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Could a Parent's nose bacteria fix a Child's microbiome after antibiotics?

NCT ID NCT06805994

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This early study tests whether transferring nasal bacteria from a parent to a child can restore the child's nasal microbiome after they have been treated with antibiotics for staph bacteria. The study involves 175 children who have had staph in their nose and recently finished antibiotic treatment. Researchers will measure changes in the child's nasal bacteria after the transplant to see if it helps restore diversity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nasal microbiota transplant (NMT)
What this could lead to
If it works, this could point toward a way to restore healthy nasal bacteria in children after antibiotic treatment, potentially reducing staph infections.
What could go wrong
This is a very early Phase 1 study, so it is not yet known if the transplant is safe or effective. The main goal is just to measure changes in nasal bacteria, not to treat disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 175 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

0 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Child: Inclusion criteria 1. Child has had a prior nasal surveillance culture grow S. aurues 2. Child is \<18 years of age 3. Child completed treatment with intranasal mupirocin for S. aureus nasal colonization as part of routine clinical care two or more days before the planned transplant 4. Child has anticipated hospital length of stay \>3 days after completing intranasal mupirocin treatment 5. Infant \>25 weeks gestation unless \>2 months chronological age Exclusion criteria 1. Child is a ward of the State 2. Child with a diagnosis of immunodeficiency or antenatal suspicion for immunodeficiency (e.g., sibling with known immunodeficiency, genetic syndrome with known associated immunodeficiency) 3. Child cannot have nasal swabs collected (due to anatomic or other clinical intervention, including nasal packing) Donor: Inclusion criteria 1. Donor is able to provide informed consent 2. Donor has a relationship with the child outside of the hospital setting (i.e., not an ICU caregiver) Exclusion criteria 1. Donor had positive COVID-19 test in prior 21 days 2. Donor with signs or symptoms of respiratory illness (e.g. runny nose, congestion, fever, cough) 3. Donor has been in close contact with someone in the last 7 days who had a respiratory viral infection (e.g., cold, flu) 4. Donor tests positive on baseline screening test for S. aureus nasal colonization. 5. Donor tests positive on baseline screening test for a respiratory pathogen. 6. Donor is not able to provide written informed consent 7. Donor is not able to be present at the bedside at the time of intervention. 8. Donor has history of chronic sinusitis, cystic fibrosis, or an infection with a multi-drug resistant organism. 9. Inability or unwillingness to complete the Donor questionnaire or a positive response to any question on the Donor questionnaire. 10. Donor has smoked within the last month

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Johns Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

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