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Massive meningitis study aims to improve care in brazil

NCT ID NCT07027475

Knowledge-focused Sponsor: Hospital Israelita Albert Einstein Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study is tracking how adults with meningitis are treated in about 30 hospitals across Brazil. Researchers will follow 624 patients during their hospital stay and after discharge to see what treatments work best and how patients recover. The goal is to gather real-world evidence to improve national care guidelines for meningitis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could provide real-world data to improve national guidelines for treating meningitis in adults.
What could go wrong
This is an observational registry, not a treatment trial, so it won't directly test a new therapy. Results may not apply outside Brazil.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 624 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult, ≥ 18 years old, suspect acute meningitis infection

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Both sexes, aged ≥ 18 years, meeting one or more of the criteria (A, B or C) below: --\> Criterion A: Clinical presentation compatible with a suspected case of meningitis or meningococcal disease: Fever ≥ 37.8 °C (axillary) associated with at least two of the following: * Severe headache * Vomiting * Altered level of consciousness (confusion, drowsiness, irritability) * Photophobia * Seizure OR Fever associated with one of the classic signs of meningeal irritation (neck stiffness, Kernig or Brudzinski signs) OR Sudden-onset fever with petechial rash or hemorrhagic suffusions * Criterion B: Cerebrospinal fluid with leukocytes ≥ 5 cells/mm³ (corrected for red blood cell count at 1:500) * Criterion C: Confirmed etiological diagnosis of meningitis or meningococcal disease with no more than 48 hours between pathogen confirmation and signature of the informed consent form by the participant or legal representative. Exclusion criteria * Refusal to provide consent for the study. * Presence of a neurological condition, other than meningitis, that accounts for the current clinical picture. * Clinical, laboratory or radiological evidence of an alternative infectious focus that accounts for the current clinical picture. * Use of an intraventricular device prior to study inclusion. * Etiological diagnosis of meningitis or meningococcal disease confirmed more than 48 hours earlier.

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Conditions

The condition(s) this trial relates to.

bacterial meningitis fungal meningitis infectious meningitis meningitis viral meningitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bacterial meningitis Fungal meningitis Meningitis Viral meningitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Municipal Dr Moysés Deutsch - M'Boi Mirim

    RECRUITING

    São Paulo, 04905020, Brazil

  • Hospital Santa Marcelina

    RECRUITING

    São Paulo, 08270-070, Brazil

  • Hospital São Vicente de Paulo

    RECRUITING

    Passo Fundo, Rio Grande do Sul, 99010-080, Brazil

  • Hospital Universitário Walter Cantídio

    ACTIVE_NOT_RECRUITING

    Fortaleza, Ceará, Brazil

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP

    RECRUITING

    Ribeirão Preto, São Paulo, 14051-140, Brazil

  • Hospitalar Moinhos de Vento

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90560-032, Brazil

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