Urinary tract infection

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study tests whether a machine-learning system called iAST® can improve how doctors choose antibiotics for patients with pneumonia, urinary tract infections, or sepsis. The AI predicts which antibiotics are likely to work before standard lab results are available. Researchers…

This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibio…

This study tests whether giving a daily antibiotic (pivmecillinam) to kidney transplant patients at high risk of bloodstream infections can reduce those infections. 150 participants will receive either the antibiotic or a placebo for 5 months after transplant. The goal is to see …

This early-stage trial is testing an experimental antibiotic called TUL108 in healthy volunteers to see if it is safe and how the body processes it. The drug is being developed for complicated urinary tract infections (cUTI), which can be difficult to treat with standard antibiot…

This study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…

This study tests whether a new drug called AIC263029 is safe and can lower BK virus levels in kidney transplant recipients. About 24 adults who had a kidney transplant within the past year and have a first-time BK virus infection will receive weekly injections for 4 weeks. Resear…

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This lab study tests whether chitosan nanoparticles—made from shrimp shells—can break down the sticky biofilms that protect E. coli bacteria in urinary tract infections. Researchers will collect bacteria from 60 patients and treat them with chitosan alone or with the antibiotic c…

This early study tests whether adding vitamin C to the drug methenamine hippurate (Hiprex) helps prevent recurrent urinary tract infections (UTIs) in women. Twenty women will take either Hiprex alone or Hiprex plus vitamin C for six months each, and researchers will compare how m…

This study tests a special gelled water (GEL-AID) in nursing home residents aged 65 and older. The goal is to see if it helps them drink more fluids, preventing dehydration, urinary infections, and respiratory infections. One group gets the usual hydration plan, while the other g…

This early study tests whether a personalized mix of viruses (called phages) can safely treat urinary tract infections caused by drug-resistant bacteria. Six adults aged 18–65 will receive the phage cocktail through a catheter every 12 hours for 2–3 days. Researchers will monitor…

This trial is testing a new rapid urine test called Jiddu that aims to quickly identify urinary tract infections (UTIs) and determine which antibiotics will work best. The study involves 100 adults with neurogenic bladder who use catheters and suspect they have a UTI. Participant…

This study is testing whether new biomarkers in urine can more accurately diagnose urinary tract infections (UTIs) in two groups where current tests often fail: young children not yet toilet-trained and adults aged 65 and older. In these groups, standard urine tests can be mislea…

This trial tests three ways to manage urinary symptoms in women aged 65 and older who have frequent urinary tract infections. Some participants receive antibiotics right away, while others get treatment only after a urine test or a lab culture. The goal is to find out which appro…

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. T…

This study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.

This study looks at whether taking the antibiotic TMP-SMX for a full year after a kidney transplant can prevent urinary tract infections (UTIs) better than stopping after 6 months. Fifty children and young adults who recently had a kidney transplant will either keep taking TMP-SM…

This study tests whether electroacupuncture can prevent recurrent lower urinary tract infections in women. Over 300 participants will receive either real or sham electroacupuncture for 6 months, tracking infection episodes and antibiotic use. The goal is to see if this needle-bas…

This study tests whether rinsing the kidney with an antibiotic called dioxidine right after stone-removal surgery can stop infection-related stones from returning. About 95 adults with infection-type kidney stones will get either standard surgery alone or surgery plus the rinse. …

This study looks at whether a personalized exercise program, started in the hospital and continued at home with video supervision, can help older adults recover after being hospitalized for pneumonia or a urinary tract infection. The goal is to see if this approach is safe, impro…

This study tests whether potassium citrate, a medication that makes urine less acidic, can relieve painful UTI symptoms in women aged 18-50. Fifty participants will take either potassium citrate or the antibiotic nitrofurantoin for 7 days. Researchers will compare symptom scores …

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study is creating and testing two new patient-reported tools to measure recurrent urinary tract infection (UTI) symptoms. One is a daily symptom diary for adults, and the other is adapted specifically for people aged 65 and older. About 200 participants with recurrent UTIs w…

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study measures how much of the antibiotic gepotidacin passes into breast milk after a single 3000 mg dose. Eight healthy lactating women will provide milk and blood samples over 72 hours. The goal is to understand drug exposure for nursing infants, which could guide future u…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study will follow 1000 kidney transplant patients for one year to see if monthly blood tests for certain viruses (CMV, BK, and TTV) can help predict and prevent serious infections and kidney damage. The goal is to learn how the body's immune system and virus levels relate to…

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study looks at whether a special program can help doctors stop ordering unnecessary urine tests for patients before surgery. The program will be tested at six VA hospitals over two years. Researchers will track how many tests are done and if this reduces the use of antibioti…

This study tracks BK virus in saliva, urine, and blood of 100 kidney transplant recipients over one year. The goal is to see if the virus spreads through saliva and how it affects the new kidney. Participants collect their own saliva samples at home, plus give urine and blood at …

This study looks at why some people with a rare virus called hantavirus develop serious bleeding and kidney failure. Researchers will study blood samples from 62 hospitalized patients in Slovenia to understand how clotting goes wrong. The goal is to better predict who is at risk …

This study examines the impact of removing urine dipstick tests for diagnosing urinary tract infections (UTIs) in hospitals in the North Denmark Region. Researchers will compare data from before and after the change, looking at UTI diagnoses, antibiotic use, lab tests, and patien…

This study looks at a little-known bacteria called Providencia that can cause urinary tract infections (UTIs). Researchers will collect samples from 241 patients to identify the germ, test which antibiotics work against it, and look for genes that make it resistant to drugs. The …

This study looks at how receiving positive urine culture results impacts stress levels and bladder symptoms in women with recurrent urinary tract infections (UTIs). Researchers will follow 170 women, including those with interstitial cystitis or bladder pain syndrome, using quest…

This study looks at whether teaching patients about catheter care can improve their attitudes toward preventing infections and lower their anxiety after urologic surgery. About 70 male patients who go home with a urinary catheter will receive a training booklet based on daily liv…