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New drug could quiet 'Ticking time Bomb' plaques in the neck

NCT ID NCT07586540

First seen May 15, 2026 · Last updated May 21, 2026 · Updated 2 times

Summary

This study tests whether adding the drug alirocumab to standard statin therapy can shrink dangerous bleeding spots inside fatty plaques in the carotid artery. About 280 people who recently had a mini-stroke or stroke due to a 50-69% blocked neck artery will receive injections every two weeks for 26 weeks. The goal is to see if the drug makes these plaques less likely to cause future strokes.

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Contacts and locations

Locations

  • Aga Khan University

    Karachi, Pakistan

  • Ain Shams University

    Cairo, Egypt

  • Alexandria University, Smouha University Comprehensive Stroke Center

    Alexandria, Egypt

  • Amman Specialized IR Center

    Amman, Jordan

  • Cairo University

    Cairo, Egypt

  • Centre Hospitalier Universitaire Ibn Sina de Rabat

    Rabat, Morocco

  • Department of Neurology, Eskisehir Osmangazi University

    Eskişehir, Turkey (Türkiye)

  • Institut National de Neurologie

    Tunis, Tunisia

  • King Abdulaziz Medical City

    Jeddah, Saudi Arabia

  • King Abdullah Medical City

    Mecca, Saudi Arabia

  • King Khalid University

    Abhā, Saudi Arabia

  • Neurology Department, Al-Azhar University

    Cairo, Egypt

  • Neurology Department, Dr. Lutfi Kirdar City Hospital

    Istanbul, Turkey (Türkiye)

  • Weill Cornell Medicine-Qatar

    Doha, Qatar

Conditions

Explore the condition pages connected to this study.