioception) affect arm movement after a stroke. Researchers will follow 425 stroke survivors for six months to understand how these senses recover and how brain damage relates to recovery. The g…

This study aims to discover new reasons why blood clots form in people with heart disease, diabetes, and other illnesses. Researchers will analyze blood samples from 200 patients with narrowed neck arteries to look for markers of cell damage and clotting factors. The goal is to f…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with a persistent blocked artery. Researchers will test if this delayed approach is feasible and if it helps prevent further brain damage. The study involves 50 adults …

This pilot study tests a new, faster MRI technique called Magnetic Resonance Fingerprinting (MRF) for people who have had an ischemic stroke. Standard MRI scans take 20-25 minutes, but for stroke, every minute matters. The study will enroll 10 adults with subacute stroke to see i…

This study will look at the genes of 1,000 people in Brazil—half who had a stroke and half who did not—to find genetic differences that may increase stroke risk. Researchers will use whole genome sequencing to analyze DNA and compare it with international data. The goal is to bet…

This study looks at whether a non-invasive ultrasound test, done within 24 hours of a stroke, can predict how well patients recover. Researchers will measure blood flow in the brain and compare it to neurological improvement over 72 hours. The study involves 50 adults with acute …

This study compares a standard high-field MRI with a portable low-field MRI to see if the portable version can detect brain damage in people in a coma after cardiac arrest. Researchers will scan 60 participants (30 coma patients and 30 healthy volunteers) multiple times over two …

This study looks at how tightness in the ankle muscles (spasticity) after a stroke affects a person's balance, risk of falling, and ability to move around. Researchers will study 68 people who had a stroke at least six months ago, comparing those with mild versus moderate-to-seve…

This study tests a new way to use magnetic stimulation (TMS) to help stroke survivors recover thinking and memory. Instead of a one-size-fits-all approach, researchers will use brain scans to find the exact spot to stimulate for each person. The study will include 10 healthy peop…