Cholera

This trial tests a new oral cholera vaccine called PanChol in healthy adults aged 18 to 55 in Zambia. The vaccine is designed to be safer and more effective than current options. Researchers will monitor participants for side effects and measure their immune response after vaccin…

This study tests a new cholera vaccine (OSP:rTTHc CCV) in 390 healthy adults and children aged 1 to 45 in a region where cholera is common. The goal is to see if the vaccine is safe and triggers a strong immune response. Some participants get the vaccine with or without an adjuva…

This study in Nairobi, Kenya, is testing whether giving the oral cholera vaccine Euvichol-S at longer intervals (3 months or 12 months) works as well as the standard 2-week schedule. Over 1,000 healthy participants aged 1 year and older will be randomly assigned to one of three d…

This study tests a new oral cholera vaccine (Biovac OCV-S) to see if it works as well as a currently approved vaccine (Euvichol-Plus). About 2,824 healthy people aged 1 to 45, including some adults living with HIV, will receive two doses. Researchers will check immune responses a…

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study tests a targeted approach to stop cholera spread in Dhaka, Bangladesh. When someone tests positive for cholera, their household and nearby neighbors (within about 20–40 meters) are offered an oral cholera vaccine. The goal is to see if this ring vaccination reduces the…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests whether providing targeted water, sanitation, and hygiene (WASH) supplies and education to households of cholera patients can reduce the spread of diarrhea. About 2,900 people in South Kivu, DRC, will take part. The goal is to see if these simple measures can pre…

This study aims to see if a 7-day water, sanitation, and hygiene program can reduce cholera infections in neighborhoods where a cholera patient lives. About 3,140 people will take part, focusing on homes without running water. The program provides practical tools and education to…

This study looks for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 people will receive either a cholera vaccine or a typhoid vaccine (as a comparison) and give blood samples over two years. The goal is to f…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…