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TB cases sought in COVID-19 trial volunteers

NCT ID NCT06585683

Knowledge-focused Sponsor: COVID-19 Prevention Network Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this group and improve future detection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify TB cases and biomarkers, pointing toward better TB detection methods.
What could go wrong
This is an observational substudy with no new treatment, so it won't directly improve health. Results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

5,694 people

The number who actually took part.

Started

Sep 2024

Finished

May 2025

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will involve approximately 6,000 volunteers who previously participated in the parent study, CoVPN 3008. Although volunteers may meet the inclusion/exclusion criteria, certain medical, psychiatric, occupational, or other conditions could complicate the evaluation of safety and/or immunogenicity, making some individuals unsuitable for enrollment or retention in the trial.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Enrollment into the CoVPN 3008 clinical trial. * Able and willing to complete the informed consent process: Volunteer demonstrates an understanding of this substudy. * Willingness to discuss TB status, undergo related testing/monitoring labs, and receive referrals for TB care. Exclusion Criteria: * Investigator's concern for difficulty with venous access based on clinical history and physical examination.

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Conditions

The condition(s) this trial relates to.

tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tuberculosis

Contacts and locations

Locations

  • Aurum Institute Klerksdorp CRS

    Klerksdorp, North West, South Africa

  • Baylor-Uganda CRS

    Kampala, Uganda

  • Blantyre CRS

    Blantyre, Malawi

  • CAPRISA eThekwini CRS

    Durban, KwaZulu-Natal, South Africa

  • Cfhrz Crs

    Lusaka, Zambia

  • Clinical HIV Research Unit (CHRU)/ Helen Joseph CRS

    Johannesburg, Gauteng, South Africa

  • Emavundleni CRS

    Cape Town, Western Cape, South Africa

  • Eswatini Prevention Center CRS

    Mbabane, Eswatini

  • FAM-CRU (Family Clinical Research Unit)

    Cape Town, Western Cape, South Africa

  • Gaborone CRS

    Gaborone, Botswana

  • Groote Schuur HIV CRS

    Cape Town, Western Cape, South Africa

  • Isipingo CRS

    Isipingo, KwaZulu-Natal, South Africa

  • Joint Clinical Research Centre

    Kampala, Uganda

  • Josha Resarch CRS

    Bloemfontein, Free State, South Africa

  • Kisumu Crs

    Kisumu, Kenya

  • Kliptown Soweto CRS

    Johannesburg, South Africa

  • Kombewa Clinical Research Center

    Kisumu, Kenya

  • MU-JHU Research Collaboration CRS

    Kampala, Uganda

  • Malawi CRS

    Lilongwe, Malawi

  • Masiphumelele Clinical Research Site (MASI) CRS

    Cape Town, Western Cape, South Africa

  • Matero Reference Clinic CRS

    Lusaka, Zambia

  • MeCRU CRS

    Ga-Rankuwa, Gauteng, South Africa

  • Moi University Clinical Research Centre

    Eldoret, Kenya

  • Nelson Mandela Academic Research Unit CRS

    Mthatha, Eastern Cape, South Africa

  • Newtown Clinical Research

    Johannesburg, Gauteng, South Africa

  • PHOENIX Pharma (Pty) Ltd

    Port Elizabeth, Eastern Cape, South Africa

  • PHRU Matlosana CRS

    Klerksdorp, South Africa

  • Qhakaza Mbokodo Research Clinic CRS

    Ladysmith, KwaZulu-Natal, South Africa

  • Rustenburg CRS

    Rustenburg, North West, South Africa

  • Soweto - Bara CRS

    Johannesburg, Gauteng, South Africa

  • Synergy Biomed Research Institute

    East London, Eastern Cape, South Africa

  • TASK Central

    Cape Town, Western Cape, South Africa

  • TASK Eden

    George, Western Cape, South Africa

  • Tembisa Clinic 4 CoVPN CRS

    Tembisa, Gauteng, South Africa

  • Tongaat CRS

    Durban, KwaZulu-Natal, South Africa

  • UNC Global Projects / Kamwala District Health Centre

    Lusaka, Zambia

  • UVRI-IAVI HIV Vaccine Program LTD. CRS

    Entebbe, Uganda

  • Univeristy of Cape Town Lung CRS Institute

    Cape Town, Western Cape, South Africa

  • Vulindlela CRS

    Durban, KwaZulu-Natal, South Africa

  • Wits RHI Ward 21 CRS

    Johannesburg, Gauteng, South Africa

  • Zambia Emory HIV Research Project - Ndola CoVPN CRS

    Ndola, Zambia

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