Scientists to peek inside brain's immune response after major stroke surgery
NCT ID NCT04763161
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at immune activity in the brain of people who had a severe stroke and needed surgery to relieve pressure. Researchers will compare these patients to others having brain surgery for different reasons. The goal is to better understand the body's inflammatory response after a major stroke. 90 adults will take part.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The target population concerns patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy. Eligibility will be assessed as soon as the first results of the MRI or brain scan carried out as part of the thrombolysis alert by the interventional neurologist or neuroradiologist triggering the treatment, in front of a large ischaemic cerebral accident (\>145 ml).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria Patients: * Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC. Inclusion Criteria Control: \- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach. Non-inclusion Criteria Patients: * HD carried out in a context of acute cerebral haemorrhage * Pre-existing neurological disability: modified Rankin score \> 2 * Patient benefiting from a legal protection measure Non-inclusion Criteria Controls: * Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage. * Patient operated on for an osteomeningeal pathology present at the approach site. * Patient operated on for an infectious cranial or neuro-meningeal pathology. * Patient to be operated on as a result of an intracranial traumatic condition
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
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The official record
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