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Scientists investigate immune system failures in leptospirosis to find better treatments

NCT ID NCT07611591

Knowledge-focused Sponsor: Institut Pasteur Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the immune system of people with leptospirosis responds to the infection and to antibiotics. Researchers will collect blood samples from 70 adults in New Caledonia before and after antibiotic treatment to measure immune cell activity. They will also test a new approach using natural immunoglobulins to help the body better fight the bacteria. The goal is to understand why the immune system struggles and find ways to improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals presenting at the emergency department of the Territorial Hospital Center of New Caledonia with signs and symptoms of leptospirosis:

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be of legal age (18 years or older at the time of enrollment), * Be capable of understanding and providing informed consent, * Have received information and provided written consent, * Be enrolled in a social security program. * Be suspected of having leptospirosis Exclusion Criteria: * With a chronic inflammatory disease, * Whose health condition is incompatible with additional blood draws totaling 40 ml, * Receiving concomitant treatment with antibiotics and/or anti-inflammatory drugs, or undergoing medical treatment incompatible with the study's objectives, * Pregnant or breastfeeding women. * Hospitalized or having undergone surgery within the previous 7 days

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Conditions

The condition(s) this trial relates to.

Inflammation leptospirosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Jarisch herxheimer reaction Leptospirosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.