Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain surgery infection fighter: vancomycin powder put to the test

NCT ID NCT02284126

Disease control Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying vancomycin powder directly to the surgical wound during brain surgery can reduce infections. Over 1,100 adults having neurosurgery were randomly assigned to receive either the topical vancomycin or standard care. The main goal was to see if the treatment lowered the rate of surgical site infections within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vancomycin (topical powder or paste)
What this could lead to
If it works, this could provide a simple way to lower infection risk after brain surgery, reducing complications and hospital stays.
What could go wrong
This is a single-blinded trial; results may not apply to all surgeries. Vancomycin resistance or side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,103 people

The number who actually took part.

Start date

Oct 2014

Finished

Nov 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (18+) neurosurgical procedure (ie.Craniotomy, Craniectomy, and Cranioplasty) Exclusion Criteria: * Creatinine \> 1.50 mg/dL on admission * Vancomycin allergy (documented or self-reported) * Evidence of infection at or near the planned surgical site * No planned dural or dural-substitute closure * Spinal instrumentation (topical vancomycin is already standard of care) * No surface area to apply:Carotid endarterectomy, MRI-guided laser ablation * Trans-sphenoidal approach * Acoustic neuroma resection * Surgeon preference for or against use in the given procedure

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Infection are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bacterial infectious disease central nervous system infectious disorder Infections infectious disease nervous system disorder Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection Nervous system diseases Surgery

Contacts and locations

Locations

  • Columbia University Medical Center

    New York, New York, 10032, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.