New vaccine strategy aims to shield spleenless adults from deadly infections

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years and ≤ 75 years * Splenectomized since at least 2 weeks, with Howell-Jolly bodies on a blood smear and ultrasonographic confirmation * No immunosppressived conditions : mainly trauma , idiopathic thrombocytopathic purpura or autoimmune hemolytic anemia, with no active treatment * Available for 37 months of follow-up starting from the screening visit * Contraception that the investigator judges effective for the first 2 months of the trial, with a negative pregnancy test * Women not planning to become pregnant in the 6 months following inclusion (M0) * Signed informed consent Exclusion Criteria: * Pregnancy or planned pregnancy in the 2 months following inclusion (M0) * Pathology or conditions which modify immune response (excluding splenectomy) : HIV infection, immunosuppressive therapy ongoing or in 6 months before inclusion (M0), including corticosteroids \> 10 mg daily, topic inhaled or dermic corticoid treatments are allowed, hematopoietic stem cell allo / autograft, primary immune deficiency, nephrotic syndrome, sickle cell disease, evolutive neoplasia * History of anaphylactic reaction following vaccination * Known allergy to any of the ingredients of the vaccines: aluminium phosphate, phenol, Corynebacterium diphtheriae CRM-197 protein * Previous vaccination with 7-valent or 13-valent pneumococcal conjugate vaccine (in the 5 last years) * Previous vaccination with the pneumococcal polysaccharidic vaccine in the 3 years before inclusion (M0) * Other vaccination in the month before inclusion (M0) * Polyvalent immunoglobulin infusion in the 3 months before inclusion (M0) or during the planned duration of the study * Anticoagulant treatment current or stopped less than 7 days before inclusion (M0); or clotting disorder contra-indicating intramuscular injection * Participation to an other vaccine study in the 28 days before inclusion till the end of study * Not covered by national health insurance (beneficiary or assignee)