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Can you get the pneumonia shot while sick? new study finds out

NCT ID NCT06822907

Vaccine Sponsor: Centre Hospitalier Universitaire de Saint Etienne Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving the 20-valent pneumococcal vaccine (PCV-20) to adults while they have a fever is as effective and safe as waiting until they are well. About 1052 adults with certain health risks (like heart or lung disease) will take part. The goal is to see if vaccinating during an illness can help more people get protected against serious pneumonia infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 1,052 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria : * History of body temperature ≥ 38°C measured at least twice prior to randomization (Randomization must be performed as soon as possible on a febrile patient or 72 hours after apyrexia at the latest) * Having at least one comorbidity that defines patients as medium or high risk for pneumococcal invasive infection: * Medium risk: Cyanogenic congenital heart disease; chronic heart failure; chronic respiratory failure; chronic obstructive pulmonary disease; emphysema; severe asthma under chronic treatment; chronic renal failure; chronic liver disease; diabetes mellitus treated; Osteo-meningeal leak or cochlear implant; Age \> 65 years old. * High risk : Hypo or asplenic people; hereditary immunodeficiency syndromes; people living with HIV; solid organ transplanted; People under immunosuppressors (corticosteroids, biotherapy) for an auto-immune or an inflammatory chronic disease; patients with nephrotic syndrome * Hospitalization for \> 24 hours long * Social security affiliation * Signed informed consent Exclusion criteria : * Patient unable to give informed consent * Curators, wardship * History of previous vaccination with PCV-7 or PCV-13 or PCV-20 * History of PPV-23 in the previous year * Patient having received another vaccination within one month prior to inclusion or planning another vaccination in the month after inclusion except for Influenza vaccine. * Patient with history of bone marrow transplantation * Patient with haematological malignancies * Patient under chemotherapy for solid tumor or with a history of chemotherapy in the past three months * Patient treated with Rituximab currently or in the past 6 months * Patient with Sequential Organ Failure Assessment (qSOFA ) score ≥ 2 at randomization (acute severe febrile illness) * Patient hospitalized in an Intensive Care Unit * Pregnancy * Breastfeeding woman * Recipients of polyclonal gammaglobulins in the past three months * Inability to follow the protocol * Bleeding disorder contra-indicating intramuscular injection according to the investigator * History of allergy to PCV-20 or vaccine-related components. * S. pneumoniae infection with laboratory confirmation (blood culture, culture from a sterile site, urinary or Cerebrospinal fluid antigens, sputum culture with \> 10\^7 colony forming unit (CFU)/mL) being the cause of the current hospitalization

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Conditions

The condition(s) this trial relates to.

Infections pneumococcal infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute febrile illness Pneumococcal infections

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    24 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assistance Publique Hopitaux de Paris

    NOT_YET_RECRUITING

    Paris, 75679, France

  • CHU de Saint-Etienne

    RECRUITING

    Saint-Etienne, France, 42055, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Annecy, 74000, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Bordeaux, 33000, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Brest, 29609, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    La Roche-sur-Yon, 85925, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Le Puy-en-Velay, 43000, France

  • Centre Hospitalier Bichat

    NOT_YET_RECRUITING

    Paris, 75012, France

  • Centre Hospitalier General

    NOT_YET_RECRUITING

    Le Mans, 72000, France

  • Centre Hospitalier General Metropole Savoie

    NOT_YET_RECRUITING

    Chambéry, 73011, France

  • Centre Hospitalier Regional Universitaire

    NOT_YET_RECRUITING

    Montpellier, 34295, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Besançon, 25000, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Brest, 29609, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Dijon, 21000, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Grenoble, 38043, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Lille, 59037, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Nancy, 54511, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Nantes, 44093, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Nice, 06202, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Nîmes, 30029, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Rennes, 35000, France

  • Centre Hospitalier Universitaire

    NOT_YET_RECRUITING

    Rouen, 76000, France

  • Centre Hospitalier de Creteil

    NOT_YET_RECRUITING

    Créteil, 94000, France

  • Hospices Civils de Lyon

    NOT_YET_RECRUITING

    Lyon, 69004, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.