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New vaccine strategy aims to shield spleenless adults from deadly infections

NCT ID NCT02052154

First seen Nov 20, 2025 · Last updated May 23, 2026 · Updated 20 times

Summary

This study tested a two-step pneumococcal vaccine approach in 70 adults who had their spleen removed. Participants received one dose of a conjugate vaccine followed by a second dose of a polysaccharide vaccine two months later. The goal was to see if this combination improved immune response against 9 common pneumococcal bacteria types that can cause serious infections. Results were measured by antibody levels one month after the second shot.

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Contacts and locations

Locations

  • Service des Maladies Infectieuses et Tropicales - Centre d'Infectiologie Necker-Pasteur, IHU Imagine - Hôpital Necker-Enfants

    Paris, 75015, France

Conditions

Explore the condition pages connected to this study.