Global hunt launched to unravel hidden dangers of rat urine disease
NCT ID NCT04288674
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study creates a global registry to collect information from 200 people with leptospirosis, a bacterial infection caught from animals or contaminated water. Researchers will track how the disease spreads, what treatments work, and why some patients get very sick. No new treatments are tested; the goal is to better understand the disease to improve future care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2020
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Retrospective data collection from patients with cultural, serological, molecular or histological evidence of Leptospirosis spp. infection and clinical evidence of invasive leptospirosis disease (acute kidney injury, pulmonary manifestation with acute respiratory distress syndrome (ARDS), myocarditis with arrhythmia, hepatic dysfunction, hemorrhage, multi-organ failure). Particularly, controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital).
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cultural, serological, molecular or histological evidence of invasive leptospirosis diseases * Clinical signs of disseminated leptospirosis disease without cultural, serological, molecular or histological evidence * Case controls: Matching procedures for controls: Particularly, case controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital). Exclusion Criteria: * Colonization or other non-invasive infection * Cultural, serological, molecular or histological evidence without dissemination
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Hospital of Cologne
RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a common antioxidant shield kidneys from leptospirosis?
- Prison walls may not stop Animal-Borne diseases
- Can we predict who will suffer severe leptospirosis?
- Could leptospirosis leave lasting damage? a new study investigates
- Scientists investigate immune system failures in leptospirosis to find better treatments
- Can plasma transfusion and blood filtering save lives in leptospirosis?