Bacterial infectious disease

This trial compares different surgical and antibiotic approaches to treat infections in artificial hip and knee joints. It tests whether cleaning the joint while keeping the implant in place (DAIR) or replacing the joint entirely leads to better cure rates. It also examines wheth…

This trial is testing a new vaccine called rBCG-N-RSV, which is based on the BCG vaccine (used for tuberculosis) but modified to also target respiratory syncytial virus (RSV). The study involves 200 adults over 60 years old, who will receive either this new vaccine or the standar…

This study tests a new pneumococcal vaccine in about 2400 healthy infants starting at 2 months old. The goal is to see if the new vaccine is as safe as the current vaccine, Prevnar 20, and if it can protect against more types of bacteria that cause pneumonia, meningitis, and ear …

This phase 3 study tests an investigational meningococcal conjugate vaccine in healthy infants and toddlers aged 2 to 23 months in China. The vaccine targets four serogroups of meningococcal bacteria (A, C, W, Y) that can cause meningitis and bloodstream infections. Researchers c…

This study tests whether a vaccine can prevent C. difficile infection in adults 65 and older. About 32,000 participants will receive either the vaccine or a placebo shot. The study will track infections and side effects over up to three and a half years.

This study tests a new pneumococcal vaccine in healthy infants to see if it is safe and works better than the current vaccine. About 3,230 babies will receive either the new vaccine or the existing one at routine checkups. Researchers will compare side effects and immune response…

This study tests an experimental vaccine called V132 in healthy adults aged 50 and older. The goal is to see how safe it is and how well it triggers an immune response compared to existing pneumococcal vaccines. Participants will receive one of several formulations of V132 or a c…

This study tests a new pneumococcal vaccine (PG4) in healthy children aged 15 months to 18 years. About 1,200 participants will receive either the new vaccine or the current Prevnar 20. Researchers will compare safety and immune response over 6 months. The goal is to see if the n…

This study tests a vaccine given to pregnant women to see if it can protect their babies from group B streptococcus (GBS) infection, a serious illness in newborns. Healthy pregnant women aged 49 or younger, between 24 and 36 weeks of pregnancy, can join. Participants receive one …

This study tests whether two different pneumococcal vaccines can create antibodies that kill newly discovered types of pneumonia bacteria. Researchers will give healthy adults one of the vaccines and measure how well their immune system fights these bacteria. The goal is to see i…

This first-in-human trial tests an experimental vaccine called LTB-NG6, designed to protect against gonorrhea. The study will enroll healthy adults aged 18-50 to evaluate the vaccine's safety and its ability to trigger an immune response. Participants will receive either the vacc…

This first-in-human trial tests a new vaccine designed to protect against Group A Streptococcus (Strep A), a bacteria that can cause sore throats, skin infections, and more serious illnesses. Healthy adults aged 18 to 25 will receive one of two vaccine formulations, each with a d…

This trial evaluates an experimental vaccine called 20vPnC, designed to protect against 20 types of pneumococcal bacteria. Healthy infants aged 42 to 98 days will receive either 20vPnC or the approved 13vPnC vaccine at 2, 4, 6, and 12-15 months. The study aims to compare safety a…

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if…

This study is testing a new tuberculosis vaccine called MTBVAC in 276 adolescents and adults in South Africa, some of whom have HIV. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants will receive either MTBVAC or the standard BCG vaccin…

This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the proce…

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths …

This study tests whether using a chat-based mobile app (Zalo) can help people follow through with recommended tests after an abnormal chest X-ray read by AI. About 2,692 adults in Vietnam at risk for lung cancer or TB will be randomly assigned to receive either standard results o…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if it works as well as the current 18+ month regimen. About 55 adults in France will receive the shorter treatment, and their outcomes will be compa…

Researchers are following 100 people newly diagnosed with Mycobacterium avium complex pulmonary disease (MAC-PD) who need standard three-drug antibiotic treatment. The study measures how many patients clear the infection after six months, how their bacterial load changes, and how…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-E…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transpl…

This study tests new combinations of drugs for adults with lung tuberculosis (TB). The goal is to see if these new regimens work faster and are safer than the current standard treatment. About 315 participants will receive either an experimental drug combo or the usual care for 8…

This study tests whether oral antibiotics (linezolid or amoxicillin) can effectively treat newborns at risk of congenital syphilis, compared to a standard penicillin shot. The goal is to find a safe, outpatient-friendly option that avoids long hospital stays. The trial involves 9…

This phase 3 trial will test how well two different triple therapies—one using a standard acid reducer (proton pump inhibitor) and one using a newer drug (vonoprazan)—work to eliminate H. pylori infection. It will also see if adding zinc improves results. The study plans to enrol…

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study tests a newer acid-blocking drug (vonoprazan) against a standard one, each combined with vitamin D or probiotics, to treat H. pylori infection. About 66 adults with confirmed H. pylori will receive one of three treatments for two weeks. The goal is to see which combina…

This trial tests whether a special filter called oXiris, used during continuous blood purification, can lower endotoxin levels in adults with septic shock and acute kidney injury. Septic shock is a life-threatening condition where infection causes severe organ failure. The filter…

This study tests whether adding hyperbaric oxygen treatment (breathing pure oxygen in a pressurized chamber) to standard care can lower the death rate in people with severe, fast-spreading soft-tissue infections. About 1,480 adults with surgically confirmed infection will be rand…

This study compares different antibiotic strategies for people hospitalized with Gram-negative bloodstream infections. The goal is to find which approach leads to better outcomes, like survival and fewer complications, while also reducing the risk of antibiotic resistance. About …

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This early study is testing whether giving a transplant of healthy gut bacteria (called IMT) through a feeding tube is safe and doable in 40 adults who have had part of their colon removed due to diverticulitis or sigmoid colon cancer. Participants get the transplant a couple of …

This study tests an experimental drug called dovramilast in 45 adults with moderate to severe leprosy type 2 reaction, a painful skin condition. Participants receive either dovramilast (100 mg or 150 mg) or standard treatments like prednisolone or thalidomide. The goal is to see …

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This pilot study tests whether giving angiotensin II early in the emergency department can help stabilize blood pressure in patients with septic shock. Twenty adults who need a standard drug called norepinephrine will receive angiotensin II as an add-on. The main goal is to see i…

This study tests whether a shorter treatment regimen (13-24 weeks) using a combination of drugs (bedaquiline, linezolid, pretomanid, and moxifloxacin) works as well as the standard longer treatment for people with a type of drug-resistant tuberculosis. About 400 adults with fluor…

This trial tests a new way to treat Helicobacter pylori, a common stomach bacteria linked to ulcers and cancer. Researchers compare a staged regimen that gradually increases the amoxicillin dose against a standard 14-day dual therapy. The study enrolls adults with chronic gastrit…

This study tests whether giving the drug vasopressin earlier or later during septic shock leads to better outcomes. Researchers will use a computer alert system to randomly assign 300 ICU patients to early or standard timing. The goal is to see if the timing can be reliably contr…

This trial tests whether capsules containing stool from healthy donors can treat recurrent Clostridium difficile colitis, a severe bowel infection that keeps coming back. Adults who have had three or more episodes in the past year may participate. Researchers give the capsules by…

This trial tests whether using calcium hypochlorite or sodium hypochlorite to clean the pulp wound during a partial pulpotomy can improve the success of saving painful, deeply decayed permanent molars. Adults aged 18-40 with symptomatic irreversible pulpitis will undergo the proc…

This study looks at whether using a combination of antibiotics is more effective than a single antibiotic for treating serious staph infections in the blood. About 2,096 adults with either methicillin-sensitive or methicillin-resistant staph will be randomly assigned to one group…

This pilot trial explores whether a non-invasive cardiac output monitor (NICOM) can help guide fluid resuscitation in emergency department patients with sepsis and low blood pressure. Participants receive standard care, and some also undergo a one-time NICOM assessment that inclu…

This trial investigates whether therapeutic plasma exchange — a procedure that filters the blood to remove harmful substances — can reduce deaths in critically ill children with severe sepsis or septic shock. Participants are randomly assigned to receive either standard sepsis ca…

This study tests whether a single surgery to replace an infected artificial knee works as well as the standard two-surgery approach. About 153 patients with a chronic knee infection will be randomly assigned to one of the two treatments. Researchers will track pain, function, and…

This study compares standard beta-lactam antibiotics alone versus beta-lactam plus levofloxacin in adults with streptococcal bacteremia (bacteria in the blood). 165 participants will be randomly assigned to receive either the combination or monotherapy. The goal is to see if addi…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This phase 2 trial is investigating how a combination of two antibiotics, cefepime and enmetazobactam, is processed by the body and whether it is safe and tolerable in children from birth to under 18 years old who are hospitalized with a complicated urinary tract infection (cUTI)…

This study tests whether reducing immunosuppressive drugs (along with giving a steroid) helps kidney transplant patients recover from septic shock or severe breathing failure in the ICU. About 212 adults whose transplant was at least 3 months ago will be randomly assigned to eith…

This study tests a new drug called AZD7760 in healthy volunteers and people with end-stage kidney disease who are on dialysis. The goal is to see if the drug is safe and how the body processes it. If it works, it could help prevent serious staph infections that often occur in dia…

This study investigates whether inhaling the antibiotic amikacin can better treat pneumonia caused by gram-negative bacteria in patients on veno-arterial ECMO (a heart-lung bypass machine). Standard antibiotics often fail in these patients, possibly because the bypass reduces blo…

This trial tests whether a simpler dental procedure called pulpotomy works as well as the standard pulpectomy for treating severe tooth decay in children's baby molars. Pulpotomy removes only the infected part of the pulp and seals it, while pulpectomy removes the entire pulp and…

This trial tests whether using a blood marker called procalcitonin (PCT) to guide antibiotic decisions can safely shorten treatment duration in children with bacterial infections in intensive care. About 296 children will be randomly assigned to either PCT-guided care or standard…

This trial is testing whether a 4-month treatment for drug-sensitive pulmonary tuberculosis works as well as the standard 6-month regimen. The study involves 270 adults with newly diagnosed TB. If the shorter course proves effective, it could make treatment easier to complete and…

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This trial investigates how a weekly TB prevention regimen (rifapentine and isoniazid) affects levels of the HIV drug dolutegravir in children living with HIV. Researchers will measure drug concentrations in the blood to see if the combination remains safe and effective. The stud…

This study tests whether a medicine called XEMBIFY, given every two weeks alongside standard care, can reduce serious bacterial infections in adults with certain blood cancers (chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin lymphoma) who also have low antibody lev…

This trial compares two oral antibiotics—trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin—to see which works better for children with invasive MRSA infections, such as bone, joint, or deep tissue infections. About 100 children aged 60 days to 18 years will take one of the …

This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as e…

This early-stage trial tests MP101, a mix of two viruses that attack bacteria (phages), in 18 adults with Pseudomonas aeruginosa pneumonia. Participants receive a single dose of MP101 or a placebo alongside standard antibiotics. The main goal is to check safety and how the body h…

This study tests whether a 2-month combination of four drugs can cure drug-susceptible tuberculosis in children under 10 as safely and effectively as the standard 4- to 6-month regimen. Researchers will enroll 860 children, including those with HIV, to compare the shorter treatme…

This study tests whether a digital health program—short videos and text message reminders—can help close contacts of tuberculosis patients start and complete preventive treatment. Researchers in South Ethiopia will enroll 304 people and compare those who get the digital intervent…

This trial compares a steam mask — a fabric mask with self-hydrating beads heated in a microwave — to the traditional warm compress (a towel soaked in warm water) for treating chalazion, a common eyelid lump, in children aged 5 to 16. Researchers will measure whether the steam ma…

This study compares two doses of the antibiotic ceftriaxone—500 mg versus 1000 mg—given as a single shot to treat uncomplicated gonorrhea. Researchers want to see if the lower dose works just as well, which could mean fewer side effects and less antibiotic use. The trial involves…

This trial investigates whether giving the protein albumin together with standard intravenous fluids during the first hours of treatment can reduce deaths in people with septic shock. About 2,400 adults arriving at emergency departments with septic shock will be randomly assigned…

This phase 1 study tests whether inhaling high doses of the antibiotic isoniazid is safe and tolerable for people with tuberculosis. Eight adults with known drug-sensitive TB will receive single inhaled doses of 200, 600, and 1200 mg, plus one intravenous dose for comparison. Res…

This registry study is following 200 adults with sepsis or septic shock who receive ARTICE® therapy in the ICU. Researchers are tracking organ function, survival, and complications to see how well the treatment works in everyday practice. The goal is to identify which patients be…

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorte…

This trial tests a special bone graft that releases the antibiotic tobramycin to treat infected knee replacements. The graft is placed during the first stage of revision surgery, with the goal of clearing the infection and promoting new bone growth. About 200 adults with infected…

This study tests whether adding the antibiotic linezolid to standard treatment improves outcomes for people with Staphylococcus aureus bloodstream infections. About 606 hospitalized adults will receive either linezolid or a placebo for five days. The goal is to see if the combina…

This study tests whether fecal microbiota transplantation (FMT) capsules, made from healthy donor stool, can prevent C. diff infection from coming back better than standard antibiotics. About 100 adults with a first or first-recurrent C. diff infection will get either antibiotics…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This trial tests whether using infection surveillance data to guide antibiotic selection can reduce antibiotic resistance in hospitalized cirrhosis patients with bacterial infections. About 198 adults with decompensated cirrhosis and a confirmed or suspected infection will be ran…

This study tests whether giving a combination of activated charcoal and polyethylene glycol (a laxative) can reduce the amount of toxic drugs absorbed in the gut for people with severe poisoning in intensive care. Two hundred adults on ventilators will be randomly assigned to get…

This study tests whether a peer-led education program helps adults with drug-susceptible tuberculosis complete treatment successfully. Researchers in southern Ethiopia will enroll 250 adults and provide structured education, counseling, and follow-up from trained peers. The goal …

This study tests two different drug combinations for pleural infection, a serious infection of the lung lining that often requires surgery. The standard treatment uses two drugs (alteplase and DNase) given through a chest tube. This trial compares that to a new combination using …

This study tests whether taking oral vancomycin while on other antibiotics can prevent a repeat Clostridioides difficile infection (CDI) in people who had one in the last 120 days. Researchers will compare vancomycin to a placebo in 300 adults. Participants take the study drug tw…

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study tests a combination of two antibiotics, aztreonam and avibactam, in newborns and infants up to 9 months old who have serious infections caused by gram-negative bacteria. The trial has two parts: one to see how a single dose moves through the body, and another to test m…

This study tests whether giving a personalized dose of Pentaglobin (an antibody treatment) after surgery helps people with severe abdominal infection (peritonitis) and sepsis recover better. Researchers will enroll 200 patients and track organ failure and survival. The goal is to…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This pilot study tests whether adding fludrocortisone (a steroid pill) to standard hydrocortisone treatment helps people with septic shock. Only 32 critically ill adults will take part. The main goal is not to see if the combo works, but to check if a larger, more definitive tria…

This study compares two pneumococcal vaccination strategies in 160 adults with lymphoma who have had chemotherapy. One group gets two vaccines (Prevenar 13 followed by Pneumovax 23), while the other gets a single newer vaccine (Prevenar 20). Researchers will measure immune respon…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study tests four approaches to help adults with drug-resistant tuberculosis and HIV stick to their treatments. Participants receive either standard care, counseling, phone reminders via a special pill bottle, or both counseling and reminders. The goal is to see which method …

This study is testing whether the BCG vaccine, originally developed for tuberculosis, can safely treat Mycobacterium avium complex (MAC) lung disease. Researchers will give 48 adults either a single BCG injection or a placebo and monitor them for side effects, immune responses, a…

This study tests whether giving children with a severe E. coli infection extra fluids through an IV can prevent kidney failure. About 1,040 children aged 9 months to 21 years will take part. The goal is to see if this simple approach reduces the need for dialysis or long-term kid…

This phase 3 trial compares a 5-day course of the antibiotic flucloxacillin to the standard 7-day course for adults with leg cellulitis. About 334 participants will receive either 5 days of active drug plus 2 days of placebo, or 7 days of active drug. The goal is to see if the sh…

This study tests whether adjusting the dose of the antibiotic linezolid based on regular blood tests can reduce harmful side effects in people being treated for multidrug-resistant tuberculosis (MDR-TB). The trial will enroll 150 patients in Guinea who are on a standard 6-month r…

This clinical trial is testing different combinations of antibiotics to find the best way to treat a lung infection caused by Mycobacterium abscessus, a bacteria that is hard to kill. About 300 adults and children with this infection will receive various drug regimens, including …

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests whether a new drug called quabodepistat can shorten treatment for drug-resistant tuberculosis (TB) from 6 months to 4 months. About 532 adults and teens with rifampicin-resistant or multidrug-resistant TB will be randomly assigned to receive either the new shorte…

This study tests whether regularly measuring linezolid levels in the blood can prevent dangerous side effects and keep people on their tuberculosis treatment. About 280 adults with rifampin-resistant TB will be randomly assigned to either standard care or dose adjustments based o…

This study tests a drug called epetraborole for people with a chronic lung infection caused by Mycobacterium abscessus. About 84 adults will take either a low or high dose of the drug or a placebo for 84 days. Researchers will check if symptoms improve and if the infection clears…

This massive international trial is testing several antibiotics and treatment strategies to find the best way to reduce deaths from Staphylococcus aureus bloodstream infections. About 8,000 hospitalized adults with a confirmed staph blood infection will be randomly assigned to di…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests whether a microbiome therapy—a capsule of healthy gut bacteria—can reduce drug-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to see if the treatme…

This study looks at 600 adults with infections caused by a hard-to-treat bacteria called Pseudomonas aeruginosa. Researchers will compare newer and older antibiotics to see which works best to cure the infection. The goal is to find the most effective treatment for these dangerou…

This study tests whether penicillin works better than the usual antibiotic cloxacillin for people with a Staph blood infection that is sensitive to penicillin. About 420 adults will be randomly assigned to one of the two treatments. The main goal is to see who survives 90 days wi…

This study tests whether taking capsules made from healthy donor stool (fecal microbiota transplantation, or FMT) can prevent another bout of C. diff infection in people who have had it come back at least twice. 76 adults will receive either active FMT capsules or placebo, and re…

This study tests whether giving the drug norepinephrine early and adjusting the dose quickly can improve survival in adults with septic shock. Researchers will compare this approach to standard care with a placebo. Six hundred participants will be monitored for 28 days to see if …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This study tests whether a 7-day combination of vonoprazan, high-dose amoxicillin, and bismuth can effectively eradicate H. pylori bacteria in the stomach. About 316 adults with a first-time H. pylori infection will be randomly assigned to either the 7-day triple therapy or a sta…

This pilot study tests whether a mild electrical pulse to the ear (vagus nerve stimulation) can reduce inflammation and improve heart rate balance in people with septic shock. 34 participants will be randomly assigned to receive either active stimulation or a sham (placebo) for 4…

This study looks at whether giving antibiotics to children with a certain type of Shigella infection (non-dysentery watery diarrhea) helps them recover faster and grow better. About 700 children in Bangladesh and Zambia will receive either azithromycin or a placebo. Researchers w…

This study tests whether an 8-week or 24-week pulmonary rehabilitation program (exercise and breathing training) helps people recover lung function after completing tuberculosis (TB) treatment. About 690 adults with confirmed TB will be randomly assigned to one of two rehab progr…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study looks at whether switching to the blood thinner dabigatran can improve outcomes for people with a serious staph bloodstream infection who are already taking other blood thinners. Researchers will compare those who switch to dabigatran with those who stay on their curre…

This study looks at whether switching from aspirin to clopidogrel (another blood thinner) can reduce heart complications in people with a serious staph bloodstream infection. About 300 adults already taking aspirin for heart disease will be randomly assigned to stay on aspirin or…

This study is testing whether a powerful antibiotic called piperacillin/tazobactam can be given as a continuous shot under the skin instead of through an IV line. About 240 adults with serious bacterial infections will be randomly assigned to receive the drug either subcutaneousl…

This study tests whether adding a special virus mixture (phage therapy) to standard antibiotics can improve outcomes for people with a serious heart valve infection called infective endocarditis. About 30 participants will receive either the phage therapy or a placebo alongside t…

This study compares two ways to treat Gram-negative bloodstream infections: staying on IV antibiotics versus switching to oral pills early. Researchers want to see if the oral option works just as well but causes fewer side effects. About 1,030 hospitalized adults will take part,…

This study is testing an antibiotic called Sulbactam-Durlobactam in hospitalized children from birth to under 18 years old who have or may have an Acinetobacter infection. The goal is to find the right dose and check that it is safe. About 48 children will receive the drug throug…

This study tests a new way to treat H. pylori, a bacteria that can cause stomach ulcers and cancer. During an endoscopy, doctors fill the stomach with a saltwater solution that is activated by argon plasma to kill the bacteria. The trial will compare two methods of making this so…

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This study tests whether people with asymptomatic tuberculosis (TB) can be treated effectively with a shorter course of standard antibiotics—17 weeks instead of the usual 6 months. Researchers will compare the shorter regimen to standard treatment in 426 participants in China. Th…

This study tests whether giving vasopressin early, along with norepinephrine, is better than waiting to use it as a rescue treatment for people with septic shock. About 2,800 critically ill adults will be randomly assigned to one of two strategies. The main goal is to see which a…

This pilot study is testing whether giving activated charcoal within 6 hours of swallowing a poisonous substance can prevent the poison from getting worse and shorten hospital stays. About 100 adults and children who have ingested a substance that charcoal can absorb will be rand…

This study tests whether adjusting the dose of the TB drug rifampin based on a simple urine test can improve treatment outcomes. Researchers will enroll 200 adults and children with active, drug-sensitive tuberculosis in Tanzania. The goal is to see if personalized dosing helps m…

This study tests whether a simpler way of dosing the antibiotic vancomycin (targeting a trough level of 10-15 mg/L) works as well as the more complex method (targeting AUC/MIC 400-600) for treating serious MRSA infections. About 700 adults with infections like bloodstream, lung, …

This study tests three different antibiotic combinations to treat a dangerous, drug-resistant bacteria called CRAB that causes infections in intensive care patients. Researchers will compare colistin combined with either fosfomycin, ampicillin/sulbactam, or eravacycline in 108 su…

This study tests whether a higher dose of the antibiotic rifampicin (1800 mg daily) is safe and works better than the standard dose for adults with pulmonary tuberculosis. About 164 participants will be randomly assigned to either the optimized or standard dose. Researchers will …

This study tests three different anti-ulcer medications (Dexlansoprazole, Lansoprazole, and Vonoprazan) combined with two antibiotics (Levofloxacin and Amoxicillin) to see which works best for eradicating H. pylori infection. About 942 adults in Pakistan with H. pylori will take …

This study looks at whether the antibiotic clindamycin works as well as other drugs for treating Streptococcus infections in artificial joints. Researchers will compare success rates in 260 adults who had surgery for this infection. The goal is to see if clindamycin can be a good…

This study is testing a special silver coating on hip implants to see if it can prevent infections after revision hip replacement surgery. The trial will enroll 268 adults who need a hip revision due to a chronic infection. Participants will receive either the coated implant or a…

This study compares two antibiotic treatments for acute kidney infection in children aged 1 month to 3 years. One group gets 3 days of IV antibiotics only, while the other gets 3 days IV followed by 7 days of oral antibiotics. The goal is to see if the shorter course works just a…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study tests different combinations of acid-blocking drugs (P-CABs) with bismuth and antibiotics to treat H. pylori, a stomach infection that can cause ulcers. About 1,730 adults aged 18-70 with confirmed H. pylori will receive one of several treatment regimens. Researchers w…

This study looks at whether it is safe to stop antibiotics early in adults with high-risk blood cancers or those who have had stem cell transplants or CAR T-cell therapy. Participants will be randomly assigned to stop antibiotics once their fever goes away or continue until their…

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care…

This phase 2 trial tests whether adding adalimumab (an arthritis drug) to standard tuberculosis meningitis treatment can reduce deaths in HIV-positive adults. About 130 participants in Brazil, Mozambique, and Zambia will receive adalimumab injections every two weeks for 10 weeks …

This study looks at 330 adults with a serious heart valve infection (prosthetic valve endocarditis) caused by S. aureus bacteria. It compares the standard approach of giving the antibiotic rifampin against not giving it, to see if skipping it is just as safe and effective. The go…

This study looks at whether using a combination of antibiotics is more effective than a single drug for treating Enterococcus faecalis bloodstream infections. Researchers will also analyze the gut bacteria of 510 adult patients to see how it affects treatment success. The goal is…

This phase 3 trial is testing three different ways to give the meningococcal B vaccine to adults who have had their spleen removed. People without a spleen are at higher risk for serious infections. The study will compare how well each vaccine schedule triggers the immune system …

This study tests two different 14-day treatments for Helicobacter pylori, a bacteria that can cause stomach ulcers. About 240 adults with confirmed infection will take either tegoprazan or vonoprazan, both combined with amoxicillin. The goal is to see if the newer tegoprazan comb…

This study tests whether adding an inhaled form of the antibiotic amikacin (ARIKAYCE) to standard treatment helps clear Mycobacterium xenopi from the lungs faster. About 190 adults with this rare, hard-to-treat lung infection will receive either standard care alone or standard ca…

This study looks at whether giving children with bone and joint infections antibiotics only by mouth works just as well as starting with IV antibiotics for a few days and then switching to pills. About 285 children aged 1 to 18 from hospitals in Australia and New Zealand will tak…

This study compares two antibiotics, clarithromycin and azithromycin, for treating MAC lung infections, a serious bacterial lung disease. About 424 adults with MAC infection will receive one of the two drugs alongside standard treatments. The goal is to see if azithromycin works …

This study tests whether giving the steroid hydrocortisone to children with septic shock can prevent new or worsening organ failure. About 500 children in intensive care will receive either hydrocortisone or a placebo for up to seven days. The goal is to see if this treatment imp…

This study tests whether replacing an infected heart device immediately after removal is as safe and effective as waiting for a later procedure. About 176 adults with device infections will be randomly assigned to either immediate or delayed reimplantation. The main goal is to se…

This study tests new drug combinations to treat pulmonary tuberculosis (TB) faster than the standard 24-week regimen. About 2500 adults with TB will receive one of several experimental combinations, including two new drugs (BTZ-043 and GSK3036656), for 8 to 16 weeks. Researchers …

This study is testing the safety of a drug called gallium nitrate in 40 adults with cystic fibrosis who have a difficult-to-treat lung infection called NTM. Participants will receive two 5-day cycles of the drug through an IV. The main goal is to see if the treatment is safe and …

This study tests whether adding a second antibiotic (fosfomycin) to the standard antibiotic (ceftazidime) helps people with severe gram-negative infections recover faster. About 100 hospitalized adults will be randomly assigned to get either the combo or the standard drug plus a …

This study tests whether adding atorvastatin, a widely used cholesterol-lowering drug, to standard tuberculosis (TB) antibiotics can help clear the infection faster and reduce lung damage. About 440 adults with pulmonary TB will receive either standard treatment alone or with dif…

This study tests whether a combination of clinical guidelines, feedback, and education can reduce the overuse of vancomycin in children with suspected sepsis in intensive care units. Over 52,000 patients and many clinicians across five hospitals will take part. The goal is to low…

This study tests two types of wound vacuum therapy for people with severe, flesh-eating infections. One method just uses suction, while the other also cleans the wound with a dilute bleach solution. Researchers want to see if the cleaning method leads to fewer hospital readmissio…

This study tests whether adding the antibiotic contezolid to the usual three-drug regimen can better reduce bacteria in the sputum of adults with Mycobacterium avium complex (MAC) lung disease. About 188 participants will receive either the standard treatment alone or with contez…

This study compares a rapid test that identifies pneumonia-causing bacteria in about one hour to standard lab methods that take 2-4 days. Researchers want to see if the faster test helps doctors choose the right antibiotics sooner for 150 hospitalized patients with pneumonia. The…

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

This study looks at whether offering a rapid syphilis test during family planning visits (for birth control or abortion) is practical and acceptable to patients. About 70 participants will get a fingerstick test with results in 10-15 minutes, instead of waiting days. The goal is …

This study is testing two new blood test kits designed to diagnose syphilis. Researchers will collect blood samples from 1000 people, including those with symptoms, those at high risk, and healthy controls. The goal is to see how accurate these new kits are compared to standard l…

Preterm babies face a serious risk of late-onset sepsis, an infection that can be hard to diagnose quickly. This study checks whether monocyte distribution width, a measurement taken from a standard blood count, can accurately identify which preterm babies have the infection. Res…

This study will test whether a new urine-based test can accurately diagnose pneumococcal pneumonia in children under 5 in Malawi. Researchers will use 350 stored urine samples from healthy kids and those with pneumonia, comparing results to standard lab methods. If it works, this…

This study will test a new biomarker called t6A to see if it can help doctors diagnose bacterial infections in newborn babies early. Researchers will measure t6A levels in 210 infants who need blood tests for suspected infection. The goal is to find a more accurate way to detect …

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual physical exam versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound improves acc…

This early study is testing a radioactive tracer called [18F]F-TMP that is injected into the body and then tracked with a PET/CT scan. The goal is to see if the tracer collects at sites of bacterial infection, making them visible on the scan. Twenty adults with known or suspected…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

Every year, millions of people with tuberculosis (TB) go undiagnosed. This study tests new, faster diagnostic tools that use a simple tongue swab instead of the usual sputum sample. Researchers will enroll 1,350 adults with cough or TB risk factors to see how accurate these point…

This study is testing new, non-invasive ways to diagnose tuberculosis (TB) in children under 15. Researchers will evaluate oral swabs, cough sound analysis, and lung sound analysis as potential alternatives to sputum tests. The goal is to find faster, simpler, and cheaper diagnos…

This study tests whether proteins in joint fluid, such as alpha-defensin, can quickly and accurately detect bacterial joint infections (septic arthritis) in children. Currently, doctors rely on cultures that take days, forcing tough decisions about emergency surgery. The trial co…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study tests whether a rapid finger-prick blood test for syphilis and HIV can be used in a prenatal clinic for pregnant people at risk. The test gives results in five minutes, potentially speeding up diagnosis and treatment. Participants will provide feedback on their experie…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study tests whether measuring a substance called IL-6 in the blood can quickly predict if an emergency room patient with a suspected infection will develop sepsis or septic shock. Researchers will enroll 450 adults admitted from the ER and track their outcomes for up to 30 d…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study tests a new, non-invasive tool called the POP-Score to predict infection in newborns within the first 6 hours of life. The score combines light-based measurements of muscle oxygen with routine vital signs like heart rate and blood pressure. Researchers will enroll 93 n…

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study tests whether a smartphone app can tell the difference between a TB cough and other coughs by analyzing audio recordings. Researchers will collect cough sounds from 1,751 people with a cough lasting at least two weeks, then use machine learning to build a quick screeni…

This study aims to find faster, simpler, and cheaper ways to diagnose tuberculosis (TB), a disease that kills over a million people each year. Researchers will test new diagnostic tools on over 26,000 adults in 10 countries who have a cough lasting two weeks or more, or who have …

This study aims to develop a better blood test for early Lyme disease in children. Current tests often miss early infections or give false positives. Researchers will also study the immune response and the types of Lyme bacteria involved. About 500 children with suspected Lyme di…

This study is testing whether measuring TB DNA in blood and urine can help diagnose tuberculosis and track treatment progress. Current TB tests can be slow or require invasive procedures. The trial will enroll 85 people with active TB, latent TB, or no TB to see how accurate the …

This pilot study tests a new blood test that looks at markers on white blood cells to tell if a feverish baby under 3 months has a serious bacterial infection. Researchers will collect an extra small blood sample from 180 infants in the emergency department. The goal is to see if…

This study is testing a new, quick test for gonorrhea in pregnant women and women with symptoms in South Africa. About 1,239 women will provide samples to see if the new test works as well as standard lab methods. The goal is to make diagnosis faster and easier, especially in cli…

This study is testing whether a new approach—using ultrasound to guide a tiny needle to collect fluid near the ulnar nerve, then analyzing it for leprosy bacteria DNA—can more accurately diagnose leprosy and confirm when it's cured. Researchers will follow 108 participants for on…

This study is testing a new laboratory method that looks for DNA fragments from tuberculosis bacteria in fluid around the lungs (pleural effusion). The goal is to see if this test can diagnose tuberculous pleurisy more accurately than current tests. Researchers will study 400 adu…

This study tests a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis using a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. If it …

This study is testing whether a blood test called Karius Spectrum can help doctors find infections faster in adults with weakened immune systems (e.g., organ transplant recipients, cancer patients). The test looks for DNA from bacteria, fungi, viruses, and parasites in the blood.…

This study tests whether a DNA sequencing test can help doctors choose the right antibiotics for people with drug-resistant tuberculosis (TB). Researchers will collect samples from 2,500 participants in clinics and use targeted sequencing to identify which drugs the TB bacteria a…

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a brain infection) in patients who have a brain drain (ventriculostomy). About 185 adults with suspected meningitis will have their spinal fluid tested. The go…

This study aims to see if a simple stool test can accurately detect Helicobacter pylori infection in children, avoiding the need for an invasive endoscopy under anesthesia. Researchers will compare the stool test results with standard biopsy results in 188 children aged 16 or you…

This study is testing whether a tiny camera in a pill (colon capsule endoscopy) can find colorectal cancer or precancerous growths in people who have had a bloodstream infection with certain gut bacteria. About 100 adults will swallow the camera 4-8 weeks after leaving the hospit…

This trial tests whether adding a quick blood test for presepsin can safely reduce unnecessary antibiotic use in very preterm infants. Currently, over 85% of these babies get antibiotics right after birth, but only 1 in 70 actually has an infection. The study will enroll 900 infa…

This study looks at whether combining blood and joint fluid tests can more accurately diagnose infections in people who need a second hip or knee replacement. Researchers will test 270 patients and compare the accuracy and cost of different markers. The goal is to help doctors de…

This study is testing whether a set of blood markers can accurately rule out late-onset sepsis in newborns in intensive care. Researchers will enroll 358 babies with signs of infection and compare the markers against a panel of experts. If the markers work well, doctors could avo…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinace…

This study tests a new drug called AZD5148 to see if it can prevent repeat C. diff infections in adults. About 230 people will get either the drug or a placebo as a single injection. The goal is to stop the infection from coming back after standard treatment.

Researchers are studying whether short-course preventive treatment protects high school and college freshmen with strongly positive TB skin tests from developing active tuberculosis. About 3,000 students across 26 schools in Meishan City, Sichuan Province, China, take either a 3-…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study tests whether a 4-week course of the drug bedaquiline can prevent tuberculosis (TB) as well as standard longer treatments. It involves 2,530 people living with HIV and close contacts of TB patients. The goal is to find a safer, easier-to-complete prevention option.

This study tests EXL01, a single strain of a beneficial gut bacterium (Faecalibacterium prausnitzii), to see if it can prevent repeat Clostridioides difficile infections in people at high risk. About 56 adults who have had at least two C. diff episodes will take EXL01 or a placeb…

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study will test whether screening pregnant women for chlamydia and gonorrhea can reduce the risk of preterm birth. About 2,000 women in Botswana will be randomly assigned to receive either standard care or additional STI testing early in pregnancy and again in the third trim…

This phase 3 trial tests whether a gradual taper of vancomycin is as good as a 10-day course of fidaxomicin at preventing another C. difficile infection. About 500 adults with a first or second C. diff episode will be randomly assigned to one of the two treatments. The main goal …

This study is looking at whether it's safe and effective to give the Tdap vaccine (for whooping cough) and the RSV vaccine at the same doctor's visit during pregnancy, or if they should be given separately. The researchers will recruit 60 healthy pregnant individuals and randomly…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study tests whether giving penicillin shots to pregnant women at high risk for syphilis can prevent infection. Researchers in Rio de Janeiro will enroll 500 women and compare the shots to standard care. Participants receive monthly injections and tests during their third tri…

This study tests if using antiseptic washes and placing antibiotics directly into the wound during hip or knee replacement surgery can lower the chance of a serious infection that requires another operation. Over 21,000 adults getting a joint replacement will be randomly assigned…

This phase 3 trial tests whether a combination of two antibiotics (bedaquiline and rifampicin) can better prevent leprosy than the current standard single dose of rifampicin. Over 124,000 people living near a leprosy patient in the Comoros will receive either the new two-dose reg…

This study aims to find a shorter, safer treatment for latent tuberculosis (TB) infection to prevent it from becoming active disease. About 1800 adults and children with a positive TB test will try one of several daily pill regimens lasting 1 to 4 months. The goal is to identify …

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study compares a new 6-week daily rifapentine regimen to the standard 12-16 week rifamycin-based treatment for latent tuberculosis infection (LTBI). The goal is to see if the shorter treatment is just as safe and effective at preventing active TB. About 3,400 people at highe…

This study in Uganda tests whether offering HIV self-testing and PrEP (a daily pill to prevent HIV) at home during routine TB contact tracing can increase HIV prevention. About 2,480 people from households with a TB patient will be randomly assigned to either home-based HIV testi…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study tests whether using a device that measures blood flow to the skin (called the peripheral perfusion index) can help doctors give fluids more precisely to elderly ICU patients with sepsis or shock. The goal is to prevent acute skin failure, a serious condition where the …

This study tests whether increasing kangaroo care (skin-to-skin contact) in neonatal intensive care units can reduce severe infections and antibiotic-resistant bacteria in very premature infants (born before 32 weeks). Over 3,000 babies across multiple hospitals will be involved.…

This study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fe…

This study tests whether taking a single 200 mg dose of doxycycline within 24–72 hours after unprotected sex can prevent gonorrhea, chlamydia, and syphilis in men who have sex with men. Researchers in Bangkok will enroll 400 participants and follow them for 12 weeks. If effective…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study tests whether providing targeted water, sanitation, and hygiene (WASH) supplies and education to households of cholera patients can reduce the spread of diarrhea. About 2,900 people in South Kivu, DRC, will take part. The goal is to see if these simple measures can pre…

This study tests a vaginal gel called Multi-Gyn UT Protect to see if it can prevent repeated urinary tract infections (UTIs) in women. Fifty adult women who have had multiple UTIs in the past year but no current infection will apply the gel twice a week for four months. Researche…

This study looks at whether taking antibiotics for just one day after a cat bite to the hand or forearm works as well as the usual five-day course, or even a placebo. About 72 adults who are bitten and seek care within 24 hours will be randomly assigned to one of three groups. Th…

This study is testing whether taking high-dose fish oil supplements during pregnancy can prevent asthma and persistent wheezing in early childhood. The trial will enroll 2000 pregnant Danish women with low blood levels of omega-3s. Participants take fish oil or placebo capsules d…

This study is testing whether taking a higher dose of vitamin D during pregnancy can prevent asthma and persistent wheezing in children up to age 3. Researchers will give 2000 pregnant women either vitamin D or a placebo daily from week 22-26 of pregnancy until one week after del…

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This study tests whether washing the bladder with a harmless strain of E. coli can prevent recurrent urinary tract infections (UTIs) in people who have failed other treatments. Researchers will compare the harmless bacteria wash to a saltwater wash in 80 participants, tracking ho…

This study in Bangladesh tests whether giving a single dose of the antibiotic rifampin to people who live with or near leprosy patients can prevent infection. Researchers will use a new fingerprick blood test to measure infection markers before and after treatment. The goal is to…

This study compares two sedation methods for elderly ICU patients (65+) who need a breathing tube. One group gets a mix of propofol and ketamine, the other gets propofol alone. The goal is to see which causes fewer dangerous drops in blood pressure. The trial involves 41 particip…

Researchers are testing whether inhaling a concentrated saltwater mist, added to standard supportive care, can improve quality of life and help clear Mycobacterium avium complex (MAC) bacteria from the lungs. The trial enrolls 30 adults with nodular-bronchiectatic MAC lung diseas…

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

Researchers at Minia University are testing whether the shape of a single-file rotary dental instrument affects how much debris gets pushed out of the root tip during a root canal, and whether that changes how much pain patients feel afterward. Thirty teeth with irreversible pulp…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

Researchers are testing whether taking omega-3 fish oil capsules every day for eight weeks, alongside standard tuberculosis treatment, helps the body clear the infection faster and lowers inflammation. The trial enrolls 40 adults aged 18 to 45 with newly diagnosed, drug-sensitive…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This trial tests two ways of activating cleaning solutions during a repeat root canal procedure to see if one leads to less pain and better healing. Adults with a failed root canal in a single-rooted tooth will be randomly assigned to receive either Xp Finisher R file activation …

This trial tests three pain-relief approaches after a single-visit root canal in people with symptomatic irreversible pulpitis, a painful tooth condition. Participants receive either acetaminophen, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen for three da…

This pilot study tests whether VM100, a nutritional supplement made from ten natural ingredients, can improve quality of life for people with Duchenne muscular dystrophy (DMD). About 20 participants aged 8 and older will take VM100 or a placebo for 10 weeks. Researchers will meas…

This study compares two ways to numb a painful lower back tooth before a root canal. One method uses a standard injection near the jaw nerve, while the other uses a different numbing medicine injected near the tooth. The goal is to see which approach provides better pain relief d…

This study tests whether injecting the steroid dexamethasone near the tooth ligament or under the gum helps numb the tooth better and reduces pain during root canal treatment. It includes 84 adults with severe, irreversible pulpitis in a lower molar. Participants receive one of t…

This study tests whether inhaling a salty mist (3% hypertonic saline) can improve breathing symptoms in people with nontuberculous mycobacterial (NTM) lung disease who haven't yet started antibiotics. About 262 adults will either start the saltwater treatment right away for 6 mon…

This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly …

This study looks at whether children with pneumonia caused by Mycoplasma bacteria need antibiotics to get better. About 376 children aged 3-17 will receive either a placebo (inactive pill) or a common antibiotic. Researchers will track how long symptoms like fever and fast breath…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study looks at whether regularly flushing chest drains with salt water helps keep them from getting blocked in people with serious lung infections (empyema). The goal is to see if this simple step can shorten the time the drain needs to stay in, reduce hospital stays, and im…

This study looks at two types of dental sealers used in root canals to see which one causes less pain afterward. About 50 adults with tooth pain will get one of the two sealers and report their pain for three days. The goal is to help dentists choose the sealer that makes root ca…

This study tests two different dental file systems—EdgeOne Fire (reciprocating motion) and Jizai (rotary motion)—to see which causes less pain during and after root canal treatment in upper premolars with infected pulp. Fifty-six adults with moderate spontaneous pain will be rand…

This study aims to understand how Staphylococcus aureus bacteria interact with human cells to cause infections, especially in the spine. Researchers will use tonsil tissue discarded after routine tonsillectomies to create lab models. About 500 participants aged 2 and older who ar…

This study looks at how healthy people's skin and immune system respond to tick bites. Researchers will place clean, lab-bred ticks on volunteers' skin and take small skin samples and blood to track changes. The goal is to understand tick resistance and help design future vaccine…

This study aims to understand how the environment, the bacteria that cause melioidosis, and the human body interact to cause disease. Researchers will follow about 1,000 infected patients and 1,000 healthy matched controls in Thailand, Laos, and Cambodia for one year. They will a…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

Researchers are running an observational registry to study whether vonoprazan, an oral drug for heartburn and acid reflux, is safe to take during pregnancy. The study follows women aged 15 to 50 who took vonoprazan while pregnant and compares their outcomes with women who did not…

This study aims to better understand trisomy 8 mosaicism, a rare genetic condition where some cells have an extra copy of chromosome 8, and its link to autoinflammatory disease (TRIAD). Researchers will follow affected individuals and their healthy relatives over time, collecting…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other organ infections. Researchers will study up to 1,000 participants to understand the genetics, symptoms, and best treatments for these infections. The study also…

Researchers at a dental institute in India are studying whether levels of two inflammation markers, IL-1beta and IL-6, in the tooth's pulp can predict how well a full pulpotomy works. The procedure removes the inflamed crown portion of the pulp, caps it with a mineral-based mater…

Vasoplegic shock is a life-threatening drop in blood pressure that can lead to organ failure. Doctors at University Medical Centre Maribor are studying patients whose blood pressure stays too low despite standard drugs. They measure renin, an enzyme tied to blood pressure regulat…

Researchers in Moscow are studying patients who have knee or hip replacement surgery to learn why some develop serious infections around the implant. The study will follow 750 adults aged 45 and older, checking their immune status, mineral metabolism, and tissue samples before an…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study looks at why the antibiotic doxycycline, when taken after sex, prevents bacterial STIs in some people but not others. Researchers will measure doxycycline levels in hair, blood, and urine from 48 volunteers to develop better ways to track if people are taking the medic…

Researchers in Ethiopia are studying whether tuberculosis infection changes how the placenta develops and works. They will enroll 500 pregnant women at delivery clinics and use a blood test to identify those with TB infection. The team will compare placental tissue and infant out…

Researchers at University Hospital Bonn are following 300 adults who undergo knee or hip replacement surgery to understand how their recovery unfolds. The study measures quality of life, hand grip strength, and bone density before and after the procedure. The goal is to identify …

This study follows 150 people with active or latent tuberculosis (TB) to collect blood, sputum, and tissue samples. The goal is to better understand how TB behaves in the body and how the immune system responds. Participants receive standard TB treatment as part of the study, but…

This study is recruiting 100 adults with hard-to-treat nontuberculous mycobacterial (NTM) lung infections to see if phage therapy—using viruses that kill bacteria—can help. Researchers will collect blood and airway samples to find biological markers that show whether the treatmen…

This study aims to understand why some people with tuberculosis (TB) experience a paradoxical reaction, where they initially improve on treatment but then suddenly get worse. Researchers will follow 140 adults with TB, with or without signs of this reaction, using blood tests, ur…

This study will collect ear swabs from 40 people with malignant otitis externa, a severe infection of the ear canal that mainly affects people with diabetes or weakened immune systems. Researchers will culture the samples to identify the bacteria and fungi causing the infection a…

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study looks at how the antibiotic rifampicin is processed by the body in people with staphylococcal bone and joint infections, such as prosthetic joint infections and chronic osteomyelitis. Researchers will take blood samples from 40 participants to measure drug levels and b…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study looks at whether a simple bedside check called capillary refill time (pressing on a fingernail to see how fast color returns) can be combined with a blood test to spot a hidden problem in septic shock. Sometimes blood flow to organs seems normal, but tissues are still …

This study tests whether point-of-care STI tests, which give results in about 10 minutes, can speed up treatment for pregnant women compared to standard lab tests. About 756 pregnant women at Grady Memorial Hospital will either get the rapid tests or standard testing. The goal is…

This study is investigating whether germs called non-tuberculous mycobacteria (NTM) found in home water systems and dust can cause lung infections in people with cystic fibrosis. Researchers will collect samples from the homes of 120 CF patients—some with NTM infections and some …

This study looks at whether adults with cystic fibrosis can collect sputum samples at home and mail them in for infection testing, compared to standard clinic collection. With 150 participants, researchers will compare how well home samples detect bacteria like Pseudomonas aerugi…

This study investigates whether certain Helicobacter bacteria other than H. pylori are present in people with various stomach conditions, including chronic gastritis, precancerous changes, and gastric cancer. Researchers will analyze biopsy samples from about 150 patients to meas…

This study is building a large national registry to track the safety and effectiveness of fecal microbiota transplantation (FMT) in patients with Clostridium difficile infections. It will follow adult patients receiving FMT as part of their routine care, as well as stool donors, …

This study collects urine samples from adults who use intermittent catheters, both during urinary tract infections (UTIs) and during symptom-free periods. The goal is to explore basic urine characteristics, like bacterial counts, to better understand UTIs in this group. No treatm…

This registry study follows pregnant individuals aged 10 to 25 who received PENBRAYA, a vaccine against meningococcal disease, during pregnancy or within 30 days before their last period. The goal is to collect information on pregnancy outcomes and infant health during the first …

This study is tracking how adults with meningitis are treated in about 30 hospitals across Brazil. Researchers will follow 624 patients during their hospital stay and after discharge to see what treatments work best and how patients recover. The goal is to gather real-world evide…

This study looks at whether adding certain nutrients to blood cells from people with septic shock can help restore the cells' energy-making machinery (mitochondria). Researchers will collect blood samples from 55 patients in the ICU and test these nutrients in the lab. The goal i…

This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished an…

This study looks at how a Campylobacter gut infection changes the bacteria and lining of the bowel, and whether these changes can help identify who might later develop irritable bowel syndrome (IBS). Researchers will follow people with a confirmed Campylobacter infection who do n…

This study looks at how two antibiotics, ceftriaxone and benzathine penicillin G, are processed by the body during pregnancy. Up to 78 pregnant women in the U.S. will take one of these drugs as part of their regular care, and researchers will measure drug levels in their blood. T…

This study aims to develop a predictive model for mortality in critically ill patients who carry multidrug-resistant gram-negative bacteria (MDR-GNB). Researchers will follow about 1,500 adults in intensive care units (ICUs) who are colonized with these bacteria, tracking their i…

This study looks at whether the color-coded triage system (Red, Yellow, Green) used in Turkish emergency departments can accurately predict which children with fever will become seriously ill. Researchers will track 3,000 children aged 0-18 who come to the emergency room with a f…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

This study follows intensive care unit (ICU) patients over at least 28 days to see how two types of bacteria—Klebsiella pneumoniae and Enterobacter cloacae—change and evolve in their gut. By analyzing weekly stool samples, researchers hope to understand how these bacteria become …

This study follows 400 adults who receive a Double-J ureteral stent—a tube that helps drain urine from the kidney to the bladder. The goal is to identify risk factors for bacteria sticking to the stent and to see how this colonization relates to urinary tract infections, antibiot…

This trial tests whether button-sized wireless sensors can accurately measure heart rate, oxygen levels, and skin temperature in extremely preterm infants in the NICU. The sensors aim to replace bulky wired monitors that can stress fragile babies. Ten stable preterm infants will …

This study looks at whether the presence and distribution of H. pylori bacteria in the stomach, along with tissue features of early gastric cancer, can help predict how the cancer will behave and what the long-term outlook may be. Researchers will analyze data from about 1,500 pe…

This study tests whether it is possible to set up a system to monitor antibiotic resistance at a general referral hospital in semirural Kinshasa, Democratic Republic of Congo. Researchers will enroll about 210 patients with suspected bloodstream infections to collect blood sample…

This study tests whether adding electrochemical sensors to standard blood culture bottles can identify bacteria early, while the sample is still growing. Researchers will collect extra blood samples from 200 patients with suspected bloodstream infections and spike them with known…

This study looks at 750 people who have finished treatment for drug-sensitive tuberculosis. Researchers will test new sputum and blood-based methods to see if they can predict whether the disease will come back within a year. The goal is to find better ways to measure treatment s…

This registry collects detailed information from 1,000 patients with infective endocarditis, a serious heart infection. Researchers will track demographics, microbiology, imaging, and outcomes to understand current treatment effectiveness and guide future studies. The goal is to …

This observational study follows 800 adults who receive Myriad™ during soft tissue reconstruction for wounds like abdominal dehiscence, pressure injuries, or anal fistulas. Researchers track healing time, complications, and side effects to understand how well the material works i…

This study looks at whether blood cancer patients with a serious infection can safely stop antibiotics sooner if they are stable for 72 hours, instead of the usual 10-day course. About 172 adults will be randomly assigned to either a personalized short course or standard long cou…

This study investigates why some patients with septic shock develop a weakened immune system after the initial crisis, making them prone to further infections. Researchers will analyze blood samples from 305 intensive care unit patients to find biological markers that indicate im…

This study looks at whether muscle measurements from a CT scan taken when a patient is admitted to the ICU for septic shock can predict their risk of dying within 3 months after leaving the ICU. Researchers will analyze muscle size, density, and fat content from the scan and comp…

This study follows 300 health workers in Cape Town, South Africa, who are at high risk of tuberculosis (TB) infection. Researchers will use a combination of existing and new tests every three months to track immune responses at the time of infection. The goal is to better underst…

This study looks at whether measuring certain immune and inflammatory markers in the blood can help predict how critically ill patients will fare. Researchers are following 200 adults in intensive care who have infections, have had major surgery, or have weakened immune systems. …

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study looks at bile acid profiles in children with ulcerative colitis (UC) who also have a C. difficile infection. Researchers want to see if changes in bile acids and gut bacteria make these children more vulnerable. They will compare three groups: children with UC flare-up…

This study compares two methods for guiding early treatment in people with septic shock, a severe infection that can cause organ failure. The standard approach uses blood lactate levels, but this trial tests whether using the CO2 gap (a measure of blood flow) is better at reducin…

This study looks at 790 adults with S. maltophilia infections, a hard-to-treat bacteria. Researchers will compare patients who got one antibiotic versus those who got a combination, to see which group has fewer deaths within 30 days. The goal is to find the best treatment approac…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study is observing 200 patients who received a large leg implant (megaprosthesis) between 2020 and 2023. Researchers want to learn how many get infections, what puts them at risk, and how those infections turn out. The goal is to gather information, not to test a new treatme…

This study will follow 2000 adults in France who are starting treatment for tuberculosis. Researchers will collect health data and samples like blood, urine, and breath over two years to see how well treatments work. The goal is to learn more about TB care and build a biobank for…

This observational study is looking at how two antibiotics, ceftazidime/avibactam and fosfomycin, work in the body to treat infections caused by carbapenem-resistant Enterobacterales (CRE), a type of superbug. Researchers will monitor 60 adult patients to see if the drug levels i…

This study looks at how different types of mycobacterial infections, including drug-resistant tuberculosis and nontuberculous mycobacteria, change the body's immune response. Researchers will collect blood and other samples from 120 participants, including healthy people and thos…

This study looks at whether sleep habits of 11-12 year olds affect their immune response to the meningococcal vaccine (MCV4). About 66 healthy teens will wear a sleep tracker and keep their normal sleep schedule for 5 weeks. Researchers will measure antibody levels after vaccinat…

This study looks at how the cystic fibrosis drug ETI affects the way the body handles antibiotics. Researchers want to see if people on ETI need lower antibiotic doses to treat lung infections, which could reduce harmful side effects like hearing loss or kidney damage. The study …

This study looks at how well the MenFive (NmCV-5) meningitis vaccine still works more than five years after a single shot. Researchers will test the blood of 450 people in Mali and The Gambia who got the vaccine when they were 2 to 29 years old. The goal is to see if their immune…

This study looks at small molecules called miRNAs in the blood of patients with septic shock. The goal is to understand why some patients develop a weakened immune system after sepsis, which can lead to more infections and higher risk of death. Researchers will compare miRNA patt…

This study examines why some people with a painful tooth infection (irreversible pulpitis) don't get fully numb from a standard dental injection. Researchers will measure levels of certain genes and inflammatory markers in the tooth pulp to see if they predict anesthesia success.…

This study looks back at the medical records of 150 patients who died in intensive care between 2018 and 2022 after being treated for a joint prosthesis infection. The goal is to understand what went wrong and identify patterns that could help doctors better manage similar cases …

This study helps U.S. healthcare centers figure out if patients are getting NTM lung infections from the hospital environment. Researchers will compare germs from patients' lungs with germs from water and dust in the hospital and homes. The goal is to create a standard method to …

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study is observing 200 hospitalized adults with carbapenem-resistant Acinetobacter baumannii (CRAB) infections—a type of superbug—who are treated with the antibiotic sulbactam-durlobactam. Researchers will compare their outcomes to patients receiving other treatments to see …

This study prepares medical sites in Kenya, Malawi, Mozambique, and Uganda for future trials of a vaccine against Group B Streptococcus (GBS), a leading cause of serious infections in newborns. Researchers will track pregnancy and infant health data and monitor GBS cases in babie…

This study looks at whether urine samples can show immune markers of chlamydia infection in women. Participants provide urine, vaginal, and blood samples to compare immune responses. The goal is to find easier ways to study chlamydia immunity, which could help develop better test…

This study looks at whether frailty—measured by a simple scale—can predict death in adults aged 18 to 65 admitted to intensive care for septic shock. Researchers will track 200 patients to see if those who are frail have a higher risk of dying within 28 days, even after accountin…

This study tests whether offering a small cash payment to households can encourage more people to get screened for tuberculosis (TB) in rural Tanzania. Researchers will enroll 360 people recently diagnosed with TB and their families. Half will receive the usual care, and half wil…

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study looks at the bacteria living in the lungs of people with active tuberculosis (TB) and how they change with treatment. Researchers will compare lung bacteria in diseased and healthy areas, and also check the mouth, nose, and gut. They aim to understand how these microbe…

This study collects blood from 50 women in Uganda who previously received an experimental group B strep (GBS) vaccine during pregnancy. The blood is used to create quality control panels that help labs accurately measure vaccine-induced antibodies. The goal is to improve testing …

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This study is observing 2,500 children in France to understand how pneumococcal vaccines have changed the severity and types of pneumococcal infections. Researchers will look at which bacterial strains cause disease, how severe the infections are, and whether children were vaccin…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in…

This study compares the immune response to COVID-19 vaccines between people being treated for tuberculosis (TB) and healthy individuals. About 133 participants in the Thailand-Myanmar border area will receive one of three vaccines (Pfizer, AstraZeneca, or Janssen). Researchers wi…

This study explores whether measuring tiny DNA fragments from the TB bacteria in the blood can help doctors monitor how well treatment is working. Researchers will enroll 140 adults with newly diagnosed TB in Thailand, taking blood samples over time to see if the DNA levels drop …

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 people will receive either a cholera vaccine or a typhoid vaccine (as a comparison) and give blood samples over two years. The goal is to f…

This study aims to understand why some children develop severe bacterial infections that require intensive care. Researchers will analyze blood samples and medical histories from 1,401 children who were hospitalized for such infections between 2015 and 2018 in France. By comparin…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syph…

This registry will follow 10,000 people in Shandong, China, who are being treated for H. pylori infection. Doctors will prescribe standard treatments based on guidelines, and researchers will track how well each treatment works and any side effects. The goal is to learn which str…

This study looks at whether a new blood gas ratio can help predict which patients with septic shock are more likely to survive. Researchers will measure this ratio and compare it to standard lactate levels in 30 adults with septic shock. The goal is to see if the ratio gives earl…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank. The goal is to understand why stomach cancer is more common in the We…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study will follow 3,000 children hospitalized with severe bacterial infections to understand what makes them so dangerous. Researchers will collect data on the bacteria, the children's health, and the care they receive. The goal is to find risk factors and early warning sign…

This study looks at the sticky layer (biofilm) that can form on arterial catheters in intensive care patients. About 60 adults in the ICU will have their catheters examined after removal to see what types of bacteria or fungi are present and how the biofilm is structured. The goa…

This study follows 50 adults with infected hip replacements treated at University Hospitals Leuven. Researchers will track which treatments (antibiotics or surgery) work best and note complications. The goal is to gather real-world data to help doctors and patients make better de…

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study follows 100 hospitalized patients with Clostridioides difficile infection to track how quickly the bacteria clears from the gut during and after standard antibiotic treatment. Researchers will also analyze gut bacteria and immune responses in stool samples to identify …

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study looks at how well the Triathlon Hinge Knee System works in people who need knee replacement surgery, either for the first time or to fix a previous one. Researchers will follow about 200 patients for up to 10 years to see how long the implant lasts and how well patient…

This study looks at children ages 5 to 15 who test positive for strep throat to understand why some become carriers—meaning they have the bacteria but no symptoms. Researchers will collect throat samples and analyze gene activity to compare carriers with those who have active inf…

This study measures the amount of free cloxacillin in the blood of adults receiving the drug as a continuous infusion for severe staph infections. Researchers want to ensure levels are not too high or too low. They will use this data to create a model that predicts the right dose…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study looks at how well the Oxiris blood filter removes harmful toxins in adults with septic shock in the ICU. Researchers will take blood samples before and after the filter over 24 hours to see when it stops working. No new treatment is given—just observation. The goal is …

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This study tests a rapid PCR test that identifies bacteria and drug resistance in about an hour, compared to standard methods that take 1-3 days. 300 adults with bloodstream infections will be randomly assigned to get either the rapid test plus standard care or standard care alon…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system in people with sepsis. Researchers will analyze blood samples from 116 ICU patients with sepsis to see if these elements are linked to higher de…

This study watches 200 adults with C. diff infection to see how standard antibiotics and fecal microbiota transplantation (FMT) help people recover. Researchers will collect stool, blood, and urine samples over up to 5 years to understand why some treatments succeed and others fa…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This study looks at 300 adults hospitalized with rare but life-threatening flesh-eating infections (necrotizing soft tissue infections). Researchers want to find out which early signs and routine lab tests can predict who is most likely to die during their hospital stay. The goal…

This study is a national registry that will follow up to 4,000 people who receive a fecal microbiota transplant (FMT) for C. diff infection or other gut conditions. Researchers will track side effects, infections, and whether the disease comes back. The goal is to better understa…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at how a person's sex and gender might change their immune system's reaction to the meningitis B vaccine. Researchers will compare immune responses in transgender and cisgender adults aged 18 to 50. The goal is to better understand why men and women often respond…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening infection that affects the whole body. Researchers will use existing heart ultrasound data from 60 adults to see if the measurements agree and can b…

This study looks at cases of severe Lyme disease (disseminated borreliosis) in patients who have received anti-CD20 therapy, a type of immune-suppressing treatment. Researchers want to describe the symptoms, severity, and progression of the infection in these patients. The study …

This study is looking back at medical records of 400 adults hospitalized with a serious strep blood infection (Streptococcus anginosus group). The goal is to find out which factors are linked to a higher chance of dying within 28 days. By understanding these risk factors, doctors…

This study looks back at cases of recurrent borreliosis, a bacterial infection spread by ticks or lice, diagnosed in France between 2013 and 2025. Researchers will describe the symptoms, where patients got infected, which Borrelia species caused the illness, and how it was diagno…

This study tests whether using changes in procalcitonin levels over time (kinetics) is better than a single measurement for deciding when to start antibiotics in critically ill patients with suspected infection. About 250 adults in the ICU will be randomly assigned to one of two …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study looks at the best way to stop the blood pressure medication vasopressin in people with septic shock. It compares slowly reducing the dose versus stopping it all at once. The goal is to see which method causes fewer dangerous drops in blood pressure. The study involves …

This study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study looks at 700 adults with Enterococcus faecalis bloodstream infection, a condition with a 15-25% death rate. Researchers compare patients who received one antibiotic versus a combination of antibiotics to see which approach reduces deaths and complications. The goal is …

This study uses a technique called microdialysis to measure antibiotic levels directly inside the hip joint after surgery for an infected hip replacement. Researchers want to see how well local antibiotics from a cement spacer work and compare them to levels in the blood. The goa…

This study uses a technique called microdialysis to measure antibiotic levels inside the knee joint after surgery for a knee replacement infection. Researchers will place a tiny probe in the joint to collect fluid samples during the hospital stay (about 14 days). They want to see…

This study is creating a data bank to better understand vaginal conditions like vulvodynia, yeast infections, bacterial vaginosis, and preterm labor. Researchers will look at proteins, immune markers, and vaginal bacteria in 550 women, including healthy volunteers and those with …

This study watches how doctors use vasopressin, a second blood pressure drug, in adults with septic shock in the ICU. It aims to see if starting it earlier lowers death rates and helps protect kidney function. Researchers will track 1,200 patients to gather real-world data.

This study compares two ways to manage fluids in cirrhosis patients with severe sepsis or septic shock. One method uses a bedside heart ultrasound (POCUS) to guide fluid amounts, while the other follows standard sepsis guidelines. The goal is to see if ultrasound-guided care redu…

This study follows 600 people at higher risk for stomach cancer to track precancerous changes in the stomach lining. Researchers collect tissue, blood, and saliva samples during routine endoscopies. The goal is to understand why some people's stomach changes progress to cancer wh…

This study creates a global registry to collect information from 200 people with leptospirosis, a bacterial infection caught from animals or contaminated water. Researchers will track how the disease spreads, what treatments work, and why some patients get very sick. No new treat…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This observational study is watching how the body's metabolism changes when septic shock patients receive a rapid fluid infusion. Researchers will measure oxygen use and other markers before and after the fluid challenge in 120 adults. The goal is to find patterns that could guid…

This study looks at whether people with a staph bloodstream infection and a low risk score (VIRSTA score less than 3) can safely avoid a routine heart ultrasound. About 700 participants will be randomly assigned to either get the ultrasound or not. The goal is to see if skipping …

This study tests whether using computer models to personalize tuberculosis (TB) drug doses can help patients reach optimal drug levels faster. Researchers will monitor 30 adults with pulmonary TB who are already on standard treatment. The goal is to see if this approach helps doc…

This study aims to develop new antibody treatments for Pseudomonas aeruginosa, a bacteria that can be resistant to many antibiotics. Researchers will collect blood from 30 patients who have had this infection to isolate and produce antibodies that can fight the bacteria. The goal…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…

This study aims to find more tuberculosis (TB) cases by improving diagnostic tools already available in local health clinics. About 1,584 adults with TB symptoms in Guinea-Bissau and Ethiopia will be randomly assigned to either standard care or an enhanced testing approach that i…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study aims to find genetic reasons why some people, especially younger ones without other health issues, develop severe listeriosis from contaminated food. Researchers will collect blood, skin, and saliva samples from 100 patients and their relatives. The goal is to identify…

This study will roll out three proven antibiotic stewardship strategies in Dutch hospitals to see if they reduce unnecessary antibiotic use in newborns with suspected early-onset sepsis. Researchers will compare data from before and after the strategies are put in place, involvin…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…

This study will check the lung health of 50 adults who finished treatment for tuberculosis (TB) in Liverpool, UK, about one year after their treatment ended. Participants will take a breathing test and answer questions about their health and wellbeing. The goal is to find out how…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…