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New alert system aims to cut unnecessary antibiotics in pneumonia patients

NCT ID NCT05976581

Knowledge-focused Sponsor: Jonathan Baghdadi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly assigned to receive a recommendation to stop or reduce antibiotics or to usual care. The goal was to see if this approach could safely cut down on unnecessary antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electronic alert and structured communication
What this could lead to
If successful, this approach could help hospitals use antibiotics more wisely, reducing side effects and antibiotic resistance.
What could go wrong
This is a small, completed study with 107 participants, so results may not apply to all hospitals or patients. The intervention is behavioral, not a new drug, so impact may be limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

107 people

The number who actually took part.

Started

Nov 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients admitted to the University of Maryland Medical Center or University of Maryland Medical Center-Midtown Campus who are prescribed antibiotics for suspected community-acquired respiratory infection. * Protocol-based diagnostic testing supports possible viral infection, either by positive molecular test or low procalcitonin value. Exclusion Criteria: * Hospitalization for \>72 hours prior to protocol-based diagnostic testing. * Previous molecular testing for viral infection during the same hospital encounter. * Severely immunosuppressed, defined as having hematologic malignancy, solid organ tumor on chemotherapy, or solid organ transplant on immunosuppression

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Conditions

The condition(s) this trial relates to.

bacterial pneumonia pneumonia viral pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumonia Pneumonia - bacterial Pneumonia, viral

Contacts and locations

Locations

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of Maryland Medical Center - Midtown Campus

    Baltimore, Maryland, 21201, United States

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