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Oral vs. needle: which stops Kids' seizures faster?

NCT ID NCT07626255

Symptom relief Sponsor: Pakistan Air Force (PAF) Hospital Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving midazolam in the mouth (buccal) works as well as a shot in the thigh (intramuscular) to stop seizures in children aged 6 months to 12 years. 90 children were randomly assigned to one of the two methods. The main goal was to see if seizures stopped within 5 minutes. The results could help make seizure treatment easier and less painful for kids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
midazolam
What this could lead to
If buccal midazolam works as well or better than a shot, it could offer a simpler, less painful way to stop seizures in children.
What could go wrong
This is a small, single-hospital study (90 children) with a quasi-experimental design, so results may not apply broadly. The main risk is that seizures may not stop within 5 minutes with either method.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

90 people

The number who actually took part.

Started

Jan 2022

Finished

Jun 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 months to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Children of age 6 months to 12 years, both genders, presenting with seizures (as per operational definition) 2. Children with Seizure disorder, Febrile fits, Meningitis without raised intracranial pressure. Exclusion Criteria: 1. Children with cardiac arrest or hemodynamic instability at presentation, head trauma or drowning. 2. Diagnosed cases of metabolic disorders, CKD. 3. Diagnosed case of raised ICP.

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Conditions

The condition(s) this trial relates to.

epilepsy epilepsy with generalized tonic-clonic seizures febrile seizures, familial meningitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Seizure disorder generalized tonic clonic

Contacts and locations

Locations

  • PAF Hospital Islamabad

    Islamabad, Capital, 44000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.