Urinary tract infection

This expanded access program lets doctors in Texas give banked, partially matched virus-specific T cells to children under 18 who have persistent or recurring EBV, CMV, adenovirus, or BK virus infections after an allogeneic stem cell transplant or CAR T therapy. The cells come fr…

This study compares two oral treatments for trichomonas, a common sexually transmitted infection. About 1,200 women and men with a positive test will receive either a single dose of secnidazole or multiple doses of metronidazole over several days. The goal is to see which approac…

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. Researchers will check safety and immune response in 448 adults aged 18-64, and then see if it works in women of the same age. Participants receive either the vaccine or…

This study tests a new treatment called LBP-EC01, which uses specially designed viruses (bacteriophages) to attack drug-resistant E. coli bacteria that cause urinary tract infections (UTIs). About 318 adults with a history of UTIs and a current infection will receive either LBP-E…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This phase 2 trial is investigating how a combination of two antibiotics, cefepime and enmetazobactam, is processed by the body and whether it is safe and tolerable in children from birth to under 18 years old who are hospitalized with a complicated urinary tract infection (cUTI)…

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenous…

This early-phase trial is testing whether immune cells called R-MVST cells, grown quickly from a healthy donor, can safely fight off stubborn viral infections (EBV, CMV, adenovirus, or BK virus) in children and young adults with weakened immune systems. Participants have not resp…

This study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This study tests a new cell therapy called LB-DTK-MV in children aged 1-25 who have stubborn viral infections (CMV, EBV, or BKV) after a stem cell transplant. The therapy uses specially grown immune cells from a donor to attack the viruses. Participants receive two infusions two …

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This early-phase trial tests a treatment called LB-DTK-MV, which uses immune cells from a healthy donor to fight three viruses (CMV, BKV, and EBV) that have become resistant to standard antiviral drugs. The study includes 27 adults who have had a stem cell transplant or certain c…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study tests whether using an antibiotic (gentamicin) in the irrigation fluid and a special suction tube during kidney stone surgery can lower the chance of fever, inflammation, or sepsis afterward. About 180 adults having this surgery will be randomly assigned to receive one…

This study tests whether a bladder wash with a low-dose antiseptic (chlorhexidine) during routine catheter changes can reduce urinary tract infections and unplanned healthcare visits. Seventy adults with a long-term suprapubic catheter and a history of UTIs will receive the wash …

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it red…

This early-stage trial tests whether specially grown immune cells from a donor can safely help transplant patients fight off viral infections that standard treatments can't control. The cells target Epstein-Barr virus, cytomegalovirus, adenovirus, and BK virus. Up to 36 adults wh…

This study tests whether reducing anti-rejection drugs, with or without an extra treatment called IVIG, can better control BK virus in kidney transplant patients. BK virus can damage the new kidney and lead to transplant failure. About 280 adults and children who have a kidney or…

This study tests whether specially grown immune cells (called cytotoxic T lymphocytes) can safely lower BK virus levels in 20 transplant patients with weakened immune systems. Participants have had a stem cell or kidney transplant and show signs of BK virus infection. The goal is…

This study tests whether a simple technique called double voiding—urinating twice in one bathroom visit—can reduce urinary tract infections (UTIs) in kidney transplant recipients. UTIs are common after transplant and can lead to serious complications. The trial will compare doubl…

This study tests whether taking a short course of antibiotics (ciprofloxacin) after Botox injections into the bladder can reduce the chance of urinary tract infections. About 160 adults with neurogenic overactive bladder (due to conditions like multiple sclerosis or spinal cord i…

This study tests whether tinidazole, a drug already approved for other infections, can cure Mycoplasma genitalium in men with urethritis. About 40 men will take the medication and be checked 21 days later to see if the bacteria are gone. The goal is to find a new treatment option…

This study tests whether adding hydrogen peroxide fogging or ultraviolet light to regular cleaning can reduce infections in intensive care units. Over 5,000 adult patients in 12 Brazilian ICUs will take part. Each ICU will try all three methods (standard cleaning, cleaning plus h…

This study tests whether specially grown immune cells (BK-specific cytotoxic T-cells) from a related donor can safely lower BK virus levels in children, teens, and young adults. Participants have BK infections that did not get better with standard treatment, often after a stem ce…

This study provides a fecal transplant product made from healthy donor stool to treat people with recurrent Clostridium difficile infection or multidrug-resistant urinary tract infections. The product is delivered by courier or FedEx after a contract is signed. The goal is to res…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This 6-month study tests whether a daily D-Mannose drink mix (FLUSH) can help women with a history of recurrent UTIs have fewer infections and better urinary health. About 210 adult women will be randomly assigned to one of three groups. Researchers will track how long it takes f…

This study compares two ways to prevent cytomegalovirus (CMV) infection in kidney transplant patients who already carry the virus. One approach gives antiviral drugs to everyone for 3 months, while the other uses immune system tests to decide who needs treatment. The goal is to s…

This study compares two antibiotic treatments for acute kidney infection in children aged 1 month to 3 years. One group gets 3 days of IV antibiotics only, while the other gets 3 days IV followed by 7 days of oral antibiotics. The goal is to see if the shorter course works just a…

This early-stage study tests whether a harmless bacterium called Lactobacillus crispatus, when placed directly into the bladder, is safe and can help prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. Forty participants will receive two …

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care…

This early-phase trial tests the safety and tolerability of a new antibiotic called JKN2501 in 66 healthy adults in China. Participants receive either the drug or a placebo by IV infusion, and researchers monitor for side effects and how the drug moves through the body. The goal …

This study compares two ways to prevent repeat urinary tract infections (UTIs) in women after menopause. One group takes a nightly antibiotic pill for 6 months, while the other uses a vaginal tablet containing a probiotic (Lactobacillus) and a tiny amount of estrogen. The goal is…

This study tests whether taking the antibiotic ciprofloxacin for three days after bladder Botox injections reduces the risk of urinary tract infections in women with overactive bladder. About 202 women will be randomly assigned to receive either the antibiotic or a placebo pill. …

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study compares a new DNA-based test (PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. About 136 people with UTI symptoms will be randomly assigned to one of the two tests. Researchers will track how quickly treatment starts, how sy…

This study tests whether next-generation sequencing (NGS), a DNA-based method, can detect bacteria in urine when standard lab cultures show very low or no growth. About 100 women with UTI symptoms but inconclusive standard tests will provide urine samples for NGS analysis. The go…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study looks at whether giving women a single dose of antibiotics right before a clinic-based urethral bulking procedure (for stress incontinence) can lower their chance of getting a urinary tract infection afterward. About 150 women will be split into two groups: one gets th…

This trial tests whether methenamine hippurate, a non-antibiotic antiseptic, can prevent urinary tract infections (UTIs) as effectively as standard antibiotics in women receiving BOTOX-A injections for overactive bladder. Participants will be randomly assigned to take either meth…

This pilot study tests whether applying a steroid cream to the foreskin for four weeks can prevent recurrent urinary tract infections (UTIs) in uncircumcised male infants under 6 months who have had their first fever-related UTI. Forty infants will receive either the steroid crea…

This study tests whether rinsing the bladder with Irrisept (a chlorhexidine solution) before removing a urinary catheter can prevent infections better than rinsing with salt water. Researchers will compare infection rates and antibiotic use in 300 adults. The goal is to find a no…

This study tests whether taking a daily vitamin C pill for 10 days can prevent catheter-associated urinary tract infections in women having elective gynecologic surgery. Half of the 180 participants will receive vitamin C, and half will receive a placebo. The goal is to see if th…

This study tests a vaginal gel called Multi-Gyn UT Protect to see if it can prevent repeated urinary tract infections (UTIs) in women. Fifty adult women who have had multiple UTIs in the past year but no current infection will apply the gel twice a week for four months. Researche…

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This phase 3 trial tests whether the drug U101 (pentosan polysulfate sodium) can prevent recurrent urinary tract infections (UTIs) in women aged 20 to 75. About 348 women with a history of frequent UTIs will take either U101 or a placebo daily for 24 weeks. Researchers will track…

This study tests whether washing the bladder with a harmless strain of E. coli can prevent recurrent urinary tract infections (UTIs) in people who have failed other treatments. Researchers will compare the harmless bacteria wash to a saltwater wash in 80 participants, tracking ho…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study compares two ways to clean the area before placing a temporary bladder catheter: Betadine (the current standard) versus sterile water. Researchers want to see if sterile water leads to fewer bacteria in the urine and less pain during the procedure. About 148 adults who…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study looks at whether standing in the shower instead of sitting on the toilet helps women urinate more easily after having a catheter removed following vaginal surgery. The goal is to see if this position reduces pain, lowers the amount of urine left in the bladder, and dec…

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study tests whether a short animated video and flyer, available in English and Spanish, can help patients collect cleaner urine samples. Contaminated samples often lead to wrong diagnoses and unnecessary antibiotics, which fuels antibiotic resistance. About 252 adults in pri…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study looks at whether taking antibiotics before a procedure to treat stress urinary incontinence (leaking urine with cough or sneeze) can lower the chance of getting a urinary tract infection (UTI) afterward. About 138 women will receive either antibiotics or a placebo befo…

Complicated urinary tract infections are hard to treat and often return, and doctors need better data on what drives treatment failure. This observational study follows thousands of patients with confirmed complicated UTIs across multiple sites, collecting information on their sy…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study will include 2,600 adults scheduled for bladder tumor surgery. Half will get a standard urine culture before surgery; the other half will not. The goal is to see if skipping the test leads to more fevers or infections in the month after surgery. If it's safe, it could …

This study looks at how doctors can improve antibiotic prescriptions for urinary tract infections (UTIs) after patients leave the emergency department. Researchers will check if adjusting antibiotics based on lab test results reduces the use of strong drugs like fluoroquinolones.…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This registry study is collecting blood and urine samples from 60 kidney transplant recipients who have BK virus infection. Researchers want to understand how the immune system responds to the virus and how immunosuppressive drugs affect that response. The goal is to find better …

This study tests whether point-of-care STI tests, which give results in about 10 minutes, can speed up treatment for pregnant women compared to standard lab tests. About 756 pregnant women at Grady Memorial Hospital will either get the rapid tests or standard testing. The goal is…

This study collects urine samples from adults who use intermittent catheters, both during urinary tract infections (UTIs) and during symptom-free periods. The goal is to explore basic urine characteristics, like bacterial counts, to better understand UTIs in this group. No treatm…

This study follows 400 adults who receive a Double-J ureteral stent—a tube that helps drain urine from the kidney to the bladder. The goal is to identify risk factors for bacteria sticking to the stent and to see how this colonization relates to urinary tract infections, antibiot…

This study looks at how hyperbaric oxygen therapy (HBOT) affects symptoms and urine markers in people with chronic radiation cystitis, a bladder condition caused by past radiation treatment. Researchers will collect urine, blood, and tissue samples from 100 participants before, d…

This study tests a prediction model to help doctors decide if antibiotics are really needed for urinary tract infections (UTIs) in the emergency room. About 47 women with UTIs will be enrolled. The goal is to reduce unnecessary antibiotic use and fight antibiotic resistance.

This study looks at 100 kidney transplant patients to understand where the BK virus comes from and why some people get sicker than others. Researchers will compare the virus in patients and their donors, and check how the immune system responds. The goal is to find better ways to…

This study collects anonymous symptom descriptions from 1,000 adults through an online platform. An AI tool then searches medical literature to see if it can find reliable biological signals in the free-text descriptions. The goal is to test how accurate and consistent the AI's f…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study creates a global registry to collect information from 200 people with hantavirus infections. Researchers will track how the disease spreads, its symptoms, and what treatments doctors use. No new treatments are tested; the goal is to gather knowledge to improve future c…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…