Bacterial infectious disease
MONDO:0005113An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections.
Also known as: Bacteria caused disease or disorder, Bacteria disease or disorder, Bacteria infectious disease, bacterial disease, bacterial disorder, bacterial infection, bacterial infectious disease, infection, bacterial
2073 clinical trials for this condition and its sub-types, 96 tagged with Bacterial infectious disease itself.
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Sub-types of Bacterial infectious disease
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Primary bacterial infectious disease 0 trials · 590 incl. sub-types
37 sub-types
- Tuberculosis 216 trials · 298 incl. sub-types Sub-types →
- Syphilis 47 trials · 56 incl. sub-types Sub-types →
- Gonorrhea 49 trials Sub-types →
- Tetanus 43 trials Sub-types →
- Lyme disease 30 trials
- Diphtheria 27 trials Sub-types →
- Mycobacterium avium complex disease 22 trials
- Anthrax infection 17 trials · 20 incl. sub-types Sub-types →
- Salmonellosis 5 trials · 19 incl. sub-types Sub-types →
- Cholera 16 trials
- Shigellosis 14 trials
- Leprosy 11 trials · 12 incl. sub-types Sub-types →
- Leptospirosis 9 trials Sub-types →
- Botulism 5 trials Sub-types →
- Listeriosis 4 trials Sub-types →
- Plague 2 trials · 4 incl. sub-types Sub-types →
- Buruli ulcer disease 3 trials
- Q fever 3 trials
- Campylobacteriosis 3 trials Sub-types →
- Melioidosis 3 trials
- Brucellosis 2 trials Sub-types →
- Legionellosis 1 trial · 2 incl. sub-types Sub-types →
- Relapsing fever 2 trials Sub-types →
- Bartonellosis 0 trials · 1 incl. sub-types Sub-types →
- Ehrlichiosis 1 trial Sub-types →
- Granuloma inguinale 0 trials · 1 incl. sub-types Sub-types →
- Ornithosis 1 trial
- Pinta disease 1 trial
- Borrelia miyamotoi disease 0 trials
- Chancroid 0 trials
- Glanders 0 trials
- Rhinoscleroma 0 trials
- Sennetsu fever 0 trials
- Spirillary rat-bite fever 0 trials
- Staphyloenterotoxemia 0 trials
- Streptobacillary rat-bite fever 0 trials
- Tularemia 0 trials Sub-types →
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Mycobacterial infectious disease 23 trials · 360 incl. sub-types
7 sub-types
- Tuberculosis 216 trials · 298 incl. sub-types Sub-types →
- Pulmonary non-tuberculous mycobacterial infection 48 trials
- Mycobacterium avium complex disease 22 trials
- Leprosy 11 trials · 12 incl. sub-types Sub-types →
- Buruli ulcer disease 3 trials
- Mycobacterium xenopi infection 2 trials
- Aquarium granuloma 0 trials
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Gram-negative bacterial infections 33 trials · 300 incl. sub-types
15 sub-types
- Helicobacter pylori infectious disease 115 trials
- Treponema infectious disease 6 trials · 57 incl. sub-types Sub-types →
- Chlamydiaceae infections 1 trial · 55 incl. sub-types Sub-types →
- Bordetellosis 0 trials · 39 incl. sub-types Sub-types →
- Moraxellaceae infectious disease 0 trials · 8 incl. sub-types Sub-types →
- Pneumonia caused by gram negative bacteria 5 trials · 7 incl. sub-types Sub-types →
- Rickettsiaceae infectious disease 0 trials · 4 incl. sub-types Sub-types →
- Burkholderia infectious disease 0 trials · 3 incl. sub-types Sub-types →
- Anaplasmataceae infectious disease 0 trials · 2 incl. sub-types Sub-types →
- Bartonellaceae infectious disease 0 trials · 1 incl. sub-types Sub-types →
- Bacteroidaceae infectious disease 0 trials Sub-types →
- Desulfovibrionaceae infectious disease 0 trials
- Fusobacteriaceae infectious disease 0 trials Sub-types →
- Bacterial meningitis caused by gram-negative bacteria 0 trials Sub-types →
- Streptobacillus infectious disease 0 trials Sub-types →
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Commensal bacterial infectious disease 0 trials · 272 incl. sub-types
6 sub-types
- Toxic shock syndrome 224 trials Sub-types →
- Chlamydia trachomatis infectious disease 37 trials · 48 incl. sub-types Sub-types →
- Lemierre syndrome 0 trials
- Actinomycosis 0 trials Sub-types →
- Gas gangrene 0 trials
- Staphylococcal scalded skin syndrome 0 trials
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Gram-positive bacterial infections 7 trials · 251 incl. sub-types
6 sub-types
- Streptococcal infection 19 trials · 131 incl. sub-types Sub-types →
- Clostridium infectious disease 48 trials · 96 incl. sub-types Sub-types →
- Bacillaceae infectious disease 1 trial · 20 incl. sub-types Sub-types →
- Actinomycetales infectious disease 1 trial Sub-types →
- Erysipelothrix infectious disease 0 trials Sub-types →
- Infection caused by Bifidobacterium 0 trials
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Pulpitis 191 trials
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Bacterial infectious disease with sepsis 78 trials · 113 incl. sub-types
5 sub-types
- Neonatal sepsis 35 trials
- Lemierre syndrome 0 trials
- Pasteurella hemorrhagic septicemia 0 trials
- Gas gangrene 0 trials
- Meningococcemia 0 trials
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Bacterial sexually transmitted disease 8 trials · 113 incl. sub-types
5 sub-types
- Treponema infectious disease 6 trials · 57 incl. sub-types Sub-types →
- Chlamydia infectious disease 34 trials · 55 incl. sub-types Sub-types →
- Gonorrhea 49 trials Sub-types →
- Granuloma inguinale 0 trials · 1 incl. sub-types Sub-types →
- Chancroid 0 trials
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Anaerobic bacteria infectious disease 2 trials · 99 incl. sub-types
10 sub-types
- Clostridium infectious disease 48 trials · 96 incl. sub-types Sub-types →
- Actinomycetales infectious disease 1 trial Sub-types →
- Bacteroides infectious disease 0 trials
- Fusobacterium infectious disease 0 trials
- Peptostreptococcus infectious disease 0 trials
- Anaerobic balanitis 0 trials
- Anaerobic cellulitis 0 trials
- Anaerobic meningitis 0 trials
- Anaerobic pneumonia 0 trials
- Infection caused by Bifidobacterium 0 trials
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Spirochaetales infections 1 trial · 97 incl. sub-types
4 sub-types
- Treponema infectious disease 6 trials · 57 incl. sub-types Sub-types →
- Lyme disease 30 trials
- Leptospirosis 9 trials Sub-types →
- Borrelia infectious disease 6 trials · 7 incl. sub-types Sub-types →
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Bacterial arthritis 24 trials · 94 incl. sub-types
6 sub-types
- Periprosthetic joint infection 76 trials
- Escherichia coli discitis 0 trials
- Gonococcal infection of joint 0 trials Sub-types →
- Salmonella discitis 0 trials
- Staphylococcus discitis 0 trials
- Streptococcus pneumoniae discitis 0 trials
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Staphylococcal infection 41 trials · 84 incl. sub-types
4 sub-types
- Staphylococcus aureus infection 37 trials · 69 incl. sub-types Sub-types →
- Staphylococcal pneumonia 1 trial Sub-types →
- Staphylococcal toxemia 0 trials · 1 incl. sub-types Sub-types →
- Staphyloenterotoxemia 0 trials
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Bacterial urinary tract infection 55 trials · 81 incl. sub-types
8 sub-types
- Pyelonephritis 8 trials · 21 incl. sub-types Sub-types →
- Acute cystitis 7 trials Sub-types →
- Urethritis 5 trials · 6 incl. sub-types Sub-types →
- Gonococcal cystitis 0 trials Sub-types →
- Neonatal urinary tract infectious disease 0 trials
- Renal tuberculosis 0 trials
- Ureter tuberculosis 0 trials
- Urinary bladder tuberculosis 0 trials
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Clostridium difficile colitis 69 trials
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Bacterial pneumonia 28 trials · 65 incl. sub-types
8 sub-types
- Streptococcal pneumonia 16 trials
- Mycoplasma pneumoniae pneumonia 9 trials
- Klebsiella pneumonia 7 trials
- Pneumonia caused by gram negative bacteria 5 trials · 7 incl. sub-types Sub-types →
- Pneumonia caused by pseudomonas aeruginosa infection 3 trials
- Legionnaires' disease 2 trials
- Staphylococcal pneumonia 1 trial Sub-types →
- Anaerobic pneumonia 0 trials
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Skin disease caused by bacterial infection 13 trials · 57 incl. sub-types
17 sub-types
- Cellulitis 29 trials · 31 incl. sub-types Sub-types →
- Hordeolum 1 trial · 7 incl. sub-types Sub-types →
- Impetigo 5 trials Sub-types →
- Cutaneous anthrax 2 trials
- Erysipelas 1 trial
- Pinta disease 1 trial
- Aquarium granuloma 0 trials
- Bacillary angiomatosis 0 trials
- Bacterial exanthem 0 trials
- Bullous impetigo 0 trials
- Cutaneous diphtheria 0 trials
- Cutaneous syphilis 0 trials Sub-types →
- Cutaneous tuberculosis 0 trials Sub-types →
- Gas gangrene 0 trials
- Gonococcal keratitis 0 trials
- Staphylococcal scalded skin syndrome 0 trials
- Sycosis barbae 0 trials
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Meningococcal infection 47 trials · 55 incl. sub-types
2 sub-types
- Meningococcal meningitis 18 trials
- Meningococcemia 0 trials
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Bifidobacteriales infectious disease 0 trials · 44 incl. sub-types
2 sub-types
- Bacterial vaginosis 44 trials
- Infection caused by Bifidobacterium 0 trials
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Bacterial meningitis 12 trials · 37 incl. sub-types
8 sub-types
- Meningococcal meningitis 18 trials
- Meningeal tuberculosis 7 trials
- Haemophilus meningitis 1 trial
- Escherichia coli meningitis 0 trials
- Listeria meningitis 0 trials
- Anaerobic meningitis 0 trials
- Bacterial meningitis caused by gram-negative bacteria 0 trials Sub-types →
- Streptococcal meningitis 0 trials Sub-types →
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Pseudomonas infection 25 trials · 29 incl. sub-types
1 sub-type
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Escherichia coli infection 26 trials
1 sub-type
- Escherichia coli discitis 0 trials
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Vibrio infectious disease 0 trials · 16 incl. sub-types
2 sub-types
- Cholera 16 trials
- Vibrio vulnificus infectious disease 0 trials
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Bacterial endocarditis 15 trials
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Mycoplasmoides infection 7 trials · 15 incl. sub-types
2 sub-types
- Mycoplasma pneumoniae pneumonia 9 trials
- Mycoplasma encephalitis 0 trials
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Haemophilus infectious disease 14 trials
2 sub-types
- Haemophilus meningitis 1 trial
- Chancroid 0 trials
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Necrotizing soft tissue infection 13 trials
2 sub-types
- Necrotizing cellulitis 0 trials
- Necrotizing myositis 0 trials
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Empyema 10 trials · 11 incl. sub-types
2 sub-types
- Subdural empyema 1 trial
- Tuberculous empyema 0 trials
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Chorioamnionitis 10 trials
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Klebsiella infectious disease 5 trials · 9 incl. sub-types
3 sub-types
- Klebsiella pneumonia 7 trials
- Granuloma inguinale 0 trials · 1 incl. sub-types Sub-types →
- Rhinoscleroma 0 trials
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Rickettsiosis 2 trials · 7 incl. sub-types
3 sub-types
- Rickettsiaceae infectious disease 0 trials · 4 incl. sub-types Sub-types →
- Anaplasmataceae infectious disease 0 trials · 2 incl. sub-types Sub-types →
- Tick-borne relapsing fever 0 trials
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Tracheitis 2 trials · 7 incl. sub-types
1 sub-type
- Laryngotracheitis 1 trial · 5 incl. sub-types Sub-types →
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Peritonsillar abscess 4 trials
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Enterococcus infectious disease 1 trial · 4 incl. sub-types
1 sub-type
- Enterococcus faecalis infection 3 trials
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Yersinia infectious disease 0 trials · 4 incl. sub-types
3 sub-types
- Plague 2 trials · 4 incl. sub-types Sub-types →
- Yersinia enterocolitica infectious disease 0 trials
- Yersinia pseudotuberculosis infectious disease 0 trials Sub-types →
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Bacterial conjunctivitis 3 trials
3 sub-types
- Gonococcal conjunctivitis 0 trials Sub-types →
- Inclusion conjunctivitis 0 trials
- Pseudomembranous conjunctivitis 0 trials Sub-types →
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Bacterial hemorrhagic fever 0 trials · 3 incl. sub-types
1 sub-type
- Scrub typhus 3 trials
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Bacterial gastritis 2 trials
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Fournier gangrene 2 trials
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Septic peritonitis 2 trials
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Opportunistic bacterial infectious disease 0 trials · 1 incl. sub-types
2 sub-types
- Nocardiosis 1 trial
- Cepacia syndrome 0 trials
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Actinobacillus infectious disease 0 trials
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1 sub-type
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Pectobacterium carotovorum infection 0 trials
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Proteus infectious disease 0 trials
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Whipple disease 0 trials
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Bacterial myositis 0 trials
1 sub-type
- Pyomyositis 0 trials
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Botryomycosis 0 trials
2 sub-types
- Cutaneous botryomycosis 0 trials
- Visceral botryomycosis 0 trials
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Idiopathic severe pneumococcemia 0 trials
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Noma 0 trials
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Pasteurellosis 0 trials
1 sub-type
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Pneumonic pasteurellosis 0 trials
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Rat-bite fever 0 trials
2 sub-types
- Spirillary rat-bite fever 0 trials
- Streptobacillary rat-bite fever 0 trials
Most studied deeper sub-types
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New MenB vaccine trial aims to protect babies to adults
Vaccine Stopped earlyThis early-stage study tested a new meningococcal B vaccine in 576 healthy people, from infants to adults. Researchers checked for side effects and measured immune responses, comparing the new vaccine to two already-approved ones. The goal was to see if the vaccine is safe and tr…
Phase 1 • Sponsor: Sanofi Pasteur, a Sanofi Company • Aim: Vaccine
Last updated Jun 27, 2026 07:54 UTC
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Stool test could replace endoscopy for h. pylori treatment decisions
Disease control Stopped earlyThis study tested whether a simple stool test can guide doctors in choosing the right antibiotics for H. pylori infections, avoiding the need for an invasive stomach camera procedure. The test detects the bacteria and checks for antibiotic resistance, aiming to improve cure rates…
Sponsor: Poitiers University Hospital • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Supercharged immune cells take on Drug-Resistant infections
Disease control Stopped earlyThis trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New hope for recurring c. diff: which treatment works best?
Disease control Stopped earlyThis study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…
Phase 4 • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Personalized antibiotic dosing may boost infection treatment
Disease control Stopped earlyThis study tests whether using personalized dosing (based on drug levels in the blood) for the antibiotic teicoplanin works better than standard dosing for treating bacterial infections. About 74 adults in hospital intensive care or other units will take part. The goal is to see …
Phase 4 • Sponsor: Radboud University Medical Center • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Timing of steroids could save lives in sepsis
Disease control Stopped earlyThis study looks at whether giving steroids very early to patients with severe infections and low blood pressure works better than waiting until standard treatments fail. About 230 adults will be randomly assigned to get either early steroids or a placebo, and neither they nor th…
Sponsor: Siriraj Hospital • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Can a once-weekly antibiotic help people with opioid use disorder beat serious infections at home?
Disease control Stopped earlyThis trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…
Phase 4 • Sponsor: University of Maryland, Baltimore • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Could a 3-Month TB cocktail replace the standard 6-Month regimen?
Disease control Stopped earlyThis clinical trial investigates whether a 3-month combination of clofazimine and rifapentine can effectively treat drug-susceptible tuberculosis (TB) compared to the standard 6-month regimen. The study includes adults with pulmonary TB, some of whom also have HIV. Researchers ar…
Phase 2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Promising c. diff drug fails to prove benefit in small, halted trial
Disease control Stopped earlyThis study tested whether an extra dose of bezlotoxumab, a drug that blocks the harmful toxin made by C. diff bacteria, could help very sick patients recover after emergency colon surgery. Only 5 people took part before the study was stopped early. The goal was to see if the drug…
Phase 4 • Sponsor: Ohio State University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for stubborn lung infection? trial of epetraborole begins, then stops
Disease control Stopped earlyThis study tested an oral drug called epetraborole for people with a tough-to-treat lung infection called MAC lung disease. The trial aimed to see if adding epetraborole to standard treatment could improve symptoms and clear the infection. However, the study was terminated early,…
Phase 2/3 • Sponsor: AN2 Therapeutics, Inc • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Could aspirin or ibuprofen help beat TB faster?
Disease control Stopped earlyThis study tested whether adding aspirin or ibuprofen to standard tuberculosis (TB) treatment helps patients recover more quickly. It included 426 adults with drug-sensitive or drug-resistant TB. The trial was terminated early, so the results are not conclusive.
Phase 2 • Sponsor: Fundació Institut Germans Trias i Pujol • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New TB drug cocktails aim to cut treatment time in half
Disease control Stopped earlyThis clinical trial tested whether combining several drugs—bedaquiline, OPC-167832, sutezolid, and either pretomanid or delamanid—could treat pulmonary tuberculosis in just 2 to 4 months instead of the standard 6 months. The study enrolled 93 adults with drug-sensitive or drug-re…
Phase 2 • Sponsor: Gates Medical Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Tonsil infection showdown: surgery vs. drainage
Disease control Stopped earlyThis study looked at the best way to treat a tonsillar abscess, a painful infection near the tonsils. It compared two treatments: removing the tonsils (tonsillectomy) versus draining the pus with a needle under local anesthesia. The goal was to see which method works better to cl…
Sponsor: University Hospital, Geneva • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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Can cuddling save tiny babies? trial tests early kangaroo care
Disease control Stopped earlyThis study looked at whether starting continuous skin-to-skin contact (kangaroo mother care) within 24 hours of birth helps unstable preterm babies under 2000g survive. It compared this to standard incubator care. The trial took place in The Gambia and enrolled 279 babies, but wa…
Sponsor: London School of Hygiene and Tropical Medicine • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Can a simple urine test prevent kidney failure in sepsis?
Disease control Stopped earlyThis study tested whether using a urine biomarker test (NephroCheck) to guide treatment could reduce kidney injury, dialysis, or death in sepsis patients. The trial planned to enroll many participants but was stopped early after only 19 people joined. The idea was to catch kidney…
Sponsor: BioMérieux • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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New syphilis combo treatment tested in HIV patients – trial cut short
Disease control Stopped earlyThis study looked at two different antibiotic combinations for treating early syphilis in people living with HIV. One group received a single shot of ceftriaxone plus a week of doxycycline pills, while the other got the standard single shot of penicillin plus the same doxycycline…
Phase 4 • Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Timing of dialysis in septic shock: early vs. delayed – study halted early
Disease control Stopped earlyThis study looked at 500 adults with septic shock and severe acute kidney injury to see if starting dialysis early (within 12 hours) or waiting (48-60 hours) affected survival at 90 days. The trial was terminated early, so the results are not conclusive. The goal was to find the …
Phase 3 • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Could a common sedative save lives in septic shock?
Disease control Stopped earlyThis study tested whether a sedative drug called dexmedetomidine could help restore blood pressure control in patients with severe septic shock that does not respond to standard treatments. The trial involved 32 adults in intensive care. The goal was to see if the drug could impr…
Phase 3 • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Rapid test plus targeted antibiotic shows promise for tough infections in blood cancer patients
Disease control Stopped earlyThis study tested whether the antibiotic ceftolozane-tazobactam, guided by a rapid molecular test, could effectively treat serious Pseudomonas aeruginosa infections in people with blood cancers or those who had a stem cell transplant. The 17 participants received the antibiotic t…
Phase 4 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Light therapy for stubborn eyelid lumps? tiny trial ends early
Disease control Stopped earlyThis study tested whether intense pulsed light (IPL) can help treat chalazion, a common eyelid lump. Only 4 adults with a fresh chalazion were enrolled, and the trial was stopped early. Because of the very small size, we cannot say if IPL works or is safe for this condition.
Sponsor: Lumenis Be Ltd. • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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MRSA decolonization kit trial stalls after just one patient
Disease control Stopped earlyThis study tested a complete kit using povidone-iodine (Betadine) gel, soap, and mouthwash to clear MRSA bacteria from patients' noses, skin, and mouths. The goal was to see if the kit could quickly decolonize MRSA within 6 hours. However, the trial was terminated early after enr…
Phase 2 • Sponsor: Nantes University Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Quick test could spare kids from strong antibiotics for UTIs
Disease control Stopped earlyThis study tested whether a rapid lab test (looking for integrons in urine) could help doctors choose a narrow-spectrum antibiotic instead of a broad-spectrum one for children with fever and a urinary tract infection. The goal was to see if this approach works as well as standard…
Sponsor: University Hospital, Limoges • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Promising c. diff drug trial halted after just 3 patients
Disease control Stopped earlyThis study tested a new drug called REC-3964 to see if it could prevent repeat Clostridioides difficile (C. diff) infections in adults. Only 3 people were enrolled before the trial was stopped early. The goal was to check safety and whether the drug helped people stay infection-f…
Phase 2 • Sponsor: Recursion Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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New inhaled drug aimed at stubborn lung infection shows promise, but trial halted early
Disease control Stopped earlyThis phase 3 study tested an inhaled form of the antibiotic clofazimine added to standard therapy for people with MAC lung disease that did not respond to previous treatment. The goal was to see if the drug could clear the infection from sputum cultures and improve quality of lif…
Phase 3 • Sponsor: Mannkind Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Could a pill replace IV drips for septic shock? small trial halted early
Disease control Stopped earlyThis study tested whether the oral drug midodrine could help people with septic shock stop needing IV blood pressure support sooner. The trial planned to enroll many patients but was stopped early with only 10 participants. Because it was so small, we cannot draw firm conclusions…
Phase 3 • Sponsor: University of Virginia • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Antibiotic teicoplanin tested for stubborn gut infection
Disease control Stopped earlyThis study tested the antibiotic teicoplanin (taken by mouth twice daily for 7 to 14 days) in 50 adults hospitalized with C. difficile infection causing diarrhea and colitis. The goal was to see if it could stop diarrhea and prevent it from coming back. The trial was terminated e…
Phase 4 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Bedside eye scans may reveal hidden blood flow problems in septic shock
Diagnosis Stopped earlySepsis and septic shock cause widespread inflammation and organ failure, and problems with the smallest blood vessels may drive worse outcomes. Researchers are testing whether a non-invasive eye imaging technique called optical coherence tomography angiography (OCTA) can detect t…
Sponsor: Hospital da Luz, Portugal • Aim: Diagnosis
Last updated Sep 20, 2026 00:00 UTC
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A single blood draw to unmask hidden infections in immune-weakened patients?
Diagnosis Stopped earlyThis trial tests a new blood test that uses metagenomic sequencing to identify any infection-causing microbe in cancer patients who develop febrile neutropenia—a serious fever that occurs when their immune system is weakened by treatment. The test aims to find the culprit faster …
Sponsor: Poitiers University Hospital • Aim: Diagnosis
Last updated Aug 27, 2026 00:00 UTC
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A simple blood test may spot hidden infections in kids with cancer
Diagnosis Stopped earlyThis pilot study asks whether a blood marker called procalcitonin can help predict bacteremia—a serious bacterial infection in the blood—in children with cancer who develop a fever. Currently, doctors rely on blood cultures, which can take up to 48 hours or give false negatives. …
Sponsor: CAMC Health System • Aim: Diagnosis
Last updated Aug 21, 2026 00:00 UTC
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New device aims to stop deadly infections in tiny preemies
Prevention Stopped earlyThis study tested a special multi-line device (Edelvaiss Multiline NEO) to see if it could prevent bloodstream infections in very premature infants (24-29 weeks) who need IV medications and nutrition. The device was compared to standard infusion sets. Unfortunately, the trial was…
Sponsor: University Hospital, Lille • Aim: Prevention
Last updated Jun 27, 2026 12:23 UTC
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TB prevention study halted early – only 16 volunteers enrolled
Prevention Stopped earlyThis study aimed to see if a single dose of the BCG vaccine could prevent tuberculosis infection in healthy adults traveling to countries with high TB rates. Participants were randomly assigned to receive either BCG or a placebo. The study was terminated early and enrolled only 1…
Phase 3 • Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Pharmacists step in to treat bladder infections in women
Symptom relief Stopped earlyThis study looked at whether a special protocol used by community pharmacists in France can help women with simple bladder infections (cystitis) get relief more quickly. The goal was to reduce symptoms and avoid unnecessary trips to the doctor or emergency room. The study include…
Sponsor: University Hospital, Angers • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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New sedation approach may help septic shock patients breathe on their own sooner
Symptom relief Stopped earlyThis study tested whether a gas sedative (isoflurane) could help patients with septic shock wake up and get off a breathing machine faster than standard IV sedation (midazolam). The goal was to reduce complications from long-term sedation and ventilation. Only one patient was enr…
Phase 4 • Sponsor: University Hospital, Rouen • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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Exercise and diet boost mental health in heart infection patients
Symptom relief Stopped earlyThis study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…
Sponsor: Johannes Grand • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Lyme arthritis pain study halted early – what we know
Symptom relief Stopped earlyThis study aimed to see if taking NSAIDs (like naproxen) on a regular schedule could reduce arthritis symptoms and prevent long-term joint problems in people with Lyme disease. Only 3 participants were enrolled before the study was stopped, so no clear conclusions can be drawn. T…
Phase 3 • Sponsor: Desiree Neville, MD • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Pregnancy drug study aims to protect moms and babies from HIV and TB
Knowledge-focused Stopped earlyThis study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and new mothers. Researchers measured drug levels in the blood of 205 women during pregnancy and after delivery to see if standard doses are effective. The goal was to gat…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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COPD study investigates why patients struggle to fight lung infections
Knowledge-focused Stopped earlyThis study looked at whether a weak immune response to bacteria in COPD patients leads to more lung infections and flare-ups. Researchers collected sputum, blood, and nasal swabs from 23 hospitalized COPD patients during a flare-up and again 8 to 16 weeks later. The goal was to m…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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New X-Ray tech could cut radiation and save time for hip surgery patients
Knowledge-focused Stopped earlyThis study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Scientists hunt for clues to tell infection apart from inflammation in Kids' joints
Knowledge-focused Stopped earlyThis study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Blood pressure experiment in sepsis halted early – kidney protection still unclear
Knowledge-focused Stopped earlyThis study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early an…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Gene hunt: why some people get worse blood infections
Knowledge-focused Stopped earlyThis study looked at whether certain genetic differences in the immune system make some people more likely to develop severe bloodstream infections from E. coli or Staphylococcus aureus bacteria. Researchers planned to analyze blood samples from 60 patients to find mutations link…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Vaccine antibody check: how long does protection last?
Knowledge-focused Stopped earlyThis study followed women who previously received 1 to 3 doses of an experimental Group B Strep (GBS) vaccine. The goal was to see how long their immune antibodies lasted by taking yearly blood samples for 2 to 5 years. No new vaccine or treatment was given—only observation.
Sponsor: Minervax ApS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Blood pressure drug study in septic shock halted early
Knowledge-focused Stopped earlyThis observational study aimed to understand why some septic shock patients respond better to the drug vasopressin. Researchers planned to compare blood markers, heart ultrasound images, and tissue oxygen levels between responders and non-responders. However, the study was termin…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Nose drops with friendly bacteria could pave way for meningitis vaccine
Knowledge-focused Stopped earlyThis study gave healthy adults nose drops containing a harmless bacteria (N. lactamica) to see how the body's immune system responds. The goal is to learn if the immune response is the same whether the bacteria is cleared after 4 days or 14 days. This information will help design…
Sponsor: University Hospital Southampton NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Scientists track HPV's secret life in young women
Knowledge-focused Stopped earlyThis study followed 190 young women to learn how the body handles new HPV infections. Researchers measured virus levels, immune cells, and other factors over time. The goal was to understand why some infections clear quickly while others persist. No treatment was given; this was …
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC