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Massive ICU study questions routine acid-blocker use

NCT ID NCT02467621

Completed Knowledge-focused Sponsor: Dr. Morten Hylander Møller Source: ClinicalTrials.gov ↗

First seen May 22, 2026 · Last updated May 22, 2026

Summary

This study looked at whether giving a common acid-reducing drug (a proton pump inhibitor) to adults in the intensive care unit (ICU) helps prevent stress ulcers and stomach bleeding, and whether it affects survival. Over 3,300 critically ill patients with risk factors like shock or mechanical ventilation took part. The goal was to find out the true benefits and harms of this routine practice.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dept. of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet

    Copenhagen, 2100, Denmark

  • Dept. of Intensive Care, Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Dept. of Intensive Care, Akershus University Hospital

    Lørenskog, 1478, Norway

  • Dept. of Intensive Care, Basel University Hospital

    Basel, 4056, Switzerland

  • Dept. of Intensive Care, Bergen University Hospital

    Bergen, 5021, Norway

  • Dept. of Intensive Care, Bern University Hospital

    Bern, 3010, Switzerland

  • Dept. of Intensive Care, Bispebjerg Hospital

    Copenhagen, 2400, Denmark

  • Dept. of Intensive Care, Copenhagen University Hospital Herlev

    Herlev, 2730, Denmark

  • Dept. of Intensive Care, Heerlen Hospital

    Heerlen, 6419, Netherlands

  • Dept. of Intensive Care, Helsinki University Hospital

    Helsinki, 00120, Finland

  • Dept. of Intensive Care, Herning Hospital

    Herning, 7400, Denmark

  • Dept. of Intensive Care, Hillerød Hospital

    Hillerød, 3400, Denmark

  • Dept. of Intensive Care, Hjørring Hospital

    Hjørring, 9800, Denmark

  • Dept. of Intensive Care, Holbæk Hospital

    Holbæk, 4300, Denmark

  • Dept. of Intensive Care, Holstebro Hospital

    Holstebro, 7500, Denmark

  • Dept. of Intensive Care, Kuopio University Hospital

    Kuopio, 70029, Finland

  • Dept. of Intensive Care, Køge University Hospital

    Køge, 4600, Denmark

  • Dept. of Intensive Care, Nykøbing Falster Sygehus

    Nykøbing Falster, 4800, Denmark

  • Dept. of Intensive Care, Oslo University Hospital

    Oslo, 0450, Norway

  • Dept. of Intensive Care, Oulu University Hospital

    Oulu, 90210, Finland

  • Dept. of Intensive Care, Randers Hospital

    Randers, 8930, Denmark

  • Dept. of Intensive Care, Roskilde Hospital

    Roskilde, 4000, Denmark

  • Dept. of Intensive Care, Slagelse Hospital

    Slagelse, 4200, Denmark

  • Dept. of Intensive Care, Stavanger University Hospital

    Stavanger, 4011, Norway

  • Dept. of Intensive Care, Tampere University Hospital

    Tampere, 33520, Finland

  • Dept. of Intensive Care, Turku University Hospital

    Turku, 20521, Finland

  • Dept. of Intensive Care, University Hospital of Wales

    Cardiff, United Kingdom

  • Dept. of Intensive Care, University Medical Center Groningen

    Groningen, 9713, Netherlands

  • Dept. of Intensive Care, Vejle Hospital

    Vejle, 7100, Denmark

  • Dept. of Intensive Care, Viborg Hospital

    Viborg, 8800, Denmark

  • Dept. of Intensive Care, Århus University Hospital Nørrebrogade

    Aarhus, 8000, Denmark

  • Dept. of Intensive Care, Århus University Hospital Skejby

    Aarhus, 8000, Denmark

  • Dept. of Neurointensive Care, Copenhagen University Hospital Rigshospitalet

    Copenhagen, 2100, Denmark

Conditions

Explore the condition pages connected to this study.

GASTROINTESTINAL BLEEDING STRESS ULCERS