Scientists probe how meningitis vaccines spark immunity

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants must meet the following conditions in order to be enrolled: * Between 30 and 70 years of age inclusive; * Willing and able to give informed consent for participation after the nature of the study has been explained; * In good health as determined by: medical history history-directed physical examination clinical judgment of the investigator * Able (in the Investigators opinion) and willing to comply with all study requirements including be available for all the visits scheduled in the study; * Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study. Exclusion Criteria: Participants with any of the following conditions or characteristics will be excluded from study enrolment: * Prior receipt of a meningococcal vaccine; * Prior laboratory confirmed disease caused by N meningitides; * Prior history of any anaphylactic shock, asthma, urticarial or other allergic reaction after previous vaccinations or known hypersensitivity to any vaccine component; * Known or suspected autoimmune disease or impairment /alteration of immune function resulting from (for example): * Receipt of immunostimulants * Congenital or acquired immunodeficiency, or receipt of immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding year or long-term systemic corticosteroid therapy (prednisolone or equivalent for more than two consecutive weeks within the past 3 months). * Suspected or known HIV infection or HIV related disease; * Receipt of blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation in the past 3 months * Known bleeding diathesis, or any condition that may be associated with a prolonged bleeding time; * Any condition, which, in the opinion of the investigator, might interfere with the evaluation of the study objectives; * Participation in another clinical trial investigating a vaccine, a drug, a medical device, or a medical procedure; * Pregnancy as confirmed by a positive pregnancy test ; * Concurrent breast-feeding.