Colombian pneumonia study reveals key infection patterns

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * (1) Age ≥ 18 years old. * (2) Hospitalized at one of the hospitals of Sabana Centro Region, including both in-patient and observation status stay. * (3) Clinical signs and/or symptoms of an acute respiratory illness, as defined by ≥ 1 of the * following: * -New or worsening shortness of breath in the past 7 days * -New or worsening cough in the past 7 days * -New or worsening sputum production in the past 7 days * -New or worsening chest pain in the past 7 days * -Tachypnea to respiratory rate ≥ 22 breaths/min, not known to be chronic * -Hypoxia to SpO2 ≤ 92% not known to be chronic * -Initiation of invasive or non-invasive mechanical ventilation * (4) Clinical signs and/or symptoms of an acute infection, as defined by ≥ 1 of the following: * -Body temperature ≥ 38º C (100.4º F) or ≤ 35.5º C (95.9º F) * -Reported fever, chills, or feeling feverish at home without explicit documentation of a fever within the past 7 days * -White blood cell count \> 10.7 or \< 3.9 thousand cells/mcL-C-reactive protein \> 10 mg/L * -Altered mental status * (5) Radiologic evidence of pneumonia interpreted by a radiologist, defined as ≥ 1 of the following findings on chest x-ray (CXR), computed tomography (CT), or lung ultrasound completed within 48 hours before or after hospital admission: * -Pulmonary infiltrate not known to be chronic * -Pulmonary opacity is not known to be chronic (including ground-glass opacities on CT) * -Pulmonary consolidation is not known to be Exclusion Criteria: * (1) Enrollment in this study within the past 90 days. * (2) Development of pneumonia (as defined in the inclusion criteria) more than 48 hours after hospital admission (pneumonia developed 48 hours after admission will be considered hospital-acquired pneumonia). * (3) Inability to obtain consent from patient or surrogate for this study within 48 hours of hospital admission (including time at a transferring hospital before admission at a study hospital). * (4) Inability or unwillingness of the patient to provide any of the samples (Blood, Urine, and Sputum) within 48 hours of hospital admission (including time at a transferring hospital before admission at a study hospital). * (5) Non-pneumonia illness completely explains the patient's acute symptoms. Alternative non-pneumonia illnesses could include pulmonary embolism, acute heart failure, lung cancer, and pulmonary hemorrhage.