Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Natural prebiotic could beat antibiotics for thrush and BV

NCT ID NCT05434104

Disease control Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the other half gets standard oral antibiotics. The goal is to see if women find lactoferrin acceptable and if it works well enough to justify a larger future trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lactoferrin vaginal pessaries
What this could lead to
If it works, this could offer women a natural, antibiotic-free option for treating common vaginal infections, reducing side effects and antibiotic resistance.
What could go wrong
This is a small feasibility study, not a large trial. Lactoferrin may not work as well as standard antibiotics, and infections could return.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 16-49 years * Having periods (apart from women with a Mirena IUCD or polycystic ovary syndrome) * Ability to consent * Clinical diagnosis of BV or thrush confirmed on Gram stain * Willing to be randomised to vaginal lactoferrin pessaries or oral antibiotics/antifungals * Agrees to provide vaginal samples at home and post/deliver them back to the research team. * Agrees to avoid douching during the study (as this can flush out lactobacilli needed for a healthy microbiome). Exclusion Criteria: * Pregnant or breast feeding * Currently has chlamydia, gonorrhoea or trichomonas (as treatment for these would affect the results). * Known allergy to metronidazole or azoles * Post-menopausal (because of diagnostic confusion between atrophic vaginitis and bacterial vaginosis)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Bacterial vaginosis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bacterial vaginosis vulvovaginal candidiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bacterial vaginosis Candida vaginal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Guy's and St Thomas' Sexual Health Clinic

    RECRUITING

    London, United Kingdom

  • St Thomas' NHS Trust

    NOT_YET_RECRUITING

    London, se1 7eh, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.