Tracking superbugs from mother to baby: a chicago study
NCT ID NCT06148480
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study looks at how drug-resistant bacteria, specifically ESBL-producing E. coli, are passed from mothers to their newborns during vaginal birth or scheduled C-sections. Researchers will test stool samples from 200 healthy mothers and their babies at a Chicago hospital to see how common these bacteria are and how often they are transmitted. By comparing the bacteria's genes, they hope to find what makes some strains better at spreading, which could lead to future ways to prevent infection.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could identify genetic targets to reduce the spread of drug-resistant bacteria from mother to baby.
- What could go wrong
- This is an observational study, not a treatment trial. It may not lead directly to new therapies, and findings may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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200 people
The number who actually took part.
- Started
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Jul 2020
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Mothers and their infants born vaginally or by scheduled c-section and who are admitted to Northwestern Medicine Prentice Women's Hospital
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women that are admitted to Northwestern Medicine Women's Hospital that have delivered an infant vaginally or have had a scheduled C-section without preceding labor. * Infants that are born vaginally who are healthy and do not require transfer to the NICU for any reason. Exclusion Criteria: * Temperature \>38 Celsius in labor * Caesarean section after labor * Rupture of membranes or done emergently * Antibiotic use in last trimester including for GBS+ * Delivery at \<35 weeks * Immunocompromised host including being HIV+ * Infant requiring transfer to NICU for any reason and infants who are transferred to the NICU.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Prentice Women's Hospital
Chicago, Illinois, 60611, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.