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Blood pressure tweaks may predict kidney outcomes in septic shock

NCT ID NCT04281277

Knowledge-focused Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 80 adults with septic shock to see if raising blood pressure from 65 mmHg to 85 mmHg improves kidney function. Researchers used ultrasound to measure kidney blood flow and tracked changes in kidney injury stages. The goal was to find out if a higher blood pressure target helps protect the kidneys.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jun 2020

Finished

Feb 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patients (≥ 18 ans) * Admitted to the intensive care unit of Angers with * arterial hypotension requiring the etablishment of catecholamines * In a context of proven or suspected sepsis, whaterver the cause of this infection. * norepinephrine dose ⩾ 0.1µg/kg/min * After 2 hours of stabilization at 65 mmHg of mean arterial pressure Exclusion Criteria: * Pre-existing chronic renal failure (glomerular filtration rate \< 60 mL/min with MDRD) * Solitary kidney (anatomical or functional) * History of united or bilateral stenosis of the renal arteries * decision to stop or limit treatment * patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l and oliguria/anuria \> 72 h.) * pregnant, lactating or parturient woman * patient deprived of liberty by judicial or administrative decision * patient with psychiatric compulsory care * patient subject to legal protection measures

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Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Septic shock

Contacts and locations

Locations

  • CHU Angers. Médecine Intensive Réanimation et médecine hyperbare

    Angers, 49100, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.