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Could cutting back on IV fluids save lives in septic shock?

NCT ID NCT06140147

Disease control Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 2 times

Summary

This study is testing whether giving fewer non-essential fluids to adults with septic shock can improve outcomes. The trial will enroll 1,850 patients in intensive care, comparing a restrictive fluid strategy to usual care. The main goal is to see if this approach reduces deaths and serious complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
protocolized reduction of non-resuscitation fluids (intravenous fluids, enteral water, nutrition, and glucose)
What this could lead to
If successful, this could establish a safer fluid management strategy for septic shock, potentially reducing deaths and complications in intensive care.
What could go wrong
This is a large but early-stage trial without a defined phase. The intervention is a change in clinical practice, not a new drug, so benefits may be modest. There is a risk of dehydration or electrolyte imbalances if fluids are overly restricted.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,850 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (≥ 18 years of age) * Septic shock according to the Sepsis 3 criteria at any time within 12 hours after ICU admission (suspected or confirmed infection, plasma lactate above 2 mmol/L, and infusion of vasopressor/inotrope to maintain mean arterial pressure of 65mmHg or above after receiving adequate fluid resuscitation \[\> 1L within 12 h of screening\]) and need for vasopressors at the time of screening. Exclusion Criteria: * Confirmed or suspected pregnancy * Previous inclusion in the trial * Screened more than 12 hours after ICU admission

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Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Septic shock

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    22 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Danderyd Hospital

    RECRUITING

    Danderyd, Sweden

  • Falun Hospital

    RECRUITING

    Falun, Sweden

  • Halmstad Hospital

    RECRUITING

    Halmstad, Sweden

  • Helsingborg Hospital

    RECRUITING

    Helsingborg, Sweden

  • Helsinki University Hospital

    RECRUITING

    Helsinki, Finland

  • Kuopio University Hospital

    NOT_YET_RECRUITING

    Kuopio, Finland

  • Malar Hospital

    RECRUITING

    Eskilstuna, Sweden

  • Norrtälje Hospital

    RECRUITING

    Norrtälje, Sweden

  • Sahlgrenska University Hospital

    RECRUITING

    Gothenburg, Sweden

  • Skåne University Hospital, Lund

    RECRUITING

    Lund, Sweden

  • Skåne University Hospital, Malmö

    RECRUITING

    Malmö, Sweden

  • Stockholm South General Hospital (SÖS)

    RECRUITING

    Stockholm, Sweden

  • Södertälje Hospital

    RECRUITING

    Södertälje, Sweden

  • Tampere University Hospital

    RECRUITING

    Tampere, Finland

  • Turku University Hospital

    NOT_YET_RECRUITING

    Turku, Finland

  • University Hospital of Umeå

    RECRUITING

    Umeå, Sweden

  • University Hospital of Wales

    NOT_YET_RECRUITING

    Cardiff, United Kingdom

  • Uppsala University Hospital

    RECRUITING

    Uppsala, Sweden

  • Varberg Hospital

    RECRUITING

    Varberg, Sweden

  • Örebro University Hospital

    RECRUITING

    Örebro, Sweden

  • Östersund Hospital

    RECRUITING

    Östersund, Sweden

  • Östra Hospital

    RECRUITING

    Gothenburg, Sweden

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