Can raising blood pressure after brain bleed surgery boost recovery?
NCT ID NCT07149922
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether raising or lowering blood pressure after aneurysm repair improves outcomes in people with a brain bleed. 750 adults who had surgery within 72 hours will be randomly assigned to different blood pressure targets. Their recovery will be tracked for 6 months using a standard disability scale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- blood pressure management (raising or lowering via fluids and medications)
- What this could lead to
- If it works, this could establish a simple blood pressure target to improve recovery after aneurysm repair for brain bleed patients.
- What could go wrong
- This is an early-stage trial with no phase designation, so results are uncertain. Raising blood pressure may also increase the risk of re-bleeding or other complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 750 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2025
An estimate. Start dates often move.
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\) Aged 18-75 years; 2\) Patients who underwent clipping or endovascular intervention within 72 hours post-ictus; 3\) Intracranial aneurysm diagnosis confirmed by operating surgeons (including neurosurgeons or neurointerventionalists) through imaging findings, intraoperative visualization, or angiography, with subarachnoid hemorrhage (SAH) attributable to the ruptured aneurysm lesion (verified via imaging, xanthochromic cerebrospinal fluid, or intraoperative observation); 4\) Hunt-Hess grade 1-4 at onset; Exclusion Criteria: * 1\) Presence of untreated intracranial aneurysms with rupture risk; 2\) Moderate-to-severe cerebral vasospasm confirmed by pre-enrollment digital subtraction angiography (DSA), transcranial Doppler (TCD), or computed tomography angiography (CTA); 3\) Intracranial massive hematoma (e.g., volume \>30 mL with midline shift \>5 mm) causing severe cerebral herniation, as evidenced by admission CT or other imaging modalities; 4\) Prior cranial neurosurgery for other central nervous system disorders; 5\) Comorbid major systemic diseases or multi-organ dysfunction with life expectancy \<1 year, potentially compromising study implementation or follow-up observations; 6\) Poorly controlled hypertension despite regular antihypertensive medication (e.g., systolic blood pressure \>160 mmHg during pharmacotherapy); 7\) Pre-onset modified Rankin Scale (mRS) score \>2 points, indicating disability from other causes; 8\) Intraoperative major complications including but not limited to massive cerebral hemorrhage, hypovolemic shock, or malignant brain swelling; 9\) Anticipated inability to complete scheduled follow-up assessments within 180 days; 10\) Pregnancy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, 107000, China
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