New score could help doctors spot fungal pneumonia faster
NCT ID NCT07681583
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to see how well it works. The goal is to improve early diagnosis and guide timely treatment for this serious lung infection.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this prediction score could help doctors diagnose fungal pneumonia earlier, leading to faster treatment and better outcomes for patients.
- What could go wrong
- This is an observational study, not a treatment trial. The score may not perform as well in other hospitals or patient groups, and it needs further validation before widespread use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 400 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Nov 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients presenting with pneumonia at Careggi University Hospital who underwent microbiological evaluation of lower respiratory tract samples, including bronchoalveolar lavage, bronchial aspirate, or endotracheal aspirate, within 48 hours of hospital presentation. The study population includes patients with microbiologically confirmed fungal, bacterial, or viral pneumonia enrolled in retrospective and prospective cohorts for derivation and validation of the FUNGAL-P clinical prediction score.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years and ≤90 years. * Presentation to the Emergency Department or hospital with pneumonia. * Pneumonia defined according to IDSA/ATS criteria as the presence of at least two clinical signs or symptoms of lower respiratory tract infection (temperature \<36.0°C or \>38.0°C, respiratory rate \>20 breaths/min, oxygen saturation \<90% on room air, arterial PaO₂ \<60 mmHg, cough, sputum production, white blood cell count \<4,000/μL or \>10,000/μL, or bandemia \>10%) together with radiographic evidence of a new pulmonary infiltrate or cavitary lesion. * Bronchoalveolar lavage (BAL), bronchial aspirate (BAS), or endotracheal aspirate (ETA) performed within 48 hours of hospital presentation. * Modified Rankin Scale score \<5. * Availability of microbiological investigations for identification of fungal, bacterial, or viral pathogens. * Provision of informed consent, when required by applicable regulations and ethics committee approval. Exclusion Criteria: * Refusal or withdrawal of informed consent. * Age \<18 years or \>90 years. * Pregnancy. * Expected life expectancy \<3 months. * Hospital-acquired pneumonia with onset \>48 hours after hospital admission. * Modified Rankin Scale score ≥5. * Absence of microbiological diagnostic evaluation. * No identified bacterial, fungal, or viral pathogen after microbiological investigations.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Careggi University Hospital
RECRUITINGFlorence, Italy
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