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Eye ultrasound may reveal best drug to shield brain during aneurysm surgery

NCT ID NCT07660861

Knowledge-focused Sponsor: Fatih Sultan Mehmet Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researchers will use an eye ultrasound to measure changes in brain pressure, aiming to find the safest approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Remifentanil and Esmolol
What this could lead to
If one drug works better, it could become the preferred choice to protect the brain during intubation for aneurysm patients.
What could go wrong
This is a small, early-stage study measuring a surrogate marker (eye ultrasound) rather than direct brain outcomes, so results may not translate to better patient recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 84 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * American Society of Anesthesiologists (ASA) physical status I-III * Scheduled for elective cerebral aneurysm coil embolization under general anesthesia * Planned endotracheal intubation * Ability to provide written informed consent Exclusion Criteria: * Emergency procedures * Hemodynamic instability before induction of anesthesia * Severe cardiac conduction abnormalities or clinically significant arrhythmias * Contraindication or allergy to remifentanil or esmolol * Chronic opioid use or opioid dependence * Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements * Anticipated difficult airway * Pregnancy * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

brain aneurysm intracranial hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral aneurysm unruptured Intracranial pressure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fatih Sultan Mehmet Training and Research Hospital

    Istanbul, Istanbul, 34752, Turkey (Türkiye)

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