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Swiss study aims to crack the code on joint infection cures

NCT ID NCT07473089

Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and improve future care for patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify the best surgical and antibiotic treatments to cure joint replacement infections more often.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test a new cure. Results may take years and might not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 329 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2022

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants who undergo revision surgery of a prosthetic hip, knee, shoulder, ankle, or elbow joint for suspected periprosthetic joint infection.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years of age * Revision surgery of any large prosthetic joint (i.e., hip, knee, shoulder, ankle, or elbow) performed for a suspected or confirmed periprosthetic joint infections at any of the participating study centres. This includes patients who were previously treated at another hospital and referred to a participating study centre if data on a transferred patient from the previous institution are available, complete, and archived in the institutional patient information system, and the patient underwent at least one surgery at a participating institution. * Obtained written informed consent * Periprosthetic joint infections diagnosis likely or confirmed according to European Bone and Joint Infection Society criteria Exclusion Criteria: * Documented objection to subsequent use of personal health data * Patient follow-up outside of Switzerland * Diagnosis "periprosthetic joint infections unlikely" according to European Bone and Joint Infection Society criteria

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Conditions

The condition(s) this trial relates to.

Infections nosocomial infection periprosthetic joint infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection as complication of medical care Joint (knee or hip replacement)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau

    RECRUITING

    Aarau, Switzerland

  • Department of Infectious Diseases, Bern University Hospital

    RECRUITING

    Bern, Switzerland

  • Department of Medicine, HFR Fribourg-Hôpital Cantonal

    RECRUITING

    Fribourg, Switzerland

  • Department of Medicine, Lausanne University Hospital

    RECRUITING

    Lausanne, Switzerland

  • Orthopedic Surgery Service, Geneva University Hospitals

    RECRUITING

    Geneva, Switzerland

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