Could a Parent's nose bacteria fix a Child's microbiome after antibiotics?
NCT ID NCT06805994
First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 2 times
Summary
This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished antibiotic treatment. Researchers will measure changes in the child's nasal bacteria after the transplant to see if it helps restore diversity.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nasal microbiota transplant (NMT)
- What this could lead to
- If it works, this could point toward a way to restore healthy nasal bacteria in children after antibiotic treatment, potentially reducing staph infections.
- What could go wrong
- This is a very early Phase 1 study, so it is not yet known if the transplant is safe or effective. The main goal is just to measure changes in nasal bacteria, not to treat disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 175 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2025
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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0 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Child: Inclusion criteria 1. Child has had a prior nasal surveillance culture grow S. aurues 2. Child is \<18 years of age 3. Child completed treatment with intranasal mupirocin for S. aureus nasal colonization as part of routine clinical care two or more days before the planned transplant 4. Child has anticipated hospital length of stay \>3 days after completing intranasal mupirocin treatment 5. Infant \>25 weeks gestation unless \>2 months chronological age Exclusion criteria 1. Child is a ward of the State 2. Child with a diagnosis of immunodeficiency or antenatal suspicion for immunodeficiency (e.g., sibling with known immunodeficiency, genetic syndrome with known associated immunodeficiency) 3. Child cannot have nasal swabs collected (due to anatomic or other clinical intervention, including nasal packing) Donor: Inclusion criteria 1. Donor is able to provide informed consent 2. Donor has a relationship with the child outside of the hospital setting (i.e., not an ICU caregiver) Exclusion criteria 1. Donor had positive COVID-19 test in prior 21 days 2. Donor with signs or symptoms of respiratory illness (e.g. runny nose, congestion, fever, cough) 3. Donor has been in close contact with someone in the last 7 days who had a respiratory viral infection (e.g., cold, flu) 4. Donor tests positive on baseline screening test for S. aureus nasal colonization. 5. Donor tests positive on baseline screening test for a respiratory pathogen. 6. Donor is not able to provide written informed consent 7. Donor is not able to be present at the bedside at the time of intervention. 8. Donor has history of chronic sinusitis, cystic fibrosis, or an infection with a multi-drug resistant organism. 9. Inability or unwillingness to complete the Donor questionnaire or a positive response to any question on the Donor questionnaire. 10. Donor has smoked within the last month
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21287, United States
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