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Could a common drug prevent brain damage after a stroke?
NCT ID NCT07249853
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether the drug cilostazol can prevent delayed brain injury in people who have had a bleeding stroke from a burst aneurysm. About 316 adults will receive either cilostazol or a placebo for 14 days. The goal is to see if the drug reduces the risk of delayed brain damage and improves long-term recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cilostazol
- What this could lead to
- If it works, this could provide a new way to prevent delayed brain damage after a bleeding stroke, improving recovery.
- What could go wrong
- This is a phase 3 trial, but results are not yet available. The drug may not reduce complications or could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 316 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2025
An estimate. Start dates often move.
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18-80 years. * Diagnosed with subarachnoid hemorrhage (SAH) by computed tomography (CT) scan, and the responsible aneurysm is clearly identified by computed tomography angiography (CTA) or digital subtraction angiography (DSA). * Received aneurysm coil embolization or craniotomy clipping within 72 hours of symptom onset. * Hunt-Hess grade II-IV. * No rebleeding or new intracranial hemorrhage is shown on head CT within 6 hours after surgery. * Understand and follow the procedures of clinical trial, participate voluntarily and sign the informed consent (the informed consent can be signed voluntarily by the person or guardian) Exclusion Criteria: * Multiple aneurysms (\>1aneurysms confirmed by CTA/DSA) * Modified Rankin Scale (mRS) score ≥ 3 before onset * Patients with contraindications to cilostazol use: 1. Allergy to cilostazol 2. Severe heart failure(New York Heart Association (NYHA) Functional Classification Grade III or IV) 3. Coagulation disorders or systemic bleeding (e.g., hemophilia, gastrointestinal bleeding, hemoptysis, etc.) 4. Pregnant or lactating women * Patients with severe organic diseases and an expected survival time of less than 90 days * Severe liver insufficiency or renal insufficiency before randomization * Aneurysm treatment requiring the use of other antiplatelet drugs after interventional therapy * Currently receiving treatment with other investigational drugs or device trials
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, 100070, China
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