Quick test could spare kids from strong antibiotics for UTIs
NCT ID NCT05066854
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a rapid lab test (looking for integrons in urine) could help doctors choose a narrow-spectrum antibiotic instead of a broad-spectrum one for children with fever and a urinary tract infection. The goal was to see if this approach works as well as standard care while using fewer strong antibiotics. The trial was stopped early and included only 36 children, so the findings are limited.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- integron PCR test to guide antibiotic choice
- What this could lead to
- If successful, this approach could reduce the use of broad-spectrum antibiotics in children with urinary tract infections, helping to slow antibiotic resistance.
- What could go wrong
- The trial was terminated early with only 36 participants, so results are limited. The test may not be accurate enough in all settings, and narrow-spectrum antibiotics might still fail if the bacteria are resistant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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36 people
The number who actually took part.
- Started
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Oct 2022
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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3 months to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children above 3 months old and under 18 years old * Consultation in a participating pediatric emergency department * Suspicion of UTI with fever (Fever ≥ 38°C and urine dipstick test positive for leukocytes and/or nitrites) * First episode of UTI with fever * Written informed consent of the holders of parental authority * Affiliated to Social Security Exclusion Criteria: * Criteria of severity: * Severe infection with severe sepsis or septic shock * Dehydration ≥ 10% * Fever ≥ 38°C \> 4 days (96h) * Indication of surgical or interventional drainage * Complication risk factors: * Any anatomic or functional defect of the urinary tract (other than low-grade VUR and calyceal dilation \< 10 mm) * Repetition of UTI with fever ≤ than 6 months since the previous episode * Repetition of UTI with fever and anatomic or functional defect of the urinary tract * Pregnancy * Severely immunocompromised patient * Severe chronic renal failure defined as a clearance \< 30 mL/min/1.73 m2 * Severe liver failure * 3GC allergy * Contra-indication to SXT: * G6PD deficiency * Treatment with methotrexate * Allergy to sulfonamide * Antibiotic treatment within 48h before admission * Empirical antibiotic treatment not recommended
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bordeaux university Hospital
Bordeaux, 33000, France
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Limoges university Hospital
Limoges, 87042, France
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Montpellier university Hospital
Montpellier, 34000, France
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Toulouse university Hospital
Toulouse, 31000, France
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