Hospital study tests decolonization to stop superbug infections
NCT ID NCT01209234
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a 5-day decolonization routine using nasal ointment, mouth rinse, and body wash could prevent MRSA infections in over 2,000 adults carrying the bacteria after hospital discharge. Participants were randomly assigned to either the decolonization regimen or standard education about MRSA. The goal was to see if the routine reduced infections and re-hospitalizations compared to education alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mupirocin and chlorhexidine
- What this could lead to
- If successful, this approach could become a standard way to prevent dangerous MRSA infections in people carrying the bacteria, reducing hospital readmissions.
- What could go wrong
- The trial is completed, but results may show only modest benefit or be limited to certain patient groups. Decolonization may not work for everyone and could cause skin irritation or allergies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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2,140 people
The number who actually took part.
- Start date
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Jan 2011
- Finished
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Jan 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 1\) At least 18 years old * 2\) Have had a positive culture (a type of test) for MRSA during recent hospital admission or within the 30 days prior to admission or following discharge * 3\) Able to give consent or have a primary caregiver provide consent * 4\) Able to bathe or shower or have this consistently performed by a willing caregiver Exclusion Criteria: * 1\) Known allergies to chlorhexidine or mupirocin
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chapman Care Center
Garden Grove, California, 92840, United States
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Country Villa Plaza
Santa Ana, California, 92707, United States
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Covington Care Center
Aliso Viejo, California, 92656, United States
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Downey Regional Medical Center
Downey, California, 90241, United States
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Fountain Valley Regional Hospital & Medical Center
Fountain Valley, California, 92708, United States
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Harbor-UCLA Medical Center
Torrence, California, 90502, United States
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Hoag Memorial Hospital Presbyterian
Newport Beach, California, 92658, United States
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Little Company of Mary - San Pedro
San Pedro, California, 90732, United States
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Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
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Mission Hospital
Mission Viejo, California, 92691, United States
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Orange Coast Memorial Medical Center
Fountain Valley, California, 92708, United States
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Pacific Haven HealthCare Center
Garden Grove, California, 92843, United States
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Providence Little Company of Mary Medical Center
Torrance, California, 90732, United States
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Regents Point at Windcrest
Irvine, California, 92612, United States
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Royale Healthcare
Santa Ana, California, 92707, United States
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Saddleback Memorial Medical Center - Laguna Hills
Laguna Hills, California, 92653, United States
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Saddleback Memorial Medical Center - San Clemente
San Clemente, California, 92673, United States
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St. Jude Medical Center
Fullerton, California, 92835, United States
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St. Mary Medical Center
Long Beach, California, 90813, United States
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Torrance Memorial Medical Center
Torrance, California, 90505, United States
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UC Irvine Medical Center
Orange, California, 92868, United States
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Ventura County Medical Center
Ventura, California, 93003, United States
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Villa Elena Health Care Center
Norwalk, California, 90650, United States
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West Anaheim Extended Care
Anaheim, California, 92804, United States
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