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New drug aims to stop CMV from coming back after transplant

NCT ID NCT06407232

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 23 times

Summary

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it reduces the number of CMV flare-ups and the need for other treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UW Hospital and Clinics

    RECRUITING

    Madison, Wisconsin, 53792, United States

    Contact

    Contact

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Letermovir (Prevymis)

What this could lead to

If successful, letermovir could offer a new way to prevent CMV from coming back after treatment in transplant patients, reducing the need for other antiviral drugs.

What could go wrong

This is a phase 3 trial with only 90 participants, so results may not apply to everyone. Letermovir may not work as well as hoped, and side effects are possible.

Conditions

The condition(s) this trial relates to.

cytomegalovirus infection pyelonephritis renal infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.