HEMATOLOGIC MALIGNANCY

This study is testing a new way to do stem cell transplants for children with blood cancers or bone marrow disorders. Instead of needing a perfectly matched donor, doctors use a partially matched family donor and remove certain immune cells from the donated cells to reduce the ri…

This early-phase study tests whether giving healthy donor natural killer (NK) cells along with two drugs (vactosertib and IL-2) is safe and helps the cells stay active in people with advanced colorectal, stomach/esophageal, or blood cancers. The NK cells are meant to attack cance…

This study tests whether replacing a standard immune-suppressing drug with tocilizumab can prevent stem cell transplant failure and graft-versus-host disease in people with blood cancers. About 21 participants receive a haplo-cord transplant, where stem cells from a half-matched …

This study tests whether a blood test that measures CMV-specific immunity can help doctors decide how long to use the antiviral drug letermovir after a stem cell transplant. The goal is to prevent late-onset CMV infection, a common complication. The trial involves 250 adults rece…

This study tests a program called PATH-C, which uses positive psychology exercises (like gratitude and kindness) to help caregivers of stem cell transplant patients. About 80 adult caregivers will try the program and report on their well-being, quality of life, and physical activ…

This study tests whether benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The drug works by lowering eosinophil levels in the blood. About 51 adults with solid tumors or blood cancers who have moderate to severe skin reactions are…

This study tests a mobile app (CARE app) designed to support caregivers of people receiving a bone marrow transplant for blood cancer. The goal is to see if the app improves caregivers' quality of life and reduces stress. About 120 adult caregivers are taking part, and their well…

This study tracks 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. The goal is to watch for long-term side effects and safety issues over 15 years. No new treatment is given—just regular check-ups to see how patients are doing.…

This study looks at whether older adults with cancer (age 65+) can use computer surveys to report their health and daily living needs. Researchers tested two different computer methods to see if they are reliable and easy to use. The goal is to make it simpler for doctors to asse…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. No extra procedures are d…

This study follows people who previously received an experimental CAR-T cell therapy from AvenCell for cancers like lymphoma, leukemia, or prostate cancer. The goal is to track long-term side effects, including new cancers, nerve problems, or immune disorders. About 178 participa…