Hematologic malignancy

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

After an allogeneic stem cell transplant, patients often face weeks with dangerously low platelets and need frequent transfusions. This trial tests whether romiplostim, a drug that stimulates platelet production, helps platelets recover faster. Researchers randomly assign 87 adul…

This trial tests a care package called the 'WARNING Pack' for people aged 75 and older with cancer. The pack helps doctors spot early signs of age-related problems and provides a guide for managing them. The goal is to prevent a decline in quality of life and reduce the risk of g…

This early study tests an experimental cell therapy called MegaLT, made from umbilical cord blood cells, to help restore platelet levels faster after a cord blood transplant. Adults with blood cancers who receive a cord blood transplant will get a single infusion of MegaLT two we…

This trial tests whether giving patients a special type of donor immune cell, called CD45RA-depleted DLI, can prevent serious viral infections after a stem cell transplant. The study includes 30 high-risk patients who have received a transplant for blood cancer. Researchers will …

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14 to 50 and measure if their menstrual cycles return naturally within six month…

This study tests whether the RSV vaccine Abrysvo can help blood cancer patients who have had a stem cell transplant or CAR-T therapy build immunity against RSV. Researchers will measure antibody levels before and after vaccination in 30 adults. The goal is to see if the vaccine t…

This study tests whether a personalized program of exercise, education, and support before a stem cell transplant can improve strength, reduce frailty, and enhance quality of life in adults with blood cancer. About 68 participants will be randomly assigned to either the prehabili…

This pilot study will test whether an iPad app called DCog Short can spot early signs of brain-related side effects (neurotoxicity) in 40 adults receiving CAR-T cell therapy for blood cancers. Participants will use the app to self-report symptoms, and researchers will compare the…

This phase II trial tests whether adding axatilimab to standard care can prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the recipient's body after a stem cell transplant. Adults with blood cancers receiving a myeloablative allogen…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This study tests whether using an immersive virtual reality headset during exercise can improve motivation, adherence, and emotional well-being in adults undergoing cell therapy or stem cell transplant. Participants follow a therapeutic exercise program with or without VR. The tr…

Researchers at Assiut University are studying adults with blood cancers who receive an autologous hematopoietic stem cell transplant, a procedure that uses a patient's own stem cells. The study follows 123 participants to measure survival, progression-free survival, complications…

This pilot study is testing whether wearable patch monitors can help detect heart problems early in adults undergoing treatment for breast cancer, blood cancers, or multiple myeloma. Participants will wear two patches—one that tracks heart rhythm continuously and another that rec…

This study looks at how the age of a stem cell donor affects outcomes for people with blood cancers. Researchers will analyze data from 5,000 patients who received a first stem cell transplant, comparing those who got cells from younger versus older donors. The goal is to provide…

This study aims to create a score that uses a special blood test to predict bleeding risk in people with blood cancers and very low platelet counts. Researchers will take an extra blood sample from 410 participants and analyze it with viscoelastometric tests. The goal is to ident…

This study will check how common parasitic infections are in 285 people with blood disorders, like anemia or blood cancers, at Assiut University hospitals in Egypt. Researchers will test for Toxoplasma and other parasites. The goal is to understand if routine screening could help…

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This observational study follows 162 patients with blood cancers who are receiving either a stem cell transplant or CAR-T therapy. Researchers will use a questionnaire to measure how symptoms and quality of life change from the start of hospital stay to discharge. The goal is to …

This study aims to adapt a questionnaire called PROFFIT, originally developed in Italy, to measure financial toxicity (the financial burden of cancer treatment) in Turkish patients. Researchers will enroll 320 adults with cancer who have received treatment in the last three month…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…