HEMATOLOGIC MALIGNANCY

This early-stage study is testing whether it is safe and practical to collect a patient's own blood-forming stem cells and give them alongside CAR-T cell therapy. The goal is to see if this combination helps patients with aggressive blood cancers that have returned or stopped res…

This study is testing a new type of CAR T-cell therapy for children and young adults (up to age 21) whose blood cancers have come back or haven't responded to standard treatments. The main goal is to find the safest and most effective dose of these specially engineered immune cel…

This study is testing whether taking two oral medications, pirtobrutinib and venetoclax, together can help control mantle cell lymphoma that has come back or stopped responding to other treatments. It will enroll about 30 adults whose cancer has relapsed or is resistant to therap…

This early-stage study is testing whether adding an experimental drug called ziftomenib to standard leukemia treatments is safe and tolerable for patients. It focuses on adults with acute myeloid leukemia that has returned or not responded to prior therapy and has specific geneti…

This study is testing whether adding a drug called belumosudil to standard treatments can better prevent graft-versus-host disease (GVHD) in blood cancer patients who receive stem cell transplants. Researchers want to see if this approach helps patients live longer without GVHD o…

This early-stage study is testing a new cell injection called HTLP. The goal is to see if it can safely help the immune system rebuild itself faster in adults with blood cancers who receive a cord blood transplant. Faster immune recovery could lower the risk of serious infections…

This early-stage trial is testing the safety of a new type of blood cell transplant for children and young adults (up to age 21) with high-risk blood cancers. The treatment uses specially processed cells from a partially matched family donor, followed by an infusion of immune cel…

This early study is testing if a drug called Darzalex Faspro can safely lower harmful antibodies in patients with blood cancers. Lowering these antibodies may allow patients who are currently ineligible to receive a potentially life-saving stem cell transplant from a donor. The s…

This study is testing a new two-step treatment for children and young adults with a specific type of leukemia or lymphoma that has come back or hasn't responded to other treatments. First, patients receive a stem cell transplant from a partially matched family donor. Then, they r…

This trial is testing a modified bone marrow transplant procedure for people with blood cancers. It's designed for patients who need a transplant but only have a partially matched family donor. The study will see if using a lower-intensity preparation treatment before the transpl…

This study is testing a new way to prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the patient's body after a stem cell transplant for blood cancer. Researchers want to see if a short, intense course of two drugs (cyclophosphamide …

This early-stage study is testing whether a three-drug combination is safe and practical for preventing graft-versus-host disease (GVHD) after a specific type of stem cell transplant for blood cancers. The transplant uses specially processed cord blood cells. Researchers will enr…

This early-stage trial is testing if adding two anti-cancer drugs, decitabine and venetoclax, to a standard stem cell transplant procedure is safe for adults with high-risk blood cancers like acute myeloid leukemia (AML). The main goal is to find the safest dose and see if this c…

This study is testing whether a special PET scan can detect very early signs of heart inflammation in cancer patients taking immunotherapy drugs. Researchers want to see if this scan can identify patients at risk before they develop serious heart problems. The study involves 30 a…

This study aims to find out if a drug called posaconazole is given at a high enough dose to prevent serious fungal infections in patients who have received a stem cell transplant. It will enroll 30 adult patients with blood cancers who are at high risk for these infections. Resea…

This study is testing whether two common oral medications can prevent severe bone pain caused by G-CSF, a drug given to boost white blood cells in people with blood cancers. Researchers are comparing a flavonoid supplement (diosmin-hesperidin) and an allergy medication (loratadin…

This study is testing whether a 12-week home exercise program with remote guidance from a coach helps lymphoma survivors improve their fitness and quality of life better than standard center-based training. It will involve 80 people who have recently finished cancer treatment. Re…

This study is testing a psychological support program called BMT-CARE to see if it improves the quality of life for caregivers of patients undergoing a bone marrow transplant for blood cancer. About 800 caregivers and their patients will be randomly assigned to receive either the…

This study is testing whether a mindfulness-based program can help adults with blood cancer who are struggling with poor sleep during and after a hospital stay. The program includes a mobile app with meditation and sleep tips during hospitalization, followed by video therapy sess…

This study is testing a new hospice care program that provides blood transfusions at home for patients with advanced blood cancers. The goal is to see if this program improves patients' quality of life and mood, and helps more people choose hospice care, compared to the usual sta…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help reduce the pain and anxiety patients feel. It will involve 160 adults with or suspected of having blood cancers who are scheduled for this outpatient procedure. Researchers will com…

This study is testing whether cancer patients with low blood counts can safely receive blood transfusions at home instead of at the hospital. Researchers will enroll 30 patients who regularly need blood transfusions and give them 1-5 transfusions at home. The main goal is to see …

This study is testing if a special diet drink and online brain games can help blood cancer survivors who are struggling with memory and thinking. For 12 weeks, one group will use both the diet drink and the games, while another group waits. Researchers want to see if this combina…

This study aims to understand why some cancer patients respond well to immunotherapy while others don't. Researchers will analyze blood samples from 1,500 cancer patients receiving FDA-approved immunotherapies like pembrolizumab or nivolumab. By examining immune system markers be…

This study aims to understand how children's bodies process a liquid form of the cancer drug venetoclax, which is made by crushing tablets. It involves 30 children and young adults with blood cancers who cannot swallow pills and are already receiving this liquid medicine as part …

This study aims to understand why some patients' blood cancers relapse or become resistant after CAR T therapy, a powerful cell-based treatment. Researchers will track 50 patients over time, analyzing their blood to see if specific immune system patterns can predict if and when t…

This study aims to understand how stem cell transplants affect how patients process medications. Researchers will collect DNA samples from adults with blood cancers before and after transplant to determine the best source for genetic testing. The goal is to improve medication dos…

This research study aims to understand how energy production in cancer cells and immune cells affects treatment resistance and outcomes in blood cancers like leukemia. Researchers will analyze blood and bone marrow samples from 350 patients with various blood cancers to identify …

This study aims to learn about the long-term side effects of CAR-T cell therapy in children and young adults with cancer. Researchers will follow 100 participants for up to two years to track how often they get serious infections, have slow blood count recovery, or experience las…

This study aims to create 3D models from patients' bone marrow samples to test how different chemotherapy combinations affect blood cancer cells. Researchers will grow these 'mini-tumors' in the lab and expose them to various drug combinations to see which ones kill cancer cells …

This study is testing a new family communication tool called 'Let's Get REAL' to help children and teenagers be more involved in decisions about their stem cell or cellular therapy treatments. Researchers will work with 24 young patients (ages 8-17) and their parents to see if th…

This study aims to understand how well the seasonal flu vaccine protects children being treated for blood cancers like leukemia. Researchers will follow 150 young patients for a year, taking small blood samples to measure their immune response after vaccination. The goal is to se…

This study aims to understand if CAR-T cell therapy, a powerful new cancer treatment, might affect heart function in the first few days after patients receive it. Researchers will follow 60 patients with blood cancers, performing heart ultrasounds before and shortly after their C…