Antibiotic showdown: which drug works best for staph blood infection?
NCT ID NCT03248063
First seen Jan 04, 2026 · Last updated Jun 19, 2026 · Updated 29 times
Summary
This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentially having fewer side effects and being easier to use. The main measure of success was a combination of survival, clearing the infection, and no relapse at 90 days.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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François-Xavier Lescure
Paris, 75018, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cloxacillin and cefazolin (antibiotics)
What this could lead to
If cefazolin works as well as cloxacillin, doctors may have a safer, more reliable option for treating this serious bloodstream infection.
What could go wrong
This is a completed trial, so results are available. However, the study is relatively small (315 participants) and open-label, which can introduce bias. The findings may not apply to all patient groups.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.