Could a simple skin test uncover silent TB?
NCT ID NCT07587164
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new skin test called C-TST to find latent (hidden) tuberculosis infections in 300 adults in Indonesia who were close contacts of TB patients. Participants received both the skin test and a standard blood test (IGRA) to see how well the new test worked. The goal was to see if C-TST could be a reliable and easier way to diagnose latent TB.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Recombinant Mycobacterium Tuberculosis Fusion Protein Tuberculin Skin Test (C-TST)
- What this could lead to
- If successful, this could provide a simpler, cheaper way to detect hidden TB infections, helping prevent the spread of TB.
- What could go wrong
- This is a completed study with 300 people in Indonesia, so results may not apply to other populations. The test may not be as accurate as existing methods.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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300 people
The number who actually took part.
- Started
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May 2025
- Finished
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Aug 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18 years - 65 years old 2. Being a close contact or household contact of a TB patient 3. Subject and/or legally acceptable representatives of the subject are willing to participate in the research by providing informed consent. 4. On the day of enrollment, the axillary body temperature was normal (\<37.3 °C) Exclusion Criteria: 1. Pregnant or lactating women 2. Individuals with active TB or those presenting symptoms suggestive of TB. 3. Patients with acute infectious diseases (such as measles, whooping cough, influenza, pneumonia, etc), acute conjunctivitis, acute otitis media, extensive skin diseases, and allergic constitution. 4. Have a history of TB disease 5. Received a TST within the last 6 months 6. Presence of skin conditions that might interfere with the interpretation after C-TST administration, such as tattoo and abnormal skin condition. 7. Currently participating in a clinical trial for medication. 8. Condition where researchers believe that there are any situations that may affect the evaluation of the trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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RSUP Persahabatan (Persahabatan General Hospital)
Jakarta, Jakarta Timur (East Jakarta), 13220, Indonesia
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Other studies related to the condition(s) this trial covers.