New vaccine aims to protect african children from deadly salmonella

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: All participants (adults, children, infants at 9 months of age and infants at 6 weeks of age) will be enrolled in the clinical site in Ghana and must satisfy ALL the following criteria at study entry: * Participants and/or participants' parent(s)/Legally Acceptable Representative(s) (LAR), who, in the opinion of the investigator, can and will comply with the requirements of the protocol (e.g., completion of the diary cards, return for follow-up visits). * Written or witnessed/thumb printed informed consent obtained from the participant/parent(s)/LAR(s) of the participant prior to performance of any study-specific procedure. * Healthy participants as established by medical history, clinical examination, and laboratory investigations. * Participants satisfying screening requirements. * Participants negative for human immunodeficiency virus (HIV), hepatitis B, and hepatitis C. Adult participants must satisfy ALL the following criteria in the study entry: * A male or female between and including 18 and 50 years of age at the time of the first study intervention administration. * Female participants of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause. * Female participants of childbearing potential may be enrolled in the study, if the participant: * has practiced adequate contraception for 1 month prior to the study intervention administration, and * has a negative pregnancy test on the day of study intervention administration, and * has agreed to continue adequate contraception during the entire treatment period and for 1 month after completion of the study intervention administration series. The Ghana card will be used as source document to verify the ages for the adults. Child participants must satisfy ALL the following criteria at study entry: * A male or female between and including 24 and 59 months of age at the time of the first study intervention administration. * Previously completed routine childhood vaccinations to the best knowledge of the participant's parent(s)/LAR's. * Born after a gestation period of ≥37 weeks. Infant participants must satisfy ALL the following criteria at study entry: * A male or female 6 weeks or 9 months of age at the time of the first study intervention administration. * Born after a gestation period of ≥37 weeks. * Born to a mother seronegative for HIV, hepatitis B virus and hepatitis C virus. The Road to Health Chart will be used as source document to confirm the ages for the children and infants. Exclusion criteria: Medical conditions * Known exposure to S. Typhimurium or S. Enteritidis during the period starting at birth for infants and children, and at 3 years for adults, as documented by patient records * History of any reaction or hypersensitivity likely to be exacerbated by any component of the study interventions. * Hypersensitivity, including allergy, to medicinal products or medical equipment whose use is foreseen in this study. * Progressive, unstable, or uncontrolled clinical conditions. * Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination * Major congenital defects, as assessed by the investigator. * Acute or chronic clinically significant pulmonary, cardiovascular, hepatic, or renal functional abnormality, as determined by physical examination or laboratory screening tests. * Acute disease and/or fever at the time of enrollment (fever is defined as temperature ≥ 38.0°C). * Recurrent history or uncontrolled neurological disorders or seizures. * Any clinically significant hematological and/or biochemical laboratory abnormality. * Undernutrition defined as World Health Organization (WHO) Z-score less than -2 standard deviation (SD). * Malaria infection defined as the presence of asexual parasites in the blood. * Clinical conditions representing a contraindication to intramuscular vaccination and blood draws. * Any behavioral or cognitive impairment or psychiatric disease that, in the opinion of the investigator, may interfere with the participant's ability to participate in the study. * Any other clinical condition that, in the opinion of the investigator, might pose additional risk to the participant due to participation in the study. Prior/Concomitant therapy * History of receiving any investigational iNTS or GMMA vaccines in the participant's life. * Use of any investigational or non-registered product other than the study interventions during the period beginning 30 days before the first dose of study interventions, or their planned use during the study period. * Planned administration/administration of a vaccine not foreseen by the study protocol in the period starting 14 days before each dose and ending 28 days after the last dose of study interventions administration, with the exception of flu vaccines and vaccines administered as part of a public health vaccination campaign. * A vaccine not foreseen by the study protocol administered during the period starting at 14 days before the first dose and ending 14 days after the last dose of study interventions administration for live vaccines or 7 days in case of inactivated vaccines\*, with the exception of flu vaccines or COVID-19 vaccine which may be considered on a case-by-case basis. * If emergency mass vaccination for an unforeseen public health threat (e.g., a pandemic) is organized by public health authorities outside the routine immunization program, the time period described above can be reduced if, provided it is used according to the local governmental recommendations and Sponsor is notified. Under such circumstances, a participant may be considered eligible for study enrollment and/or study intervention administration after the appropriate window for delay has passed and inclusion/exclusion criteria have been re-checked, and if the participant is confirmed to be eligible. * Administration of long-acting immune-modifying drugs at any time during the study period. * Administration of immunoglobulins and/or any blood products or plasma derivatives from birth (for infants 6 weeks of age) or during the period starting 3 months before the administration of the first dose of study intervention(s) or planned administration during the study period. * Chronic administration (defined as more than 14 days in total) of immunosuppressants or other immune-modifying drugs during the period starting 3 months prior to the first study intervention dose(s) up to the end of the study. For corticosteroids, this will mean prednisone equivalent \>=20 mg/day for adult participants/ \>=0.5 mg/kg/day with maximum of 20 mg/day for pediatric participants (infants and children). Inhaled and topical steroids are allowed. Prior/Concurrent clinical study experience • Concurrently participating in another clinical study, at any time during the study period, in which the participant has been or will be exposed to an investigational or a non-investigational intervention (vaccine, drug and device). Other exclusions * Pregnant or lactating female. * Female planning to become pregnant or planning to discontinue contraceptive precautions. * History of/current chronic alcohol consumption and/or drug abuse. This will be decided at the discretion of the investigator. * Any study personnel or their immediate dependents, family, or household members. * Child in care.