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Can a simple wrist stimulation reveal consciousness in coma?

NCT ID NCT07506928

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to develop a new EEG-based technique to detect 'cognitive-motor dissociation'—where a patient is aware but cannot move. Researchers will stimulate the median nerve (in the wrist) and analyze brain signals in 50 comatose ICU patients. The goal is to identify those who may have hidden awareness, potentially improving prognosis and care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a new way to detect awareness in patients who appear unconscious, helping doctors give more accurate prognoses.
What could go wrong
This is a small, early-stage observational study (50 participants) that is not yet recruiting. The technique may not reliably detect awareness or improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be aged 18 years or over; * Patients must be admitted to the intensive care unit with a cerebrovascular pathology; * Patients must be in a comatose state with a Glasgow score strictly less than 8, 24 hours after stopping sedation. * Representative of the patient informed of the research and not objecting to it, information and collection of the participant's non-objection if recovery of the ability to understand the content of the information note, * The patient is a recipient of or affiliated with a social security scheme. Exclusion Criteria: * Bilateral lesions of the motor cortex or cortico-spinal fasciculus, * Cutaneous infection of the scalp or any other lesion making surface electroencephalography impossible, * Patient whose short-term survival (48 - 72 hours) seems compromised, * Severe peripheral neuromyopathy, * Severe Acute Respiratory Distress Syndrome at the time of screening, * Hearing-impaired patients with hearing aids, * Pregnant or breastfeeding woman, * Patient under legal protection (persons deprived of their liberty or under guardianship).

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Bordeaux university hospital

    Bordeaux, New Aquitaine, 33000, France

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