Rapid test plus targeted antibiotic shows promise for tough infections in blood cancer patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligibility Criteria Inclusion Criteria * Presence of a hematologic malignancy or a history of hematopoietic stem cell transplantation * Identification of Pseudomonas aeruginosa by rapid molecular diagnostic testing from a positive blood culture or from a respiratory sample in the setting of radiologically documented pneumonia with compatible clinical symptoms * Age 18 years or older * Ability of the participant or legally authorized representative to provide informed consent Exclusion Criteria * Receipt of more than 72 hours of non-study anti pseudomonal therapy for the infection being treated * Known anaphylactic hypersensitivity or allergic reaction to cephalosporins * History of a Pseudomonas aeruginosa isolate with a ceftolozane or tazobactam MIC greater than 4 micrograms per milliliter * Polymicrobial aerobic Gram negative infection, as determined by the infectious diseases research team * Hemodialysis, continuous renal replacement therapy, or creatinine clearance less than 15 milliliters per minute * Expected mortality within 48 hours of screening Eligibility Criteria for Historical Controls Inclusion Criteria * Presence of a hematologic malignancy or a history of hematopoietic stem cell transplantation * Identification of Pseudomonas aeruginosa associated with bacteremia and or pneumonia * Age 18 years or older * Survival greater than 48 hours after initiation of anti pseudomonal therapy for Pseudomonas aeruginosa bacteremia and or pneumonia Exclusion Criteria * Known anaphylactic hypersensitivity or allergic reaction to cephalosporins * History of a Pseudomonas aeruginosa isolate with a ceftolozane or tazobactam MIC greater than 4 micrograms per milliliter * Polymicrobial aerobic Gram negative infection, as determined by the infectious diseases research team * Hemodialysis, continuous renal replacement therapy, or creatinine clearance less than 15 milliliters per minute