Bacterial infectious disease

Researchers are comparing ceftobiprole, an intravenous antibiotic, with a standard combination of vancomycin plus aztreonam for treating acute bacterial skin and skin structure infections in hospitalized adults. The trial enrolls adults with serious skin infections such as cellul…

Researchers in India are studying whether a 4-month daily regimen that includes moxifloxacin can cure newly diagnosed, microbiologically confirmed pulmonary tuberculosis as effectively as the standard 6-month treatment. The study enrolls 550 adults aged 18 to 65 who have not yet …

This trial compares the antibiotic tigecycline with two older antibiotics, ampicillin-sulbactam and amoxicillin-clavulanate, in adults with complicated skin or skin structure infections that need intravenous treatment. About 550 participants receive one of the treatments for 4 to…

Researchers compare two 14-day oral antibiotic regimens for eradicating Helicobacter pylori, the bacterium behind most stomach ulcers. One regimen combines bismuth, doxycycline, metronidazole, and esomeprazole; the other adds bismuth to clarithromycin, amoxicillin, and esomeprazo…

This study tested a 9-month treatment plan for people with multidrug-resistant tuberculosis (MDR-TB) in Gabon. The goal was to see if this shorter regimen could cure the disease with fewer side effects. 23 patients aged 15 and older took part, and the study tracked how many were …

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine or a placebo to 625 healthy people aged 5 to 65. The goal was to check safety and how well the vaccine triggers an immune response. Results showed the…

Researchers are testing a new vaccine called LBVD that combines protection against diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib into a single injection. The study will enroll healthy infants aged 6 to 8 weeks, who will receive three doses at 6, 10, and 14 week…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

This trial evaluates a new five-component vaccine (Tdcp) designed to protect against diphtheria, tetanus, and pertussis (whooping cough). It includes about 1,820 participants aged 7 and older, who receive either the experimental vaccine or a control vaccine. The study measures ho…

This early-stage trial is testing a new vaccine called V-212, designed to protect against pneumococcal disease caused by the bacterium Streptococcus pneumoniae. The study involves 60 healthy adults aged 18-45 who will receive either the vaccine or a placebo in three doses. Resear…

This trial tests an experimental oral vaccine, WRSs2, designed to protect against Shigella sonnei, a common cause of severe diarrhea. Healthy adults aged 18-49 receive either the vaccine or a placebo, then are later exposed to the live bacteria in a controlled setting to see if t…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This trial is testing a new tetanus vaccine in healthy adults aged 18 to 43. The goal is to see if the vaccine is safe and triggers a strong immune response, measured by antibody levels one month after vaccination. Participants will receive either the new vaccine or a control vac…

This early-stage study tested a new vaccine called LTB-SA7 designed to protect against infections caused by Staphylococcus aureus bacteria. 129 healthy adults received either the vaccine or a placebo to check for safety and to see if the vaccine triggers an immune response. The s…

This trial investigates how well routine childhood vaccines work in children who have recently finished chemotherapy for cancer. The goal is to see if revaccination can restore protective immunity against diseases like measles, mumps, and whooping cough. Participants receive a se…

This study tests a 13-valent pneumococcal conjugate vaccine in healthy children aged 15 months to 17 years. The goal is to see if the vaccine is safe and triggers a strong immune response against 13 types of pneumococcal bacteria. Participants receive one or two doses, and resear…

This study tests an experimental vaccine called GBS-NN/NN2 against Group B Streptococcus (GBS), a bacteria that can cause serious infections in newborns. The trial includes pregnant women both with and without HIV, giving two doses between 26 and 30 weeks of pregnancy. Researcher…

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tested a new combination vaccine designed to protect healthy infants against five types of meningococcal bacteria (A, B, C, W, and Y) that can cause serious infections like meningitis. Over 700 infants received different doses or combinations of the vaccine to check sa…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study looked at how well the MenBVac vaccine protects children against a specific type of meningitis B bacteria. Researchers measured the immune response in 218 children who had already received five doses of the vaccine. The goal was to see if the children had enough antibo…

This study tested whether a fourth dose of the MenBVac vaccine boosts protection against meningitis B in children. Researchers measured immune responses in 120 children before and after the booster. The goal was to see if the vaccine maintains protective antibody levels over time…

This study tested a new vaccine (VLA15) to prevent Lyme disease, a tick-borne illness. About 12,500 healthy people aged 5 and older in high-risk areas received either the vaccine or a placebo. The goal was to see if the vaccine safely reduces Lyme disease cases compared to no vac…

This study looked at 117 children aged 4-8 who had received four doses of the MenBVac vaccine against meningitis B. Researchers measured how many still had protective antibodies four years after the last dose. The goal was to see if the vaccine's immunity lasts over time.

This large study tested a typhoid conjugate vaccine called TyphiBEV in over 72,000 people aged 1 to 30 years in Vellore, India. The goal was to see if the vaccine reduces the number of confirmed typhoid fever cases in vaccinated communities compared to unvaccinated ones. The tria…

This study tested a new vaccine called V116 in 882 children and teenagers aged 2 to 17 who have a higher risk of pneumococcal disease due to conditions like diabetes or chronic lung disease. The goal was to see if V116 is as good as or better than the current vaccine PPSV23 at tr…

This completed study tracked over 10,000 people in Thailand who received the Boostagen® vaccine, which protects against tetanus, diphtheria, and whooping cough. Healthcare workers reported any side effects to see how safe the vaccine is in everyday use. The study also looked at p…

This completed Phase 3 study tested a new vaccine called V116 in 518 adults aged 18 to 64 who are at increased risk for pneumococcal disease due to conditions like diabetes or chronic lung disease. The vaccine targets 21 strains of the bacteria that cause pneumonia and other infe…

This study tested a two-step vaccine approach in 70 adults who had their spleen removed. Participants received one shot of a conjugate vaccine followed by a second shot of a polysaccharide vaccine two months later. The goal was to see if this combination triggers a strong immune …

This early-stage trial tested whether a new whole-cell pneumonia vaccine is safe for people. Thirty healthy adults received either the vaccine or a placebo and were monitored for 30 days. The main goal was to check for side effects like pain, fever, or headache. This study does n…

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

This completed Phase 2 trial tested fecal microbiota transfer (FMT) – a freeze-dried product made from healthy donor stool – in 40 women with recurrent urinary tract infections (UTIs). The goal was to see if FMT could prevent future UTIs by restoring healthy gut bacteria. Researc…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

In sub-Saharan Africa, tuberculosis often causes sepsis in people living with HIV, and many die within days. This phase 3 trial tests two changes to standard care: starting anti-TB therapy right away instead of waiting for test results, and using a higher, sepsis-specific dose in…

Researchers are testing a drug called sonelokimab in adults with moderate to severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and abscesses. The trial compares sonelokimab, given by injection, with a placebo and with adalimumab, an existing trea…

This trial tests whether adding methotrexate to the standard steroid prednisolone better controls erythema nodosum leprosum (ENL), a painful and often recurring complication of leprosy. Adults aged 18 to 65 with active ENL will receive either prednisolone alone or prednisolone pl…

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This trial tests whether an oral antibiotic called tebipenem-pivoxil works as well as the standard IV antibiotic ceftriaxone for children with shigellosis, a severe diarrheal disease, when first-line treatment fails. The study enrolls children aged 24 to 59 months who have not im…

This trial tests whether giving a higher dose of the antibiotic rifampicin (35 mg/kg) can increase drug levels in the fluid around the heart and clear tuberculosis bacteria faster than the standard dose (10 mg/kg). The study enrolls adults with suspected tuberculous pericarditis,…

This trial tests an experimental antibiotic called BTZ-043 in adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants take the drug by mouth once daily for 14 days, and researchers compare it to a standard combination treatment. The main goal is to check …

This trial tests whether adding tinidazole to the standard antibiotics doxycycline or azithromycin cures non-gonococcal urethritis (NGU) better than antibiotics alone. NGU is a bacterial infection causing inflammation of the urethra, often passed through sex. About 300 men aged 1…

This trial tests a new combination of four drugs, called BPaMZ, for treating tuberculosis. People with drug-sensitive TB receive BPaMZ for 4 months, compared to the standard 6-month regimen. People with drug-resistant TB receive BPaMZ for 6 months. The study measures how well the…

Researchers are testing whether muffins enriched with pomegranate peel powder can help people with stomach ulcers caused by H. pylori infection. The trial gives participants either a regular whole wheat muffin or one with 1.5 or 3 grams of pomegranate peel powder, alongside their…

This trial tests whether giving thiamine (vitamin B1), vitamin C, or both, alongside standard care, can reduce harmful inflammation and tissue damage in adults with sepsis. The study will measure blood markers of inflammation and tissue remodeling before and after 72 hours of tre…

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock right in the ambulance could lower the number of deaths. The treatment included early antibiotics and fluids to support blood pressure. The study involved 398 adults and measured…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This phase 2 trial investigates whether paroxetine, a common antidepressant, can improve cardiovascular function in patients with septic shock. Septic shock causes dangerously low blood pressure and poor response to standard vasopressor drugs. The study will give paroxetine or a …

This trial explores whether a bioceramic sealer, used alone, can effectively fill root canals in baby molars when the permanent successor is missing. Thirty healthy children with deep decay in a lower second baby molar will receive the treatment and be followed for up to two year…

This study is testing a single dose of the antibiotic Vabomere in 39 children from birth to under 18 years old who have serious bacterial infections. The goal is to find the right dose and check how safe and tolerable the drug is. All children are hospitalized and receiving other…

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This trial compares the antibiotic rifapentine against the standard drug rifampin during the first 8 weeks of treatment for pulmonary tuberculosis. About 334 adults with TB bacteria in their sputum are randomly assigned to receive either the standard regimen or one with rifapenti…

This virtual trial tests whether a daily prebiotic and probiotic supplement can relieve symptoms of bacterial vaginosis and yeast infections, such as itching, odor, and abnormal discharge. Women aged 25 and older with these concerns will take two capsules daily for 30 days. The s…

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This study tests whether stable patients with a common blood infection (gram-negative bacteraemia) can safely switch from IV antibiotics to oral pills within 72 hours. Researchers will compare early oral therapy to continued IV treatment in 720 adults. The main goal is to see if …

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This study looks at how a shorter tuberculosis (TB) treatment regimen works for children and adolescents with non-severe TB in Zambia. It involves children, caregivers, health workers, and policymakers to understand how well the regimen is accepted, followed, and feasible in real…

This trial examines whether using a quick nasal swab to check for MRSA bacteria can help doctors decide how long to treat pneumonia patients with the antibiotic vancomycin. The study compares the duration of therapy and costs before and after implementing this screening test. Par…

This trial tests two approved antibiotics—azithromycin (a single dose) and doxycycline (twice daily for a week)—to see which is more effective at curing genital chlamydia in young people aged 12-21 living in youth correctional facilities. Participants provide urine samples over a…

This trial compares the antibiotic faropenem to a standard combination of co-amoxiclav and clarithromycin in adults with community-acquired bacterial pneumonia. Participants are randomly assigned to one of two treatment groups for seven days, then followed for four weeks. The stu…

This study looks at the best time to add the drug vasopressin for people with septic shock—a life-threatening drop in blood pressure from infection. About 2,050 adults will be treated using either an earlier or later threshold for starting vasopressin. The goal is to see which ap…

This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as …

This study tests whether a higher dose of the oral antibiotic cephalexin can better treat cellulitis, a common skin infection, in adults visiting the emergency room. About 446 participants will receive either a high or standard dose to see if it reduces the need for changing anti…

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tests whether injecting a diluted hydrogen peroxide solution or steroids into the chest can break up scar tissue and free a trapped lung, compared to a standard surgical scraping procedure (thoracoscopy). The trial enrolls adults aged 18-62 with a lung infection that h…

This trial tests whether a 7-day course of vonoprazan combined with high-dose amoxicillin and clarithromycin can eradicate H. pylori infection as effectively as the current 14-day extended sequential therapy. About 628 adults with H. pylori infection will be randomly assigned to …

This trial tests whether using a low-power laser during a pulpotomy (removing infected pulp from a tooth) can improve healing and root formation in children aged 6 to 14 with painful, irreversible pulpitis in immature permanent molars. Participants receive either laser treatment …

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study tests whether a newer, easier-to-use material called NeoPUTTY works as well as the standard MTA for saving permanent back teeth with severe nerve inflammation in children aged 9 to 14. Both materials are used to cover the remaining healthy nerve after removing the dise…

This trial compares two types of rotary files (Kedo-Nano Plus and Kedo-S Square) with traditional hand files for root canals in children's baby molars. About 60 healthy kids aged 5-8 with infected molars will receive a pulpectomy using one of the three tools. Researchers will che…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study tests whether placing the final abutment once during dental implant surgery, without removing it during healing, reduces bone loss around the implant compared to standard repeated disconnections. Researchers will also measure patient satisfaction and analyze mouth bact…

This study looked at how safe and tolerable the drug bedaquiline is for children and teens with rifampin-resistant tuberculosis, including those also living with HIV. Fifty-four participants received bedaquiline along with their regular TB treatment for 24 weeks. Researchers meas…

This study tests whether adding delpazolid to standard treatment can reduce bacterial levels in people with hard-to-treat Mycobacterium abscessus lung infections. Participants take delpazolid tablets daily for 12 weeks, with the option to continue up to one year if there is clini…

This trial compares two methods of giving hydrocortisone to adults with septic shock—a life-threatening drop in blood pressure due to infection. One group receives the steroid as a continuous drip, the other as intermittent shots every six hours. Researchers track 28-day survival…

This pilot study compares a new decolonization regimen using polyhexanide (nasal gel and body foam) to the standard mupirocin and chlorhexidine treatment for reducing Staphylococcus aureus bacteria before elective spine surgery. The trial includes 24 adults who carry Staph bacter…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This trial investigates whether the dose of rifapentine given to children aged 2 to 11 with latent tuberculosis infection is adequate. Researchers measure the drug level in a single blood sample taken 24 hours after a dose and compare it to levels in adults. The goal is to ensure…

This study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…

This study looks at whether giving the Tdap vaccine every 3 months for a year is safe for healthy plasma donors. Normally, this vaccine is given once every 10 years. The goal is to see if more frequent vaccination produces high levels of tetanus antibodies in the plasma, which co…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study compares two ways of making sure people with tuberculosis (TB) take their medicine correctly: traditional in-person observation by a healthcare worker versus electronic observation using live video or recorded videos on a computer or phone. The trial involves 216 TB pa…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This trial investigates whether giving two different pneumonia vaccines—one followed by another a year later—boosts immune protection more than a single vaccine alone in adults who have had their spleen removed. People without a spleen are at higher risk for serious pneumococcal …

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested whether a combination of topical antibiotics and antiseptic washes could reduce staph bacteria on the skin of Native American adults living on or near tribal lands. Participants were at high risk for staph infections due to diabetes, obesity, or recent infection…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested whether giving a single high dose of vitamin B12 (5 grams) to 20 adults with septic shock is feasible and safe. Patients received either vitamin B12 or a placebo (saline) alongside standard care. The main goal was to see if the study procedures could be complete…

This study tested a drug called GM-CSF in 166 ICU patients who had severe sepsis or septic shock and a weakened immune system. The goal was to see if the drug could reduce the number of new infections acquired in the ICU. Patients received either GM-CSF or a placebo, and research…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested a single dose of the drug pretomanid in 32 children with rifampicin-resistant tuberculosis (TB). The goal was to see how the drug moves through the body and whether it is safe when added to their regular TB treatment. The children were monitored for 48 hours aft…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study tested whether giving very high doses of vitamin C to people with sepsis (a severe infection that can cause organ failure) could reduce the risk of death within 28 days. 234 adults in the ICU received either vitamin C or a placebo for up to 4 days. The main goal was to…

This study tested a structured plan to remove excess fluid early in patients with septic shock. 170 ICU patients were randomly assigned to either the fluid removal protocol or standard care. The goal was to see if the plan could safely reduce fluid buildup by day three, which mig…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This study tested whether a visual storytelling sticker on antibiotic packaging helps adults with urinary tract infections (UTIs) take all their medicine. 358 adults in Pakistan were randomly assigned to get either the sticker or usual care. The goal was to see if the sticker imp…

This study tested a device that delivers antibiotics directly to an infected hip or knee joint for 7 days after replacement surgery. 76 adults with joint infections were randomly assigned to get either the local antibiotic irrigation plus standard care, or standard care alone. Th…

This study tested whether paramedics can improve survival by giving antibiotics and fluids to sepsis patients before reaching the hospital. Over 2,000 adults with suspected sepsis and low blood pressure were enrolled. The goal was to see if early treatment in the field reduces de…

This study tested whether an inhaled antibiotic (tobramycin), taken alone or with an oral antibiotic (ciprofloxacin), can permanently clear Pseudomonas aeruginosa infections from the lungs of people with bronchiectasis. The trial involved 371 adults and compared these treatments …

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receiv…

This study tested whether tamsulosin (Flomax) can reduce the risk of urinary retention and catheter-related infections in men aged 50 and older after elective surgery. Participants received either tamsulosin or a placebo after their catheter was removed. The goal was to see if th…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This study tested whether an early, computer-guided dosing strategy for vancomycin helps children with MRSA infections reach the right drug levels faster than the usual approach. 100 children aged 1 month to 16 years took part. The goal was to improve treatment effectiveness whil…

This study looked at whether it is safe to stop giving annual azithromycin to communities with low levels of trachoma, an eye infection that can cause blindness. Over 3,900 people in Niger took part. Researchers compared stopping treatment after at least 5 years versus continuing…

This study tested whether injecting the antibiotic gentamicin directly into swollen lymph nodes helps people with cat scratch disease recover faster. 75 participants received either the injection or a placebo, along with standard oral antibiotics. The goal was to see if the injec…

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a new medicine called AP-SA02, given through a vein, along with standard antibiotics for adults with a Staph blood infection. The main goal was to check if the combination is safe and tolerable. Researchers also looked at whether it helped clear the infection fa…

This pilot study tested whether adding methylene blue to standard care is feasible for adults with septic shock in the intensive care unit. The main goal was to see if a larger trial could be done, not to prove the treatment works. Fifty patients took part, and the study looked a…

This study tests whether a special donor plasma product called OctaplasLG can help people with septic shock who develop blood clotting problems. Sixty participants will receive either OctaplasLG or a placebo (salt water) to see if the treatment improves clotting and outcomes. The…

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This large study tested whether a 'balanced' fluid (Lactated Ringer) is better than normal saline for children with septic shock. Over 9,000 kids participated across multiple hospitals. The goal was to see which fluid reduces the risk of serious kidney problems or death within 30…

This study looked at whether giving two antibiotics together (meropenem and azithromycin) helps children with drug-resistant typhoid fever get better faster than using just one. 90 children aged 6 months to 5 years with confirmed typhoid took part. The main goal was to see how qu…

This study looked at how the antibiotic cefiderocol works in hospitalized infants under 3 months old with suspected or confirmed gram-negative bacterial infections. Researchers measured drug levels in the blood and checked for side effects in 30 babies. The goal was to find the r…

This large trial tested whether a lower-chloride fluid (Ringer's Lactate) reduces death and kidney injury compared to standard saline in 1,113 adults with septic shock. Participants received either fluid within 6 hours of hospital arrival. The study aims to settle a long-standing…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study compared two treatments for pleural infection, a serious lung condition where infected fluid builds up. One group received standard fibrinolytic drugs (alteplase and DNase) to break down clots, while the other group received simple saline (salt water) irrigation to flu…

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested whether vaginal capsules containing live lactobacilli (good bacteria) are safe and tolerable for treating bacterial vaginosis (BV), a common infection. Fifty-seven women with BV took either the lactobacillus capsules or the standard antibiotic metronidazole. The…

This study tested whether vaginal probiotic capsules can cure bacterial vaginosis (BV) better than a placebo. 402 women with BV took part. The main goal was to see if more women were cured 21-30 days after treatment with the probiotic compared to placebo. The trial was completed …

This study tested whether vaginal capsules containing two types of Lactobacillus probiotics can treat bacterial vaginosis, a common vaginal infection. Sixty-six women received either the probiotic capsule or a placebo. The goal was to see if the probiotics could restore normal va…

This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal …

This study tested whether adding an inhaled antibiotic (ALIS) to standard oral antibiotics helps adults with a new diagnosis of a hard-to-treat lung infection caused by MAC bacteria. About 425 adults took part. The main goal was to see if the combination improved breathing sympto…

This study tested whether an older antibiotic, temocillin, works as well as the standard treatment meropenem for bloodstream infections caused by drug-resistant bacteria. 334 adults with these infections were randomly assigned to receive one of the two antibiotics for 7 to 14 day…

This study tested whether a combination of two antibiotics (azithromycin and cefixime) works better than azithromycin alone for treating uncomplicated typhoid fever in South Asia. Over 2,100 patients took part across Bangladesh, India, Nepal, and Pakistan. Researchers measured tr…

This study tested whether a simpler two-drug treatment (tegoprazan and amoxicillin) works better than the standard four-drug therapy for eradicating H. pylori, a bacteria that can cause stomach ulcers. 370 adults with H. pylori infection were randomly assigned to one of the two t…

This study looked at whether giving antibiotics for a shorter, personalized time is as safe and effective as the usual 7-day course for full-term newborns with a suspected infection. About 488 babies took part across 18 hospitals. The goal was to see if shorter treatment could re…

This study looked at 508 adults with H. pylori infection to see if a 7-day triple therapy (vonoprazan, amoxicillin, tetracycline) works as well as a 14-day dual therapy (vonoprazan, amoxicillin). The goal was to compare how often the infection is cleared and how many side effects…

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested two different 14-day drug combinations to treat Helicobacter pylori, a bacteria that causes stomach inflammation and ulcers. Over 750 adults were randomly assigned to either a triple therapy (omeprazole, amoxicillin, clarithromycin) or a quadruple therapy (omepr…

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are…

This study compared 6 weeks versus 12 weeks of antibiotics for people with infected hip or knee prostheses who had surgery. Researchers wanted to see if the shorter course was just as effective at curing the infection without increasing relapse. The trial enrolled 410 adults acro…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This pilot study tested whether giving a sodium lactate solution to people with septic shock could help manage their fluid balance. Septic shock is a life-threatening condition where blood pressure drops dangerously due to infection. The study involved 59 participants and compare…

This study tested whether a computer program called BestDose could help doctors give the right amount of the antibiotic amikacin to patients with septic shock. The goal was to get drug levels in the ideal range after the second dose. 180 patients took part, and researchers checke…

This study tested whether transplanting pulp tissue from a healthy tooth into a dead one could restore vitality. Twenty-one adults with dead single-rooted teeth received either a pulp transplant, a pulp transplant with growth factors, or standard root canal treatment. The goal wa…

This study tested a therapeutic vaccine called RUTI in 41 adults with active pulmonary tuberculosis. Participants received either the vaccine or a placebo alongside their regular antibiotic treatment. The goal was to see if the vaccine could boost the immune system to kill bacter…

This study compared two common antibiotics, doxycycline and TMP-SMX, for treating uncomplicated skin infections like boils and cellulitis. 269 people aged 9 to 85 took one of the drugs for 7 days. Researchers checked if the infection cleared up early, at the end of treatment, and…

This study tested whether an oral probiotic supplement could help restore healthy bacteria in the vagina. It included 32 women aged 35-43 with vaginal imbalance and fertility concerns. Researchers measured how well the probiotic colonized the body and its effects on immune and an…

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study tested whether a non-invasive arm cuff procedure, called remote ischemic conditioning, could reduce organ failure in 180 adults with septic shock. The cuff was inflated and deflated in cycles to mimic brief blood flow restriction. The goal was to see if this could prot…

This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or…

This study tested two different antibiotics—clarithromycin or moxifloxacin—alongside standard drugs to treat a rare lung infection caused by M. xenopi bacteria. Researchers tracked whether patients' sputum samples became bacteria-free after 6 months. The goal was to find the more…

This study tested whether applying vancomycin powder directly to the surgical wound during brain surgery can reduce infections. Over 1,100 adults having neurosurgery were randomly assigned to receive either the topical vancomycin or standard care. The main goal was to see if the …

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The goal was to see if the new pill can control HIV just as well as the current standard treatment. The study measure…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested a personalized approach to fluid management in 535 adults with septic shock. Doctors used a 'mini-fluid challenge'—a small amount of albumin given quickly—to check if more fluids would help, aiming to avoid fluid overload. The goal was to see if this tailored me…

This phase IIb trial tested an experimental antibiotic called delpazolid, added to a standard three-drug regimen (bedaquiline, delamanid, moxifloxacin), in 76 adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. The main goals were to check safety and how the drug …

This study tested whether measuring a blood marker called procalcitonin (PCT) could help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 newborns were included, and the goal was to reduce antibiotic use by 30% without increasing infection recu…

This study tested four different short antibiotic courses in 1,000 women with uncomplicated lower urinary tract infections. Participants received either a two-day course of fosfomycin, a three-day course of pivmecillinam, a five-day course of nitrofurantoin, or a single dose of f…

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

Researchers are testing whether ultrasound can reliably show joint damage and inflammation in people with septic arthritis, a painful joint infection. The trial follows 28 adults with septic arthritis in the shoulder, elbow, wrist, hip, knee, or ankle. Participants receive standa…

Researchers in Basel are testing whether a blood marker called HNL can help emergency doctors quickly tell whether an infection is bacterial or viral. The study will enroll about 516 adults with suspected infection and signs of physiological disturbance. Doctors will measure HNL …

Researchers are testing a portable device called Truenat MTB Plus/COVID-19 to see if it can accurately detect both tuberculosis and COVID-19 from the same sample. The study will enroll about 2,000 adults who have symptoms like a long-lasting cough, fever, or weight loss, which co…

This study is testing three new diagnostic tests to see if they can correctly identify a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will use leftover samples from over 3,000 people who already tested positive for gonorrhea. If the te…

This study evaluates whether two newer line probe assays, the YD REBA MTB-MDR and Hain Genotype MTBDRplus V2, perform as well as the older Hain Genotype MTBDRplus V1 in detecting drug-resistant tuberculosis. Researchers will test stored, de-identified samples from adults with sym…

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional te…

This study asks whether changes in blood renin levels over the first 72 hours can predict death in septic shock patients better than the standard lactate test. Researchers will measure renin and lactate at enrollment and at 24, 48, and 72 hours in 60 adults with septic shock. The…

This study is testing whether a new urine analysis device, the Sysmex UF-5000, can accurately measure inflammation markers in healthy men. The goal is to establish a baseline for what's normal, which could help develop a quick, non-invasive test for urethritis, a common infection…

This trial compares two endoscopic techniques—standard white light endoscopy and magnifying endoscopy with narrow-band imaging—to see which better identifies the status of Helicobacter pylori (Hp) infection. About 384 participants will undergo both procedures, and the accuracy of…

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This trial tests whether a rapid diagnostic test called Reveal can improve outcomes for hospitalized patients with gram-negative bloodstream infections. The test measures bacterial growth by detecting gases they release, giving results in about 5 hours instead of the usual 2-3 da…

This study investigates whether three common lab tests — blood levels of ESR and CRP, plus a leukocyte esterase dipstick test on joint fluid — can reliably diagnose chronic infection in people who have had a total joint replacement. The researchers will compare the test results a…

This study evaluates a rapid viability test for tuberculosis bacteria in sputum samples. The goal is to see if this test can accurately tell whether a patient is still contagious, compared to the standard culture method that takes weeks. If the test works, it could help doctors d…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tested a new skin test called C-TST to find latent (hidden) tuberculosis infections in 300 adults in Indonesia who were close contacts of TB patients. Participants received both the skin test and a standard blood test (IGRA) to see how well the new test worked. The goa…

This study tested a new molecular test (iiPCR) to diagnose scrub typhus, a bacterial infection spread by mites. Researchers compared the test's accuracy against standard methods in 345 participants in Thailand. The goal was to see if this tool could provide faster, reliable diagn…

This study looked at 173 adults on ventilators to see if combining advanced germ-detection tests with a patient's immune response can improve diagnosis of ventilator-associated pneumonia. Researchers compared several molecular tests and host-response markers to standard clinical …

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who were unwell and suspected of having TB or pneumonia took part. The goal is to…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study tested two ways of preparing tissue samples to find bacteria in bone and joint infections. One method grinds the sample, while the other uses standard techniques. Researchers wanted to see which method is more accurate at diagnosing infections. The study involved 122 p…

This study tested a new rapid test (OCEAN Dx) to identify bacteria in the blood of 110 ICU patients with suspected sepsis. The goal was to see if it works as well as standard blood cultures, which take 48-72 hours. A faster result could help doctors choose the right antibiotics s…

This study tested a new, low-cost tool called the Intensive Care Infection Score (ICIS) to see if it can better detect bacterial infections in burn patients compared to standard blood tests. Researchers studied 97 adults and children hospitalized for burns. The goal was to improv…

This study looked at whether a combination of 7 biomarkers in the blood can more accurately diagnose severe bacterial infections in children aged 7 days to 36 months with fever. Researchers enrolled 983 children and compared the biomarker panel's performance against standard test…

This study aimed to create a quick, simple test to diagnose tuberculous meningitis (TBM) in children. TBM is a severe form of TB that affects the brain and is hard to detect with current methods, especially in places with limited resources. Researchers tested 51 inflammatory mark…

This completed study tested a new rapid diagnostic tool to quickly identify antibiotic-resistant bacteria in wounded warriors and veterans. Over 2,200 participants provided samples from blood, lungs, or skin. The goal was to see if the test could accurately detect resistant bacte…

This study tested a new, portable blood culture system called BactInsight in hospitals in Benin and Burkina Faso. The system uses a battery-powered device to detect bacteria in blood samples faster than current manual methods. Researchers compared it to standard lab tests in over…

This completed study tested several tuberculosis (TB) diagnostic tools in over 14,000 people across seven countries. The goal was to find tests that are accurate enough to use in local clinics, without needing special lab equipment. Researchers looked at a simple blood test for C…

This study looked at better ways to screen teenagers (ages 15-21) for chlamydia and gonorrhea when they visit emergency departments. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to find the most effective and cos…

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested whether a combination of 11 blood markers can more accurately diagnose late-onset sepsis in newborns in the NICU. Current methods are slow and often lead to unnecessary antibiotic use. Researchers enrolled 233 newborns with signs of infection to see if this biom…

Researchers compare one French middle school that used the e-Bug educational programme with other schools in the region to see whether classroom lessons about vaccination relate to higher HPV and meningococcal ACWY vaccine coverage. The study uses only aggregated, anonymised vacc…

This completed trial tested a device that uses light to kill germs in the nose before surgery, aiming to prevent surgical site infections. Over 400 adults having major surgeries received either the light treatment or standard care. Researchers tracked infections and side effects …

This study tested a new way to prevent surgical site infections by using a special light treatment inside the nose just before surgery. Over 4,700 adults having major surgeries like heart, spine, or joint replacement took part. The goal was to see if this light therapy reduces in…

Researchers are comparing two antibiotic combinations given before vascular surgery to see which better prevents MRSA infections. Adults scheduled for procedures such as carotid surgery or dialysis access creation receive either vancomycin plus cefazolin or daptomycin plus cefazo…

This trial tests a strategy called expedited partner therapy (EPT) for men who have sex with men in Peru. When a participant is diagnosed with gonorrhea or chlamydia, they receive antibiotic packets to give to their recent sexual partners, so those partners can get treated withou…

This phase 3 trial compares a new lab-made antibody, TNM002, with the standard human tetanus immunoglobulin for preventing tetanus in adults with dirty or contaminated wounds. Participants receive one injection of either treatment, and researchers measure whether their blood reac…

This trial is testing the safety of the Menhycia® vaccine in about 3,000 healthy 3-month-old infants who have not yet received any epidemic meningitis vaccine. The infants will receive three doses of the vaccine at least one month apart, with an optional booster at 12 months of a…

This trial tests whether giving children a single dose of the antibiotic azithromycin right after a household member tests positive for cholera can prevent them from getting infected. The study enrolls children aged 1 to 15 who share cooking facilities with a cholera patient. Res…

This early-stage trial is testing an experimental vaccine designed to protect people aged 6 and older against diphtheria, tetanus, and pertussis (whooping cough). The study will enroll 180 participants to check the vaccine's safety and how well it triggers an immune response. Som…

This trial is testing an experimental vaccine called Menhycia, designed to protect against four types of meningococcal bacteria (A, C, Y, and W135) that can cause meningitis and bloodstream infections. The study involves about 1,480 healthy adults aged 18 to 55, who will receive …

This trial is testing an experimental vaccine designed to protect against four strains of the bacteria that cause meningococcal meningitis, a serious infection of the brain and spinal cord. The study involves around 840 participants aged 7 to 17, who will receive either the new v…

This trial is testing whether a single dose of an experimental tetanus vaccine is safe and triggers a protective immune response in adults aged 18 and older. Participants will receive either the new vaccine or a control vaccine, and researchers will measure antibody levels and mo…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the pas…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This completed study tested a new public health pack to find and prevent tuberculosis (TB) early in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The pack included active screening, treatment for active TB, and preventive therapy for th…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested whether a new vaccine against certain E. coli bacteria (ExPEC9V) can be given at the same time as a high-dose flu shot in adults aged 65 and older. The goal was to see if the immune response to both vaccines remains strong when given together. About 959 particip…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This study tested a two-step vaccine approach to prevent pneumococcal infections in 26 adults with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The vaccines, Prevenar and Pneumovax, were given in a prime-boost sequence to boost immune protection. …

This study tested a special dressing coated with a spider-silk-like chemical (DACC) to see if it prevents infections after vascular surgery. Over 700 adults in the UK were randomly assigned to get either the DACC dressing or a standard one. Researchers checked for infections at 3…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tested whether a structured collaboration between pharmacists and doctors could improve pneumococcal vaccination rates in patients at high risk for infection. Over 600 hospitalized adults with chronic conditions or weakened immune systems took part. The pharmacist revi…

This study looked at whether cranberry gel capsules can prevent E. coli infections from urinary catheters placed during pelvic surgery. About 270 adults took part. The idea was that cranberry might stop bacteria from sticking to the catheter, reducing infection risk.

This study tested whether giving an antibiotic (clindamycin) to pregnant women with bacterial vaginosis (a common vaginal infection) before 13 weeks of pregnancy could lower the chance of very early preterm birth. Over 3,000 pregnant women took part. The goal was to see if early …

This study tested whether giving mothers a single 2-gram dose of the antibiotic azithromycin during labour could reduce the risk of skin and soft tissue infections in their babies during the first three months of life. Over 2,000 pregnant women in Fiji took part, receiving either…

This study in Blantyre, Malawi, compares two schedules of the pneumococcal conjugate vaccine (PCV13): the current 3-dose schedule without a booster (3+0) versus a 2-dose schedule with a booster at 9 months (2+1). The goal is to see if the booster reduces carriage of vaccine-type …

Researchers are testing whether oral N-acetylcysteine (NAC) can reduce signs of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis. The trial enrolls 64 adults who have had fever for three to five days and a confirmed Leptospira infe…

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either c…

Researchers compare two root canal file systems, ProTaper Gold and ProTaper Ultimate, to see if they differ in how much pain patients feel afterward. The trial enrolls 40 adults with permanent lower molars diagnosed with symptomatic irreversible pulpitis and apical periodontitis.…

Researchers compare three sealers used during root canal treatment, Totalfil, NeoSealer, and AH-Plus, to see how much pain patients feel afterward. The study includes 39 people with painful, inflamed lower molars that need a root canal. Each participant receives one of the three …

Researchers compare two materials used in pulpotomy, a procedure that removes inflamed pulp from a tooth and covers the remaining tissue. Adults with deep cavities and signs of pulp inflammation in lower first or second molars receive either BIO MTA+ or Well-Root PT. The study me…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study looks at whether rinsing with a green tea extract (EGCG) during a tooth-saving procedure (pulpotomy) can lower pain and improve success rates in adults with severe tooth decay. 64 participants with deep cavities will receive one of two rinses and one of two filling mat…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This trial tests whether warming up dental filling materials before placement can reduce inflammation inside the tooth and lessen pain after treatment. Thirty adults with deep cavities will receive fillings at different temperatures — one group gets a special flowable composite p…

This trial compares two ways of giving the anti-inflammatory drug piroxicam to control pain after root canal treatment: a standard oral pill versus an injection into the ligament around the tooth. Adults with a toothache caused by irreversible pulpitis will receive one of the two…

This study tests whether using cooled liquid to clean the inside of a tooth during root canal treatment can reduce pain afterward. It includes adults with certain tooth conditions who need a root canal. The approach involves comparing cooled versus room-temperature irrigation to …

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

This study tests an investigational drug called CBL-514, given as an injection into areas of cellulite on the thighs. The goal is to see if it can safely reduce the severity of cellulite dimpling. The trial involves women aged 18 to 64 with mild to moderate cellulite. Researchers…

This study tests whether taking ibuprofen before a root canal can improve the effectiveness of local anesthesia in people with severe tooth inflammation (irreversible pulpitis). Participants will receive either ibuprofen or a placebo before the procedure, and pain levels will be …

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study compared two common painkillers—diclofenac sodium and ibuprofen—for managing pain after a root canal. Sixty adults with irreversible pulpitis received one of the two drugs right after treatment, and their pain was tracked for 48 hours. The goal was to see which drug pr…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study looked at 146 adults with painful tooth inflammation who needed root canal treatment. It compared two different tools (WaveOne and ProTaper) to see which one leads to less pain after the procedure. Patients rated their pain at several times over a week. The goal is to …

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were mea…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study tested whether a whole-body compression bandage could help reduce fluid buildup in ICU patients with severe sepsis or septic shock. 64 patients on mechanical ventilation received the bandage within 12 hours of admission. Researchers tracked daily fluid balance and chec…

This study looked at whether women who had surgery for prolapse or incontinence could safely remove their urinary catheter at home one day after surgery, instead of waiting 3-4 days. 128 women who failed a voiding trial before leaving the hospital took part. The main goal was to …

This study tested several non-drug methods—like a textured plastic device called ShotBlocker, a vibrating ice pack (Buzzy), and a skin-tapping technique—to reduce pain from injections in children aged 4 to 6. 120 kids in a pediatric emergency department took part. The goal was to…

This pilot study tested whether manual lymphatic drainage, a gentle massage technique, is safe and feasible for patients recovering from septic shock. Researchers enrolled 24 adults in the ICU and compared those who received the massage plus usual care to those who received usual…

This study tested whether photodynamic therapy (PDT) — a light-activated disinfection method — can reduce pain after root canal treatment. 95 adults with infected back teeth received either standard cleaning or PDT-enhanced cleaning. Researchers measured pain levels and painkille…

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This pilot study tested whether kinesio taping, applied weekly for four weeks, can improve skin structure and reduce stage II cellulite in women aged 18-45 with normal BMI. Researchers compared a group receiving the tape on thighs and buttocks to a no-treatment control group. The…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study tested whether three new diagnostic tools could help doctors pick the best antibiotic faster for ICU patients with Gram-negative bloodstream infections. Researchers compared standard lab methods to the new tests in 100 patients. The goal was to see if more patients got…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

Sepsis and septic shock cause organ failure and death, and doctors need simple ways to flag the patients most at risk. Researchers at Benha University Hospital followed 60 adults with sepsis or septic shock in a surgical intensive care unit for 28 days. They compared two ratios c…

Prosthetic joint infections are rare but serious, often causing long hospital stays and lasting disability. Researchers at a French hospital are asking adults with these infections to fill out standard quality-of-life questionnaires during their regular follow-up visits. The stud…

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This study looks back at records of over 1,000 new hospital workers in Nice, France, who were tested for latent (hidden) tuberculosis infection as part of their hiring process. The goal is to see how many test positive, what factors increase the risk, and whether the screening le…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) affects the accuracy of a stool DNA test for H. pylori, a stomach bacteria. Researchers will test 25 adults who need PPIs, first while on the drug and then after stopping it for 4 week…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients …

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This completed Phase 3 study measured how high doses of the tuberculosis drugs rifapentine and moxifloxacin move through the body in 53 adults with TB. Participants gave multiple blood samples to track drug levels. The goal was to understand the best doses to kill TB bacteria whi…

This study follows 140 adults who have been treated for uncomplicated chlamydia or gonorrhea infections. Participants will have weekly swabs or urine tests to check when the bacteria's genetic material (RNA) disappears from the body, up to 4 weeks after starting treatment. The go…

This study will check if a new scoring system called SOFA-2 can better predict which ICU patients are likely to die within 30 days, compared to the current standard. Researchers will also measure how common sepsis and septic shock are in Turkish intensive care units. About 2,500 …

This study compares two strategies for finding undiagnosed tuberculosis (TB) in peri-urban Uganda. One strategy sets up screening at a large health clinic, while the other sends mobile screening teams into local hotspots where TB is thought to be most common. Researchers will tra…

This pilot study aims to test the feasibility of creating a large-scale cohort of tuberculosis (TB) patients in northern Paris, an area with high TB rates. Researchers will collect blood samples and clinical data from 30 participants over the course of their treatment to understa…

This study looks at patients receiving high-dose intravenous amoxicillin for serious bacterial infections. Researchers will measure drug levels in the blood during the first week to see how much they vary between patients and within the same patient. They will also check for side…

This study surveys senior managers at companies in Zambia with silica dust exposure to assess their knowledge, attitudes, and practices regarding tuberculosis. Since these leaders shape workplace policies, their understanding is key to protecting workers. The findings could highl…

This study looks at whether people who had leptospirosis, a bacterial infection spread by animals, may have health problems that last for years after the initial illness. Researchers in Reunion will follow about 200 patients who were previously hospitalized with the disease, chec…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This trial tests whether actively searching for leprosy cases in communities finds more people with the disease than waiting for them to come to clinics. Researchers will raise awareness, train healthcare workers, and use questionnaires and rapid tests in high-risk areas. About 1…

Septic shock is a life-threatening condition where infection leads to dangerously low blood pressure. Many patients also develop disseminated intravascular coagulation (DIC), a disorder that causes abnormal blood clotting throughout the body. This study will follow 60 adults in t…

This observational study aims to measure tetanus antibody levels in healthy adults living in Beijing, China. Researchers will analyze how antibody protection varies across different age groups and whether vaccination history predicts current immunity. Participants provide a singl…

This study looks at whether measuring oxygen and carbon dioxide differences in the blood can help predict which sepsis patients in the ICU are at highest risk of dying within 28 days. Researchers will track these levels in 88 intubated patients with sepsis who have a central veno…

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study looks at whether certain genetic variations (in COMT, MAOA, and SLC6A4) influence how well a standard dental numbing injection works for people with a painful tooth condition called irreversible pulpitis. Participants received a numbing shot and had their pain levels m…

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This completed pilot study tested whether two biomarkers (renin and DPP3) can predict how well patients with septic shock respond to angiotensin II, a drug that raises blood pressure. Forty adults with persistent low blood pressure despite standard treatment were randomly assigne…

This study looks at how drug-resistant bacteria, specifically ESBL-producing E. coli, are passed from mothers to their newborns during vaginal birth or scheduled C-sections. Researchers will test stool samples from 200 healthy mothers and their babies at a Chicago hospital to see…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study examined 750 emergency patients with joint pain to find out which germs cause septic arthritis. Researchers compared standard lab cultures with a new PCR test to see which works better. The goal is to help doctors diagnose joint infections more quickly and accurately.

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This completed study monitored 1560 adults hospitalized with invasive pneumococcal infections (excluding meningitis) across France. Researchers collected information on infection severity, risk factors, and bacterial serotypes to understand how these infections occur and how vacc…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study looked at 526 adults with sepsis who had normal blood pressure to see if a simple measure called the diastolic shock index (DSI) and a blood test for lactate could predict which patients would need medication to support their blood pressure within 6 hours. Researchers …

This completed study reviewed medical records of 203 adults hospitalized with Haemophilus influenzae pneumonia across 13 hospitals. Researchers aimed to find factors linked to early relapse (within 90 days) and severe outcomes like intensive care or death. By analyzing patient da…

This completed study looked at antibiotic resistance in bacteria causing urinary tract infections (UTIs) in Uganda. Researchers compared resistance patterns in patients who sought care at community drug shops versus hospitals. By studying 890 participants, they aim to understand …

This study looked at 58 full-term newborns with suspected early-onset sepsis to find early clinical signs that could help doctors tell if a bacterial infection is present. Researchers reviewed medical records from 2013 at a single hospital. The goal was to improve diagnosis and a…

This study tested whether a specific ultrasound-based algorithm could help doctors better manage fluids in patients with septic shock. The trial involved 136 intensive care patients and compared the algorithm to standard care over the first 4 days. The goal was to see if the algo…

This study looked at whether measuring hepcidin, a hormone that controls iron levels, in the blood of 114 patients with severe sepsis or septic shock could predict who would die within 28 days. Researchers also tracked deaths at 90 days and infections acquired in the hospital. Th…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This large study in rural Ethiopia looked at whether providing clean water, sanitation, and face-washing education can reduce trachoma infections in communities that have already received many rounds of antibiotics. Over 47,000 people from 40 communities took part. The goal is to…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked at 36 adults with painful tooth nerve inflammation (irreversible pulpitis) to see if biological markers in gum fluid match symptoms. Researchers collected gum fluid samples before and after root canal treatment and measured pain levels. The goal was to find a li…

This study looked at a new lab test called Antibiofilmogramme for people with diabetic foot infections caused by Staph bacteria. The goal was to see if the test could help doctors choose antibiotics that work better. 33 adults took part, and the study did not change their regular…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at 60 intensive care patients with septic shock to see if their intestines become leaky, allowing bacteria to enter the blood. Researchers measured specific markers in the blood over a week to track gut damage and changes in gut bacteria. The goal was to better …

This study tested whether bringing a portable TB test (Gene Xpert) directly to people in crowded communities helps find and treat more TB cases than the usual method of waiting for people to visit a clinic. Over 3,500 adults in South Africa took part. The goal was to see if this …

This study looked at whether using a portable ultrasound machine at the patient's bedside (called POCUS) helps doctors better treat people with septic shock in the intensive care unit. Researchers compared two groups of patients: one treated before POCUS was widely used and one a…

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This completed study monitored over 14,000 hospital patients for multidrug-resistant organisms (MDROs) by taking rectal swabs and tracking bloodstream infections. Researchers analyzed the bacteria's genetics and how they resist antibiotics, aiming to understand how resistance eme…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether giving antibiotics early to extremely low birthweight babies (born before 31 weeks) might cause more harm than good. Researchers compared babies who got standard antibiotics to those who got a placebo. The goal was to see if early antibiotics increase…

This study looked at whether eating fermented dairy products with three types of Bifidobacterium (with or without prebiotic fibers) for 28 days changes the variety of gut bacteria in healthy people aged 45 to 60. 182 participants ate either a test yogurt or a regular yogurt. The …

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This study tested whether a rapid test called Unyvero could help doctors choose the right antibiotic sooner for patients with pneumonia who are on breathing machines in the ICU. The test looks for bacteria and their resistance genes in just a few hours, compared to standard lab c…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

Cellulitis is a painful skin infection that often requires antibiotics, but the ideal treatment length is unknown. This study followed 230 adults hospitalized with cellulitis to identify factors that predict a good recovery, such as medical history and early response to treatment…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study examined whether giving ICU patients the same antibiotic they had before, versus a different one, affects the development of drug-resistant bacteria. Researchers looked at 197 adults with Gram-negative infections. The goal was to understand how antibiotic choice impact…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at two different ways of giving the antibiotic cloxacillin to treat bone and joint infections caused by Staphylococcus aureus bacteria. Twelve patients received the drug both as a steady drip (continuous infusion) and as short doses (intermittent infusion) to se…

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek sw…

This study looked at 1,145 children under 18 who were hospitalized in France for mycoplasma infections between June and November 2023. Researchers collected medical data to better understand the infection and improve hospital care. The goal was to describe the infection's feature…

This study looked at 440 ICU patients with septic shock to see how their heart's pumping and relaxation abilities affected survival. Researchers measured heart function using ultrasound and tracked fluid balance. The goal was to better understand which heart problems are linked t…

This completed early-phase study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious heart disease. Researchers safely exposed 40 healthy adults aged 18-40 to a specific strain of Strep A under controlled conditions. The goal was to see h…

This study looked at 197 ICU patients with bloodstream infections caused by carbapenem-resistant bacteria (superbugs). Researchers used machine learning to analyze patient data and predict which patients were at higher risk of dying. The goal is to create a tool that helps doctor…

This study aimed to create a smart surveillance strategy for carbapenem-resistant Pseudomonas aeruginosa (CRPA), a superbug that causes hard-to-treat infections in hospitals. Researchers collected samples from over 2,100 healthy people, patients, and hospital environments in the …

This study looked at 80 adults with septic shock to see if raising blood pressure from 65 mmHg to 85 mmHg improves kidney function. Researchers used ultrasound to measure kidney blood flow and tracked changes in kidney injury stages. The goal was to find out if a higher blood pre…

This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quic…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study looked at whether measuring immature platelets in the blood can help predict how septic shock patients will fare. Researchers followed 196 intensive care patients and checked if the immature platelet fraction at admission was linked to death or organ failure at 28 days…

This completed study looked at the safety of the VacPertagen whooping cough vaccine in over 5,400 people in Thailand, including pregnant women and their newborns. Healthcare workers reported any side effects after vaccination using standard forms. The goal was to catch any unexpe…

This study looked at whether giving a concentrated protein fluid called albumin, along with standard fluids, is possible in patients with septic shock (a life-threatening infection causing very low blood pressure). 47 adults took part to see if doctors could recruit enough patien…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at 103 adults with septic shock to see if a protein called VEGF-A is linked to how much extra fluid their bodies hold. Septic shock causes blood vessels to leak, leading to dangerous fluid buildup. Researchers measured VEGF-A levels and fluid balance to better u…

This study observed how fluids are given to nearly 5,000 critically ill patients in intensive care units (ICUs) worldwide. The goal was to describe current practices for fluid challenges (boluses) and maintenance fluids, and to see if different approaches are linked to patient ou…

This completed study looked at 52 adults with septic shock to see if a protein called PTP1B and gut barrier changes are linked to muscle loss. Researchers took blood samples and used ultrasound to measure muscle. The goal was to gather knowledge, not to test a treatment.

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this g…

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…

This study looked at 688 adults hospitalized with pneumonia in 11 hospitals in Colombia to find out how many cases were caused by pneumococcal bacteria. Researchers also identified which bacterial strains were most common and whether current vaccines cover them. The goal is to he…

This study tested whether giving a personalized dose of the antibiotic vancomycin to critically ill children in the ICU leads to better results than the standard approach. Researchers enrolled 314 children and compared how many reached the target drug level in their blood. The go…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This completed study looked at 200 women and their infants to understand how the whooping cough vaccine given during pregnancy affects the baby's immune protection. Researchers measured antibody levels in mothers and in umbilical cord blood at birth, as well as in infants after t…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This early-stage study tested a single dose of the antibiotic TQD3524 in 48 people with varying degrees of kidney function. The goal was to see how the drug moves through the body and is removed, especially by the kidneys, and to check for any safety issues. The study did not aim…

This completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study collected stool samples from 110 healthy adults aged 18-60 to help Danone advance its research on digestive health. Participants had to have regular bowel movements and be in good health. No treatment or medication was given; the goal was simply to gather enough usable…

This study looked at 300 people to see if a common stomach infection, H. pylori, is linked to unhealthy blood fat levels that can lead to heart disease. Researchers measured triglycerides and 'good' cholesterol to calculate a heart risk score. The goal is to understand if treatin…

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This study looked at the fluid between cells (interstitial fluid) in 26 intensive care patients with septic or non-septic shock. Researchers aimed to understand how this fluid changes during severe infections, which could help explain why swelling occurs and how to better manage …

This study examined tissue samples from 50 patients with staphylococcal bone and joint infections to see if bacteria can hide inside human cells. Researchers used special staining to detect intracellular staphylococci and identify which cell types they occupy. The goal was to bet…

This study looked at how the immune system responds to Clostridium difficile infection in hospitalized patients. Researchers took blood samples every two days to measure immune markers. The goal was to find out why some patients have repeat infections. The study involved 56 parti…

This completed study looked at how the immune system is weakened after septic shock, severe trauma, burns, or major surgery. Researchers took blood samples from 552 patients and healthy volunteers to measure immune function. The goal was to find better ways to predict and manage …

This early-stage trial tested the safety and drug interactions of an experimental oral antibiotic combination (QPX7831 plus ceftibuten) in 53 healthy adults. The goal was to see how the body processes the drugs and whether they cause side effects. Results will help decide safe do…

This study looked at how platelets (small blood cells that help with clotting) become activated in people with septic shock, a life-threatening infection that causes organ failure. Researchers measured specific markers on platelets and platelet-white blood cell clumps in 27 patie…

This study tested whether carefully limiting fluids given for non-emergency reasons (like nutrition or drug dilution) could reduce fluid overload in intensive care patients with septic shock. 50 patients were randomly assigned to either the standard approach or a restrictive flui…

This completed Phase 4 study looked at how the body processes echinocandin antifungal drugs (caspofungin or micafungin) in 24 adults with septic shock caused by peritonitis. Researchers measured drug levels in the blood to understand clearance, distribution, and concentration. Th…

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured a…

This study tested a handheld microscope to look at tiny blood vessels in 68 adults with sepsis or septic shock. The goal was to understand how these vessels break down during severe infection. The findings may help doctors design better treatments in the future.

This study looked at whether a clinical pharmacist could help increase pneumococcal vaccination rates in patients at high risk for infection when they leave the hospital. Researchers tracked how many vaccine prescriptions were given to 167 at-risk adults. The goal was to see if t…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study looked at 40 people with tooth inflammation (reversible or irreversible pulpitis) to see if certain immune markers in the blood (IL-8 and IL-10) could predict how well a tooth-saving treatment (vital pulp therapy) works. Participants received the therapy, and researche…

This study looked at 50 adults with septic shock to see how a sensitive heart ultrasound technique, called strain echocardiography, can track heart function changes. The goal was to understand if these measurements can help predict patient outcomes. The research did not test a tr…

This study tested two ways of giving anesthesia gas (sevoflurane) during kidney stone surgery. One method used a very low gas flow (minimal-flow), the other a slightly higher flow (low-flow). In 62 adults, the minimal-flow approach used less anesthesia drug while keeping patients…

This study looked at whether children with severe infectious shock develop immune suppression, similar to what is seen in adults. Researchers measured immune markers in 105 children admitted to intensive care and compared them to healthy children having surgery. The goal was to u…

This study tested whether having a study team call doctors with a checklist could improve how they manage patients with Staphylococcus aureus bloodstream infections. The calls reminded doctors of key steps like follow-up blood cultures, proper antibiotics, and imaging tests. The …

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This study tested a new scoring system that uses routine blood tests to predict the risk of death within one month for patients in intensive care with septic shock. Researchers looked at 780 patients to see how well the score works. The goal is to help doctors make faster, better…

This completed study tracked 581 hospitalized children aged 1-16 to see how antibiotic treatment affects the development of MRSA in the nose. Researchers compared children who received antibiotics to those who did not. The goal is to understand how antibiotic use drives antimicro…

This study looked at 145 patients with septic shock to see if the time when doctors check if a fluid bolus worked changes the results. Patients received 500 ml of fluid over 10 minutes. The study found that some patients who seemed to respond right away were no longer responding …

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This completed study looked at 209 patients with bacterial endocarditis, a serious heart valve infection, to understand how common anemia is and what causes it. Researchers measured blood markers for inflammation and anemia from diagnosis up to 6 months after hospital discharge. …

This study looked at two ways to guide fluid treatment in 60 emergency department patients with septic shock: using ultrasound or a noninvasive heart monitor. Both methods aim to give the right amount of fluids to improve blood pressure and organ function. Researchers tracked sur…

This study looked at how the COVID-19 pandemic and related measures like lockdowns and mask-wearing affected severe Group A Strep infections in children in Paris. Researchers reviewed medical records of 269 children under 18 admitted to a Paris hospital between 2018 and 2023. The…

This study looks at whether a listeria infection around the time of birth can lead to long-term thinking or behavior problems in children. Researchers will compare 53 children who had the infection with a control group using standard tests. The goal is to understand the role of t…

This study looked back at medical records of 1,730 adults with H. pylori infection who received bismuth-containing quadruple therapy as their first treatment. Researchers compared how well different drug combinations worked and what side effects occurred. The goal was to identify…

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis. Researchers compared these cells between patients and healthy donors, and also examined how chronic infection, CFTR modulator drugs, and lung flare-ups affect neutrophil behavior. Th…

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …

This completed study looked at how group B streptococcus (GBS) bacteria colonize the digestive tract of newborns. Researchers followed nearly 950 mothers and their babies, taking samples from the mother and umbilical cord at birth. The goal was to see if a specific, more dangerou…