Could less Anti-Rejection medicine save kidney transplant patients in the ICU?

This study looks at whether reducing the dose of anti-rejection drugs (immunosuppressants) can help kidney transplant patients recover faster from life-threatening infections like septic shock or severe breathing failure in the intensive care unit (ICU). About 212 adult kidney transplant recipients who are at least 3 months post-transplant and admitted to the ICU for these conditions will be randomly assigned to either a reduced or standard immunosuppression regimen. The goal is to see if lowering these drugs improves overall organ function without increasing the risk of rejecting the transplanted kidney.