New vaccine aims to shield babies from pneumonia and meningitis

NCT ID NCT07629440

Vaccine Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 4 times

Summary

This study tests a new pneumococcal vaccine in healthy infants to see if it is safe and works better than the current vaccine. About 3,230 babies will receive either the new vaccine or the existing one at routine checkups. Researchers will compare side effects and immune responses to see if the new vaccine offers broader protection against serious infections like pneumonia and meningitis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: pneumococcal conjugate vaccine (new version)
What this could lead to: If it works, this could provide broader protection against pneumonia, meningitis, and ear infections in infants compared to the current vaccine.
What could go wrong: This is an early Phase 3 trial, so results are not yet known. The new vaccine may not be more effective or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 3,230 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

42 to 211 days

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * infants who are 2 months of age in Group 1. * infants who are 2 to 6 months of age in Groups 2 and 3. * Healthy infants determined by clinical assessment, including medical history and clinical judgment, to be eligible for the study. Exclusion Criteria: * History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis). * Major known congenital malformation or serious chronic disorder. * Other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study. * Previous vaccination with any licensed or investigational pneumococcal vaccine, or planned receipt through study participation.

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Conditions

The condition(s) this trial relates to.

pneumococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumococcal disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

124 sites in 3 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

ACC Pediatric Research
RECRUITING

Haughton, Louisiana, 71037, United States
AMR Clinical
RECRUITING

Provo, Utah, 84604, United States
AMR Clinical
RECRUITING

Syracuse, Utah, 84075, United States
ASR, LLC
RECRUITING

Boise, Idaho, 83702, United States
Aavon Clinical Trials, LLC.
RECRUITING

Houston, Texas, 77074, United States
Advanced Research Center, Inc.
RECRUITING

Anaheim, California, 92805, United States
Alabama Clinical Therapeutics, LLC Birmingham Pediatric Associates
RECRUITING

Birmingham, Alabama, 35205, United States
Allegheny Health and Wellness Pavilion
RECRUITING

Erie, Pennsylvania, 16506, United States
Altruistic Clinical Research Global
RECRUITING

Norcross, Georgia, 30093, United States
Atrium Health - STRIVE Research clinic
RECRUITING

Charlotte, North Carolina, 28207, United States
Atrium Health Cannon Research Cente
RECRUITING

Charlotte, North Carolina, 28203, United States
Atrium Health Levine Children's Charlotte Pediatrics
RECRUITING

Matthews, North Carolina, 28105, United States
Atrium Health Levine Children's Myers Park Pediatrics
RECRUITING

Charlotte, North Carolina, 28207, United States
Atrium Health STRIVE Research Clinic - Matthews
RECRUITING

Matthews, North Carolina, 28105, United States
BRCR Global Puerto Rico
RECRUITING

Ponce, 00728, Puerto Rico
BRCR Global Puerto Rico
RECRUITING

San Juan, 00907, Puerto Rico
Bailony Pediatrics
RECRUITING

National City, California, 91950, United States
Bingham Memorial Hospital
RECRUITING

Blackfoot, Idaho, 83221, United States
Bioresearch Partner
RECRUITING

Miami, Florida, 33155, United States
C & R Research Services USA
RECRUITING

Homestead, Florida, 33030, United States
Caguas Clinical Research
RECRUITING

Caguas, 00725, Puerto Rico
Carolina Family Care
RECRUITING

Summerville, South Carolina, 29486, United States
Child Health Care Associates
RECRUITING

East Syracuse, New York, 13057, United States
Children's Health Center
RECRUITING

Tampa, Florida, 33617, United States
Childrens Hospital of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Clinical Research Investigator Group
RECRUITING

Bayamón, 00960, Puerto Rico
Clinical Research Partners, LLC
RECRUITING

Richmond, Virginia, 23226, United States
Clinical Research Puerto Rico
RECRUITING

Guayama, 00784, Puerto Rico
Clinical Research of Central California
RECRUITING

Fresno, California, 93704, United States
Coast Clinical Research, LLC
RECRUITING

Bellflower, California, 90706, United States
Cordova Research Institute LLC
RECRUITING

Sweetwater, Florida, 33182, United States
Crossroads Clinical Research
NOT_YET_RECRUITING

Victoria, Texas, 77901, United States
Dade Research Center
RECRUITING

Miami, Florida, 33173, United States
Direct Helpers Research Center
RECRUITING

Hialeah, Florida, 33012, United States
Dr. Ruben Aleman & Associates
RECRUITING

McAllen, Texas, 78504, United States
Duke Vaccine and Trials Unit
RECRUITING

Durham, North Carolina, 27703, United States
Durham Pediatrics at North Duke Street
RECRUITING

Durham, North Carolina, 27704, United States
Eminent Clinical Research and Associates
RECRUITING

North Lauderdale, Florida, 33068, United States
Eximia Research - IA, LLC (dba Integrated Clinical Trial Services, LLC)
RECRUITING

West Des Moines, Iowa, 50265, United States
Family Medical Clinic
RECRUITING

El Monte, California, 91731, United States
Florida Pharmaceutical Research and Associates, Inc.
RECRUITING

Miami, Florida, 33143, United States
Fukazawa Pediatric Clinic
RECRUITING

Fukuoka, 813-0036, Japan
Fukui Aiiku Hospital
RECRUITING

Fukui, 910-0833, Japan
Futaba Clinic
RECRUITING

Shinjuku-ku, Tokyo, 160-0017, Japan
Gold Coast Health Research Center, LLC
RECRUITING

Miami, Florida, 33155, United States
Helios Clinical Research
RECRUITING

Sherwood, Arkansas, 72120, United States
Houston Clinical Research Associates
RECRUITING

Houston, Texas, 77090, United States
Integrity Clinical Network, LLC
RECRUITING

Derby, Kansas, 67037, United States
KUR Research, LLC
NOT_YET_RECRUITING

Bessemer, Alabama, 35022, United States
KUR Research, LLC
NOT_YET_RECRUITING

Centreville, Alabama, 35042, United States
Kool Kids Pediatrics
RECRUITING

Houston, Texas, 77065, United States
Kose Children Clinic
RECRUITING

Kofu, Yamanashi, 400-0853, Japan
Kubota Children's Clinic
RECRUITING

Osaka, 544-0033, Japan
Kur Research, LLC
RECRUITING

Columbia, Maryland, 21045, United States
Le Bonheur Children's Hospital - Outpatient Building
NOT_YET_RECRUITING

Memphis, Tennessee, 38105, United States
Leavitt Clinical Research
RECRUITING

Idaho Falls, Idaho, 83404, United States
MUSC Children's Health
RECRUITING

Summerville, South Carolina, 29486, United States
Marshfield Medical Center - Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States
Medical Research Partners
RECRUITING

Ammon, Idaho, 83406, United States
Mercury Clinical Research (Administrative Office)
RECRUITING

Houston, Texas, 77054, United States
Mercury Clinical Research - MD Kids Pediatrics
RECRUITING

Houston, Texas, 77087, United States
Mercury Clinical Research - Sunrise Pediatrics
RECRUITING

Houston, Texas, 77077, United States
Michigan Center of Medical Research
RECRUITING

Bingham Farms, Michigan, 48025, United States
Michigan Institute of Research
RECRUITING

Allen Park, Michigan, 48101, United States
MidValley Research, Inc
RECRUITING

Moline, Illinois, 61265, United States
Midwest Children's Health Research Institute
RECRUITING

Lincoln, Nebraska, 68504, United States
Midwest Children's Health Research Institute
RECRUITING

Lincoln, Nebraska, 68505, United States
Midwest Children's Health Research Institute
RECRUITING

Lincoln, Nebraska, 68516, United States
Midwest Children's Health Research Institute
RECRUITING

Lincoln, Nebraska, 68522, United States
Neutra Life Sciences
RECRUITING

Houston, Texas, 77042, United States
Nintenkaikagoshima Children's Hospital
RECRUITING

Hioki, Kagoshima-ken, 899-2503, Japan
Northwest Arkansas Pediatric Clinic
RECRUITING

Fayetteville, Arkansas, 72703, United States
ObjectiveHealth Clinical Research LLC - Chamblee
NOT_YET_RECRUITING

Chamblee, Georgia, 30341, United States
Ohigesenseino Kodomo Clinic
RECRUITING

Sapporo, Hokkaido, 062-0907, Japan
Pediatric Associates of Mt. Carmel
RECRUITING

Cincinnati, Ohio, 45245, United States
Pediatric Center- Neutra Life Sciences
RECRUITING

Richmond, Texas, 77469, United States
Pediatric Clinical Trials of Tennessee, LLC
RECRUITING

Tullahoma, Tennessee, 37388, United States
Ponce Medical School Foundation Inc./ CAIMED Center
RECRUITING

Ponce, 00716, Puerto Rico
PriMED Clinical Research
RECRUITING

Dayton, Ohio, 45429, United States
Prime Clinical Research - Lewisville
RECRUITING

Lewisville, Texas, 75067, United States
Prime Clinical Research - Mansfield
RECRUITING

Mansfield, Texas, 76063, United States
Proactive Clinical Research LLC
RECRUITING

Edinburg, Texas, 78539, United States
Proactive El Paso,LLC
RECRUITING

El Paso, Texas, 79902, United States
Proactive RGV
RECRUITING

Brownsville, Texas, 78520, United States
RTX Clinical Research
RECRUITING

Houston, Texas, 77074, United States
Riveldi and Associates
RECRUITING

Miami Lakes, Florida, 33014, United States
SMS Clinical Research LLC
RECRUITING

Mesquite, Texas, 75149, United States
SMS Clinical Research LLC
RECRUITING

Mesquite, Texas, 75150, United States
SMS Clinical Research LLC.
RECRUITING

Forney, Texas, 75126, United States
San Gabriel Woman's Health
RECRUITING

Arcadia, California, 91007, United States
San Juan Bautista School of Medicine - Clinical Research Unit
RECRUITING

Caguas, 00726, Puerto Rico
San Miguel Medical
RECRUITING

Trujillo Alto, 00976-3910, Puerto Rico
Senders Pediatrics
RECRUITING

South Euclid, Ohio, 44121, United States
SeraCollection Research Services, LLC
RECRUITING

Montebello, California, 90640, United States
Shindo children's clinic
RECRUITING

Fukuoka, Fukuoka, 814-0121, Japan
South Texas Clinical Research
NOT_YET_RECRUITING

Corpus Christi, Texas, 78404, United States
Stanford University Medical Center
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Sun Research Institute
RECRUITING

San Antonio, Texas, 78215, United States
TOYOTA Memorial Hospital
RECRUITING

Toyota-shi, Aichi-ken, 471-8513, Japan
Tekton Research, LLC.
RECRUITING

Richmond, Virginia, 23233, United States
The Children's Clinic of Jonesboro, P.A.
RECRUITING

Jonesboro, Arkansas, 72401, United States
The Iowa Clinic.
RECRUITING

Ankeny, Iowa, 50023, United States
The Pediatric Center
NOT_YET_RECRUITING

Columbia, Maryland, 21045, United States
Tribe Clinical Research LLC. at Parkside Pediatrics Harrison Bridge Road
RECRUITING

Simpsonville, South Carolina, 29680, United States
UDL Clinical Research, LLC.
NOT_YET_RECRUITING

Houston, Texas, 77057, United States
UPMC Children's Community Pediatrics - Norwin
RECRUITING

N. Huntingdon, Pennsylvania, 15642, United States
UPMC Children's Community Pediatrics Bass Wolfson-Cranberry
RECRUITING

Cranberry Township, Pennsylvania, 16066, United States
UPMC Children's Community Pediatrics Bass Wolfson-Squirrel Hill
RECRUITING

Pittsburgh, Pennsylvania, 15217, United States
UPMC Children's Community Pediatrics South Hills-Jefferson Hills
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States
UPMC Children's Community Pediatrics- Bellevue
RECRUITING

Bellevue, Pennsylvania, 15202, United States
UPMC Children's Community Pediatrics-Brentwood
RECRUITING

Pittsburgh, Pennsylvania, 15227, United States
UPMC Children's Community Pediatrics-Castle Shannon
RECRUITING

Pittsburgh, Pennsylvania, 15234, United States
UPMC Children's Hospital of Pittsburgh Primary Care Center-Oakland
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Alabama at Birmingham - School of Medicine
RECRUITING

Birmingham, Alabama, 35233, United States
University of Maryland, Baltimore, Center for Vaccine Development and Global Health
NOT_YET_RECRUITING

Baltimore, Maryland, 21201, United States
University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States
University of Missouri Pediatrics Clinic-South Providence
RECRUITING

Columbia, Missouri, 65201, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Texas Medical Branch, Sealy Institute for Vaccine Sciences Clinical Trials Program
RECRUITING

Galveston, Texas, 77555, United States
Vasconcello-Cohen MD Research, LLC.
RECRUITING

Miami, Florida, 33183, United States
Velocity Clinical Research, Grand Island
RECRUITING

Grand Island, Nebraska, 68803, United States
Vida Clinical Studies, LLC
RECRUITING

Dearborn Heights, Michigan, 48127, United States
Wilmington Health
RECRUITING

Wilmington, North Carolina, 28405, United States
Yokoyama Children'S Clinic
RECRUITING

Kasuga, Fukuoka, 816-0801, Japan

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