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Tiny probe to track antibiotics in knee joint after infection surgery

NCT ID NCT07299565

Knowledge-focused Sponsor: University Hospital, Bonn Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses a technique called microdialysis to measure antibiotic levels inside the knee joint after surgery for a knee replacement infection. Researchers will place a tiny probe in the joint to collect fluid samples during the hospital stay (about 14 days). They want to see how local antibiotic levels relate to infection recurrence and overall recovery over 12 months. The study involves 30 adults undergoing two-stage revision surgery for an infected knee replacement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antibiotic-containing cement spacer (gentamicin and vancomycin)
What this could lead to
If successful, this could help doctors better understand how antibiotics work in the joint after surgery, potentially leading to improved treatment protocols for knee infections.
What could go wrong
This is a small, early observational study with only 30 participants. It is not testing a new treatment, so it may not directly lead to better outcomes for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

30 patients over 18 years of age presenting with PJI after total knee arthroplasty and indication for prosthesis explantation and temporary spacer implantation

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * clinical indication for two-stage revision of knee PJI * approval for surgery by the orthopedic and anesthesiologic department * being over 18 years of age * written, informed consent after detailed patient information about the study protocol and possible study dependent risks Exclusion Criteria: * known allergies to antibiotics gentamicin and vancomycin used within the spacer

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Conditions

The condition(s) this trial relates to.

Infections periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periprosthetic knee infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital Bonn

    RECRUITING

    Bonn, North Rhine-Westphalia, 53127, Germany

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