Could a 1-Month pill course stop TB in schools?

NCT ID NCT06022146

Disease control Sponsor: Huashan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study tests whether a 4-week course of two TB drugs works as well as the standard 3-month course to prevent active TB in students and staff who have been exposed. About 3,520 people from schools will take either the short or standard regimen. The goal is to see if the shorter option is easier to complete and just as effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: isoniazid and rifapentine
What this could lead to: If successful, this could offer a shorter, easier TB prevention option for teens and young adults, potentially increasing the number of people who complete treatment.
What could go wrong: This is a large phase 3 trial, but the shorter regimen may still cause side effects or be less effective than the standard 3-month course. Results may not apply outside school settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 3,520 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged ≥13 years and body weight ≥ 30 kg; 2. School-registered individuals including: * Currently attending junior / senior high school or university students; * School staff members; 3. Close contacts of active pulmonary TB index cases (confirmed or clinically diagnosed) within the school, defined by meeting both of the following: * Teachers/students sharing the same classroom or dormitory with the index case; * Exposure history: Prolonged sharing of enclosed space (\>4 hours total within 1 week) with the index case; 4. Confirmed LTBI status through screening; 5. Voluntary participation with signed informed consent form (for adults ≥18 years); 6. Parental / guardian consent and co-signed informed consent form (for minors aged 13-17 years). Exclusion Criteria: 1. Current active TB disease (clinically or bacteriologically confirmed); 2. Documented isoniazid/rifampicin resistance in the corresponding M. tuberculosis strain from the index case; 3. Self-reported use of rifamycins (e.g., rifampicin, rifapentine) or isoniazid for \>14 consecutive days within the past 2 years; 4. Prior completion of full-course of treatment for ATB or LTBI; 5. Hypersensitivity or intolerance to rifamycins (rifapentine / rifampicin) or isoniazid; 6. HIV positive serostatus or AIDS patients; 7. History of viral hepatitis (e.g., chronic hepatitis B, chronic hepatitis C) or liver cirrhosis; 8. Liver dysfunction (TBil\>2.5mg/dL \[43umol/L\] or ALT / AST\>2ULN) or renal dysfunction. 9. Current receiving immunosuppressive therapy or biological agents. 10. Hematologic disorders with either PLT\<50×109/L or WBC\<3.0×109/L. 11. Other conditions deemed unsuitable for TPT by investigators.

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Conditions

The condition(s) this trial relates to.

latent tuberculosis infection tuberculosis active tuberculosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Latent tuberculosis Tuberculosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

66 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

3rd People's Hospital of Bijie
RECRUITING

Bijie, China
Chinese Medicine Hospital of Qingzhen
RECRUITING

Guiyang, China
Dalian Public Health Clinical Center
RECRUITING

Dalian, Liaoning, China
First People's Hospital of Fuquan
RECRUITING

Qiannan, Guizhou, China
First People's Hospital of Kaili
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
Guiyang Public Health Treatment Center
RECRUITING

Guiyang, Guizhou, China
Guizhou Aerospace Hospital
RECRUITING

Zunyi, Guizhou, China
Huashan Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Liuzhi Special District
RECRUITING

Liupanshui, Guizhou, China
People's Hospital of Baiyun District
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Bozhou District
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Cengong
RECRUITING

Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
People's Hospital of Changshun
RECRUITING

Qiannan, China
People's Hospital of Chishui
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Congjiang
RECRUITING

Qiandongnan Miao and Dong Autonomous Prefecture, Guizhou, China
People's Hospital of Dafang Town
RECRUITING

Bijie, China
People's Hospital of Danzhai
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Daozhen Klau and Hmong autonomous county
RECRUITING

Daozhen Klau and Hmong Autonomous County in Zun'yi, Guizhou, China
People's Hospital of Fenggang
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Guanling
RECRUITING

Anshun, Guizhou, China
People's Hospital of Hezhang
RECRUITING

Bijie, Guizhou, China
People's Hospital of Honghuagang District
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Huangping
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Huaxi District
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Jianhe
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Jinping
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Kaiyang
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Leishan
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Libo
RECRUITING

Qiannan, Guizhou, China
People's Hospital of Liping
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Luodian
RECRUITING

Qiannan, Guizhou, China
People's Hospital of Majiang
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, China
People's Hospital of Meitan
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Nayong
RECRUITING

Bijie, China
People's Hospital of Panzhou
RECRUITING

Liupanshui, Guizhou, China
People's Hospital of Pingba District
RECRUITING

Anshun, Guizhou, China
People's Hospital of Puding
RECRUITING

Anshun, Guizhou, China
People's Hospital of Qianxi
RECRUITING

Bijie, Guizhou, China
People's Hospital of Qianxi
RECRUITING

Bijie, Guizhou, China
People's Hospital of Renhuai
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Rongjiang
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Sansui
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Shibing
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Shuicheng District, Liupanshui City
RECRUITING

Liupanshui, Guizhou, China
People's Hospital of Suiyang
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Taijiang
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, China
People's Hospital of Tianzhu
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Tongzi
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Wanshan District
RECRUITING

Tongren, Guizhou, China
People's Hospital of Weining
RECRUITING

Bijie, Guizhou, China
People's Hospital of Wuchuan Klau and Hmong autonomous county
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Wudang District
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Xifeng
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Xishui
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Xiuwen
RECRUITING

Guiyang, Guizhou, China
People's Hospital of Xixiu District
RECRUITING

Anshun, Guizhou, China
People's Hospital of Yuqing
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Zhengan
RECRUITING

Zunyi, Guizhou, China
People's Hospital of Zhenning
RECRUITING

Anshun, Guizhou, China
People's Hospital of Zhenyuan
RECRUITING

Qiandongnan Miao and Dong Autonomous Region, Guizhou, China
People's Hospital of Zhijin
RECRUITING

Bijie, Guizhou, China
People's Hospital of Ziyun
RECRUITING

Anshun, Guiyang, China
Second People's Hospital of Liupanshui City
RECRUITING

Liupanshui, Guizhou, China
Third People's Hospital of Liupanshui
RECRUITING

Liupanshui, Guizhou, China
Zunyi Infectious Disease Hospital
RECRUITING

Zunyi, Guizhou, China
Zunyi Infectious Disease Hospital
RECRUITING

Zunyi, Guizhou, China

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