HEMATOLOGIC MALIGNANCY

This early-phase study tests whether adding abatacept to standard drugs can safely prevent graft-versus-host disease (GVHD) after a special stem cell transplant (omidubicel) for blood cancers. Ten adults will receive the drug combination and be monitored for side effects and tran…

This study tests a new way to prepare donor stem cells for transplant in people with blood cancers like leukemia. By removing certain immune cells from the donated cells, researchers hope to lower the risk of graft-versus-host disease, a serious side effect. The study involves 70…

This study tests a new treatment called QH101 for people with blood cancers or solid tumors that have not responded to standard therapy. QH101 uses specially engineered immune cells to better recognize and kill cancer cells while avoiding burnout. The trial aims to see if it is s…

This early-stage study tests a new drug called ziftomenib combined with standard treatments for people with a type of acute myeloid leukemia (AML) that has come back or not responded to therapy. The main goal is to check safety and find the best dose. About 171 adults with specif…

This study tests whether the antifungal drug posaconazole can better prevent serious fungal infections in blood cancer patients who have received a stem cell transplant. These patients are at high risk because their immune systems are weak. The study will check drug levels in the…

This study tests whether a single drug (cyclophosphamide) given after a stem cell transplant can prevent graft-versus-host disease (GVHD) as well as standard multiple-drug approaches. About 82 adults with blood cancers will receive one of two conditioning regimens before transpla…

This early-phase study tests whether it is safe and possible to collect a patient's own blood stem cells and give them together with CAR-T cell therapy for people with blood cancers that have come back or not responded to treatment. About 20 adults aged 18 to 85 with certain type…

This study tests a new way to do stem cell transplants for children and young adults with high-risk blood cancers. The approach uses specially selected immune cells from a half-matched donor to lower the risk of serious side effects like graft-versus-host disease. Up to 30 partic…

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (CD19+ ALL). It uses a special type of immune cell (CAR T cells) after a transplant from a partially matched family donor. The goal is to see if this combination is safe and…

This study compares different lengths of maribavir treatment for CMV infection that doesn't respond to standard therapy in adults who had a stem cell transplant. About 218 participants will receive maribavir for either a shorter or longer period to see which better prevents the i…

This study tests a stem cell transplant using a half-matched family donor for people with blood cancers. The goal is to see if this method helps the body accept the new cells and control the cancer. About 20 adults will receive a mild chemotherapy and radiation treatment before t…

This early-stage study tests whether adding two drugs, decitabine and venetoclax, to a standard stem cell transplant can make the procedure safer for people with aggressive blood cancers like leukemia. About 20 adults aged 18-75 with a matched donor will receive the experimental …

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil alongside their usual GVHD prevention medicine…

This study tests whether injecting special immune-building cells (HTLPs) after a cord blood transplant helps adults with blood cancers rebuild their immune system faster. About 10 participants will receive the injection and be monitored for side effects like graft-versus-host dis…

This study tests whether combining two drugs, pirtobrutinib and venetoclax, can help control mantle cell lymphoma (MCL) that has returned or not responded to prior therapy. About 30 adults with confirmed MCL will take both pills by mouth. The goal is to see how many patients' tum…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help blood cancer patients sleep better and manage fatigue, stress, and pain. About 60 adults with blood cancers like leukemia or lymphoma will either get the program or standard care. The program…

This study tests whether combining a ketogenic diet supplement with online brain training can improve thinking skills in blood cancer survivors. About 80 adults with mild to moderate memory or focus problems will be randomly assigned to either start the program right away or wait…

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients getting a stem cell transplant. The program focuses on improving quality of life and managing symptoms during treatment. About 40 adults will take part to see if the pr…

This study looks at whether a 12-week home exercise program with remote coaching and monitoring can improve heart and lung fitness and daily activity levels in people who have finished treatment for lymphoma. About 80 participants will be randomly assigned to either the home-base…

This study looks at whether giving blood transfusions at home is practical and acceptable for people with blood cancers or bone marrow failure who need regular transfusions. About 30 adults will receive 1-5 blood product units at home, and researchers will track how often transfu…

This study compares two oral medications—diosmin-hesperidin (a plant-based supplement) and loratadine (an allergy pill)—to see which better prevents severe bone pain caused by G-CSF, a drug that boosts white blood cells in blood cancer patients. About 88 adults receiving G-CSF fo…

This study tests a special support program (BMT-CARE) for people caring for a loved one undergoing a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life and reduces their stress. About 800 caregivers will take part, and their well-be…

This study tests a program that gives blood cancer patients access to blood transfusions at home while in hospice care. The goal is to see if this improves quality of life, mood, and reduces hospital visits near the end of life. About 700 adults with advanced blood cancers like l…

This study looks at whether an online expressive writing workshop can improve mental wellness in young adults (ages 18-39) with blood cancer. Participants will attend a four-week workshop and complete three surveys over 12 weeks. The goal is to see if writing about their feelings…

This study looks at whether adding palliative care (extra support for symptoms and stress) to usual cancer care can improve quality of life for adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to e…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use the headset or receive standard care. The goal is to see if this simple, drug-free appro…

This study looks at how the body processes venetoclax when the tablets are crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured.…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. About 60 youth and their parents will try the tool and report how easy and helpfu…

This study is a worldwide registry that will follow 5,000 adults with breast cancer, blood cancers, or those on certain immune therapies. Its goal is to collect data on patients' health, treatments, and heart events to better understand and predict heart problems caused by cancer…

This study tracks how a stem cell transplant changes the way the body processes medications. Researchers will collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which samples best reflect the patient's own drug-metabolizing genes. The goal is t…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how strong their immune response is after vaccination. They will take blood samples at different times to measure antibodies and T-cells. The goal is to learn if the vac…

This study looks at whether safely removing a reported beta-lactam (like penicillin) allergy label can improve antibiotic use in people with blood cancers. About 3,800 hospitalized patients will take part. The goal is to see if this approach leads to better antibiotic choices and…

This study looks at how energy use in cancer and immune cells changes the bone marrow environment and affects treatment success in blood cancers. Researchers will collect samples from 350 adults with certain blood cancers and healthy donors to measure metabolites, lipids, and gen…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will use ultrasound to check heart function in 60 patients before and a few days after treatment. The goal is to find out how often these heart is…

This study is collecting blood samples from 1,500 cancer patients who are receiving FDA-approved immunotherapy. Researchers will analyze immune-related markers in the blood to see if they can predict whether the treatment will work. The goal is to better understand why some patie…

This study is creating 3D mini-tumors (organoids) from bone marrow samples of 70 people with blood cancers. The goal is to test different chemotherapy combinations on these organoids to see which works best for each person. This approach aims to provide personalized treatment gui…

This study follows 100 children and young adults who have received CAR T-cell therapy to learn about short- and long-term side effects. Researchers will track how often patients get infections, have delays in blood cell recovery, or experience nerve damage. The goal is to better …

This study looks at blood samples from 50 people with blood cancers who are receiving CAR T therapy. Researchers want to understand why the cancer sometimes comes back or doesn't respond to treatment. They will measure immune cells and genetic changes over time to find patterns l…