Wrist or groin? major study seeks best route for brain scans
NCT ID NCT07544043
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to perform brain angiography: accessing an artery through the wrist (transradial) versus the groin (transfemoral). Over 2,400 people needing this imaging test will be randomly assigned to one method. Researchers will measure success rates, complications, patient comfort, and costs to determine which approach is better.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 2,473 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \> 18 years; 2. Patients requiring full cerebrovascular angiography; 3. Objective evidence indicates the patient is suitable for transfemoral or transradial cerebrovascular angiography, with upper limb vascular ultrasound 4.showing a radial artery internal diameter ≥ 1.5 mm; 5.Modified Rankin Scale (mRS) score ≤ 2 points; 6.Signed informed consent form. Exclusion Criteria: 1. Positive right Allen's test/Barbeau test; femoral artery occlusion (for the TFA group); 2. Local infection or trauma at the puncture site; 3. Coagulation abnormalities: INR \> 1.5 or platelet count \< 50 × 10⁹/L; 4. Presence of access vessel disease or anatomical variation deemed potentially hazardous to the subject, such as aortic arch interruption, subclavian artery occlusion, or aortic dissection; 5. Pregnancy; 6. Planned or recent (within the past 2 weeks) major surgery or severe trauma; 7. Expected survival less than 5 years; 8. Severe cardiac, hepatic, renal, or other organ dysfunction; 9. Contraindication to contrast agents used in cerebrovascular angiography; 10. Inability to comply with follow-up.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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