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Antibiotic drip showdown: continuous vs. intermittent for bone infections

NCT ID NCT03246360

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two different ways of giving the antibiotic cloxacillin to treat bone and joint infections caused by Staphylococcus aureus bacteria. Twelve patients received the drug both as a steady drip (continuous infusion) and as short doses (intermittent infusion) to see if the amount of drug in the blood was similar. The goal was to find out if one method works as well as the other, not to test a new cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Nov 2017

Finished

Sep 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Staphylococcus aureus sensitive to methicillin and to be treated with cloxacillin by injectable antibiotic monotherapy For patients with Osteo-articular infection on material * Presence of a fistula in contact with the prosthesis or implant. * Pus in the joint or in contact with the prosthesis or implant * Presence of at least 1 positive sample (1 sampling by articular puncture or 1 peroperative sampling or by blood culture) * A histological analysis of the peri-prosthetic osteo-articular tissue which is the object of acute inflammation is a strong argument in favor of an Osteo-articular infection on material For spondylodiscitis * Culture of a disco-vertebral biopsy puncture to isolate a methicillin sensitive S. aureus * Positive haemocultures for S. aureus sensitive to methicillin with imaging examination (CT or MRI of the spine) showing images of spondylodiscitis For primitive arthritis : * Culture of a positive methicillin-sensitive S. aureus articular fluid puncture * Cultivation of a methicillin-sensitive S. aureus-positive surgical joint lavage fluid For osteitis the diagnosis is based on the following criterion: \*Culture of surgical specimens from a focal zone of methicillin-sensitive S. aureus-positive osteitis Exclusion Criteria: * Allergy to betalactamines * Taking penicillin M within 36 hours before inclusion Renal function impaired with a glomerular filtration rate measured by MDRD formula of less than 30 ml / min * Patient with renal function expected to change within 6 days of inclusion * Hepatocellular insufficiency, whatever the degree -\*Methotrexate intake * Polytransfused (more than 2 CGR) in the previous week * Patients requiring resuscitation

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Conditions

The condition(s) this trial relates to.

Infections infectious disease methicillin-susceptible staphylococcus aureus infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cloxacillin treatment Infection Methicillin susceptible staphylococcus aureus infection

Contacts and locations

Locations

  • CHU de Nice

    Nice, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.